Opportunity Information: Apply for RFA HG 12 016
Apply for RFA HG 12 016
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinically Relevant Genetic Variants Resource A Unified Approach for Identifying Genetic Variants for Clinical Use (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Jul 10, 2012 and posted on Jul 10, 2012.
- Applicants must submit their applications by Oct 23, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Private institutions of higher education Special district governments Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) State governments County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The funding opportunity titled "Clinically Relevant Genetic Variants Resource: A Unified Approach for Identifying Genetic Variants for Clinical Use (U01)" (Funding Opportunity Number RFA-HG-12-016) is a National Institutes of Health (NIH) cooperative agreement aimed at building a centralized, clinically oriented resource for genetic variants. The core goal is to create an organized and widely usable mechanism to identify which genetic variants matter for patient care and to disseminate consensus interpretations of those variants so they can be applied more consistently in clinical settings. In practical terms, the opportunity focuses on improving how genetic findings are translated into actionable information for clinicians, laboratories, and health systems by promoting agreement on variant relevance and interpretation.
This award uses a U01 cooperative agreement mechanism, meaning the project is expected to be carried out with substantial NIH involvement compared with a standard research grant. The activity category is health, and the FOA anticipates supporting a single award. The estimated total funding amount is $2,000,000, and there is no cost sharing or matching requirement. The opportunity was posted on July 10, 2012, with an application closing date of October 23, 2012, and it was archived on November 23, 2012. The associated CFDA number is 93.172 (Human Genome Research), reflecting its alignment with NIH efforts in genomics and the clinical application of genomic knowledge.
Eligibility for this FOA is broad across the public, private, and nonprofit sectors, reflecting the reality that clinically meaningful variant resources often require coordination across laboratories, data platforms, clinical organizations, and research groups. Eligible applicants include nonprofit organizations (both 501(c)(3) and those without 501(c)(3) status), public and private institutions of higher education, for-profit organizations (including small businesses, but excluding foreign institutions as primary applicants), and a wide range of governmental entities such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Tribal entities are also included, both federally recognized tribal governments and other tribal organizations. The FOA also explicitly recognizes eligibility for institutions and organizations serving specific communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, as well as regional organizations and U.S. territories or possessions. While non-U.S. (foreign) institutions are not eligible to apply as primary applicants, non-domestic components of U.S. organizations may participate, and foreign components as defined under NIH policy are allowed, which supports collaboration where specialized expertise or data may reside outside the United States.
Substantively, the FOA is centered on establishing a resource that does two connected things: identification and dissemination. "Identification" points to building a systematic approach for determining which variants are clinically relevant and should be prioritized for clinical use. "Dissemination of consensus information" indicates that the resource is meant not merely to store variant data, but to help converge on shared interpretations or agreed-upon characterizations of variants, then make those interpretations accessible to the broader community. This kind of resource helps reduce the fragmentation that can occur when different laboratories or clinical groups classify the same variant differently, and it supports more standardized decision-making when genetic information is used to guide diagnosis, risk assessment, or treatment.
The sponsoring agency is the NIH, specifically within the human genome research domain, and the full announcement is linked via the NIH grants site at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-12-016.html. For technical issues accessing the announcement or linking to the funding notice, the listed point of contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Clinically Relevant Genetic Variants Resource: A Unified Approach for Identifying Genetic Variants for Clinical Use (U01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-HG-12-016.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH), within the human genome research domain.
What type of award mechanism is being used?
This opportunity uses a U01 cooperative agreement mechanism.
What does a U01 cooperative agreement mean for NIH involvement?
A U01 cooperative agreement indicates the project is expected to be carried out with substantial NIH involvement compared with a standard research grant.
What is the main goal of this FOA?
The core goal is to build a centralized, clinically oriented resource for genetic variants that helps identify which variants matter for patient care and disseminates consensus interpretations so they can be applied more consistently in clinical settings.
What does the resource aim to improve in practice?
It focuses on improving how genetic findings are translated into actionable information for clinicians, laboratories, and health systems by promoting agreement on variant relevance and interpretation.
What are the two connected functions emphasized in the FOA?
The FOA centers on (1) identification of clinically relevant variants through a systematic approach and (2) dissemination of consensus information about those variants to the broader community.
What does "identification" refer to in this opportunity?
"Identification" refers to building a systematic approach for determining which variants are clinically relevant and should be prioritized for clinical use.
What does "dissemination of consensus information" mean in this context?
It means the resource is intended not only to store variant data, but also to help converge on shared interpretations or agreed-upon characterizations of variants and make those interpretations accessible for wider use.
Why is consensus interpretation of variants important?
Consensus interpretation helps reduce fragmentation when different laboratories or clinical groups classify the same variant differently, supporting more standardized decision-making when genetic information is used for diagnosis, risk assessment, or treatment.
What is the activity category for this funding opportunity?
The activity category is health.
How many awards does the FOA anticipate supporting?
The FOA anticipates supporting a single award.
What is the estimated total funding amount?
The estimated total funding amount is $2,000,000.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement.
When was the opportunity posted?
The opportunity was posted on July 10, 2012.
What is the application closing date?
The application closing date was October 23, 2012.
When was the opportunity archived?
The opportunity was archived on November 23, 2012.
What is the CFDA number associated with this FOA?
The associated CFDA number is 93.172 (Human Genome Research).
What kinds of organizations are eligible to apply?
Eligibility is broad across public, private, and nonprofit sectors. Eligible applicants include nonprofit organizations (501(c)(3) and those without 501(c)(3) status), public and private institutions of higher education, for-profit organizations (including small businesses, but excluding foreign institutions as primary applicants), and many types of governmental entities and tribal entities.
Are nonprofit organizations eligible?
Yes. Both 501(c)(3) nonprofits and nonprofits without 501(c)(3) status are eligible.
Are colleges and universities eligible?
Yes. Public and private institutions of higher education are eligible.
Are for-profit organizations eligible?
Yes. For-profit organizations, including small businesses, are eligible (with the exception that foreign institutions are excluded as primary applicants).
Which governmental entities are eligible?
Eligible governmental entities include state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal entities eligible?
Yes. Federally recognized tribal governments and other tribal organizations are included in the eligibility list.
Are U.S. territories and possessions eligible?
Yes. Regional organizations and U.S. territories or possessions are explicitly recognized as eligible.
Are community-based and faith-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly recognized as eligible.
Are institutions serving specific communities explicitly recognized as eligible?
Yes. The FOA explicitly recognizes eligibility for organizations including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.
Are foreign (non-U.S.) institutions eligible to apply as the primary applicant?
No. Non-U.S. (foreign) institutions are not eligible to apply as primary applicants.
Can foreign or non-U.S. components participate in the project in any way?
Yes. Non-domestic components of U.S. organizations may participate, and foreign components (as defined under NIH policy) are allowed, supporting collaboration where expertise or data may be outside the United States.
Where can applicants find the full announcement?
The full announcement is available on the NIH grants site at http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-12-016.html.
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement or linking to the funding notice, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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