Opportunity Information: Apply for RFA HG 10 017
Apply for RFA HG 10 017
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical Sequencing Exploratory Research (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Jan 7, 2011 and posted on Dec 17, 2010.
- Applicants must submit their applications by Mar 3, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- Eligible applicants include: City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses Public housing authorities/Indian housing authorities State governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Native American tribal governments (Federally recognized) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Organizations).
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Opportunity Summary:
The Clinical Sequencing Exploratory Research (U01) funding opportunity (RFA-HG-10-017) was issued by the National Human Genome Research Institute (NHGRI) at the National Institutes of Health to support early, real-world studies of how genomic sequencing can be used in everyday clinical care. The main idea is to move beyond sequencing as a research-only activity and test what it looks like when broad genomic sequence information is generated, interpreted, and acted on in active health care settings where clinicians and patients are making real decisions. The opportunity is framed around the rapid growth in knowledge about human genetic variation, disease risk, and treatment response, paired with the major drop in cost and increase in speed of sequencing technologies that made clinical use increasingly plausible.
Projects under this announcement are expected to tackle practical, patient-centered questions across the full workflow of clinical sequencing. That includes how sequence data are produced in a clinically relevant way, how results are analyzed and interpreted so they are accurate and meaningful, and how those findings are translated into information a physician can use at the point of care. A major emphasis is also placed on communication: how results are conveyed to patients in a way that is understandable and useful, and how patients respond to receiving broad genomic information that may include unexpected findings or risk information that is not immediately actionable. The announcement explicitly calls for attention to ethical, legal, and psychosocial issues, recognizing that introducing large-scale genomic data into medical care raises questions about consent, privacy, potential anxiety or misunderstanding, family implications, and how to responsibly manage incidental or secondary findings.
The funding mechanism is a U01 cooperative agreement, which generally means NIH expects a more collaborative relationship than a standard grant, with substantial scientific or programmatic involvement from the agency during the project. The opportunity falls under the health category (CFDA 93.172, Human Genome Research) and does not require cost sharing or matching. NHGRI indicated an estimated total funding amount of $5.5 million, with an award ceiling of $1.5 million per award, signaling support for multiple exploratory projects rather than a single large effort, while still allowing for sizable, complex clinical studies.
Eligibility is broad and includes many types of U.S. organizations and governments, such as state, county, city or township governments; public and private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses. It also lists a wide range of other eligible applicants, including faith-based or community-based organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). This wide eligibility suggests NHGRI wanted proposals from diverse clinical environments and patient populations, not only traditional academic medical centers.
Key dates show the opportunity was posted on December 17, 2010, created January 7, 2011, and had an application deadline of March 3, 2011 (with the same original and current closing date). It was archived on April 3, 2011, meaning it is no longer open, but the content still reflects the federal priorities at the time: testing the clinical utility, interpretability, communication strategies, and broader impacts of using genomic sequencing in patient care. The full announcement was hosted on the NIH grants site at the provided link, and technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
What is the Clinical Sequencing Exploratory Research (U01) funding opportunity?
This opportunity (RFA-HG-10-017) was issued by the National Human Genome Research Institute (NHGRI) at the National Institutes of Health (NIH) to support early, real-world studies of how genomic sequencing could be used in everyday clinical care settings.
What is the main purpose of this funding announcement?
The purpose is to move beyond sequencing as a research-only activity and test what it looks like when broad genomic sequence information is generated, interpreted, and acted on in active health care environments where clinicians and patients are making real decisions.
Why was this opportunity important at the time it was issued?
The announcement was framed around rapid growth in knowledge about human genetic variation, disease risk, and treatment response, combined with major reductions in sequencing cost and increases in speed. Together, these changes made clinical use of sequencing increasingly plausible, and the opportunity aimed to explore how that could work in practice.
What types of questions were projects expected to address?
Projects were expected to tackle practical, patient-centered questions across the full workflow of clinical sequencing, including how clinically relevant sequence data are produced, how results are analyzed and interpreted for accuracy and meaning, and how findings are translated into information a physician can use at the point of care.
What parts of the clinical sequencing workflow were emphasized?
The opportunity emphasized end-to-end issues such as producing sequence data in a clinically relevant way, analyzing and interpreting results so they are accurate and meaningful, and integrating findings into care so clinicians can use them during real clinical decision-making.
What did the announcement say about communicating results to patients?
A major emphasis was placed on communication, including how to convey results to patients in ways that are understandable and useful, and how patients respond when they receive broad genomic information that may include unexpected findings or risk information that is not immediately actionable.
Did the opportunity address incidental or secondary findings?
Yes. The announcement highlighted that patients may receive unexpected findings or risk information that is not immediately actionable, and it emphasized understanding patient responses and responsible handling of such information in clinical settings.
What ethical, legal, and psychosocial issues were applicants expected to consider?
The announcement explicitly called for attention to ethical, legal, and psychosocial issues tied to introducing large-scale genomic data into medical care, including consent, privacy, potential anxiety or misunderstanding, family implications, and responsible management of incidental or secondary findings.
What funding mechanism was used for this opportunity?
The funding mechanism was a U01 cooperative agreement.
What does it mean that this is a U01 cooperative agreement?
A U01 cooperative agreement generally means NIH expects a more collaborative relationship than a standard grant, with substantial scientific or programmatic involvement from the agency during the project.
Which NIH institute issued this opportunity?
The opportunity was issued by NHGRI (National Human Genome Research Institute), part of NIH.
What is the program area or category associated with this opportunity?
The opportunity falls under the health category and is associated with CFDA 93.172, Human Genome Research.
How much funding was NHGRI expecting to provide in total?
NHGRI indicated an estimated total funding amount of $5.5 million for this opportunity.
What was the maximum award amount per project?
The award ceiling was $1.5 million per award.
Does the stated funding level suggest multiple awards?
Yes. An estimated total of $5.5 million with a $1.5 million ceiling per award signals support for multiple exploratory projects rather than a single large effort, while still allowing for sizable and complex clinical studies.
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
Who was eligible to apply?
Eligibility was broad and included many types of U.S. organizations and governments, such as state, county, city or township governments; public and private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses.
Were community-based and faith-based organizations eligible?
Yes. The eligibility list included faith-based or community-based organizations.
Were minority-serving institutions specifically included as eligible applicants?
Yes. The announcement listed Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions among eligible applicants.
Could U.S. territories or regional organizations apply?
Yes. Eligibility included regional organizations as well as U.S. territories or possessions.
Were foreign (non-U.S.) organizations eligible to apply?
Yes. The eligibility list included non-U.S. entities (foreign organizations).
What does the broad eligibility suggest about the types of projects NHGRI wanted?
The wide eligibility suggests NHGRI wanted proposals from diverse clinical environments and patient populations, not only traditional academic medical centers.
When was the opportunity posted and created?
The opportunity was posted on December 17, 2010, and created on January 7, 2011.
What was the application deadline?
The application deadline was March 3, 2011 (the original and current closing date were the same).
Is this funding opportunity still open?
No. It was archived on April 3, 2011, which means it is no longer open for applications.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants website at the provided link.
Who was identified as a contact for technical access issues?
Technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact.
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