Opportunity Information: Apply for PAR 10 099

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Collaborative Clinical Trials in Drug Abuse (Collaborative R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
  • This funding opportunity was created on Mar 8, 2010 and posted on Mar 8, 2010.
  • Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Special district governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The grant opportunity titled "Collaborative Clinical Trials in Drug Abuse (Collaborative R01)" (Funding Opportunity Number PAR 10-099) is a National Institutes of Health program administered through the National Institute on Drug Abuse (NIDA). Its central goal is to push clinical drug abuse research beyond what a single research site or one investigative team can realistically accomplish on its own. The emphasis is on building genuine, multi-site collaboration among different clinical research groups so investigators can jointly run clinical trials that need larger pools of participants, broader recruitment reach, or more diverse settings than any one location could feasibly provide.

At the core of this opportunity is the idea that certain questions in drug abuse and addiction research cannot be answered well without scale. Some outcome measures are uncommon, require long follow-up, or show meaningful effects only when sample sizes are large. Likewise, some patient populations can be difficult to recruit in sufficient numbers at a single institution, such as specialized subgroups, co-morbid populations, or participants meeting narrower eligibility criteria. This funding announcement is designed to make those kinds of studies more practical by encouraging trials that are planned from the start as collaborative efforts across multiple clinical sites or research networks.

The mechanism of support is the NIH Research Project Grant (R01), which generally supports discrete, specified projects led by investigators proposing a defined research plan. In this context, the R01 mechanism is used to fund collaborative clinical trials focused on drug abuse and addiction, with the expectation that investigators will coordinate protocol design, recruitment, data collection, and outcome evaluation across participating groups. While the announcement does not spell out a fixed budget amount or a guaranteed number of awards, it makes clear that awards depend on two things: the availability of federal funds and the submission of enough high-quality, competitive applications. In other words, funding is not automatic; proposals must be strong and the institute must have money available in the relevant funding year.

This is a discretionary grant program in the education and health activity area, tied to CFDA number 93.279 (Drug Abuse and Addiction Research Programs). There is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of receiving the award. The opportunity was posted on March 8, 2010, with an original and final closing date listed as May 7, 2013, and an archive date of June 7, 2013, indicating the announcement is no longer open for new submissions under that specific solicitation.

Eligibility is broad and includes many types of organizations that commonly participate in NIH research, spanning public and private higher education institutions, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a wide range of government bodies such as state, county, city/township governments, special district governments, and independent school districts. It also explicitly includes Native American tribal governments (federally recognized) and other tribal organizations, public housing authorities/Indian housing authorities, and additional categories such as faith-based or community-based organizations, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, U.S. territories or possessions, regional organizations, and even non-U.S. entities (foreign organizations). Federal agencies are also listed among eligible applicants. The broad eligibility reflects the reality that effective multi-site clinical trial collaboration can involve academic medical centers, community clinics, tribal health organizations, public health systems, and other research-capable partners.

For those needing the full original announcement text and official application instructions, the source points to the NIH Grants Guide page for PAR 10-099 at http://grants.nih.gov/grants/guide/pa-files/PAR-10-099.html. Administrative support contacts are provided through the NIH Office of Extramural Research (OER) webmaster for access or linking issues, indicating that applicants were expected to rely on the electronic announcement for complete requirements, submission procedures, and any institute-specific expectations around trial design, collaboration structure, and review criteria.

Frequently Asked Questions (FAQs)

What is the title and funding opportunity number for this grant?

The opportunity is titled "Collaborative Clinical Trials in Drug Abuse (Collaborative R01)" and the Funding Opportunity Number is PAR 10-099.

Which federal agency and NIH institute administer this opportunity?

This is a National Institutes of Health (NIH) program administered through the National Institute on Drug Abuse (NIDA).

What is the main purpose of this funding opportunity?

The central goal is to enable clinical drug abuse and addiction research that goes beyond what a single research site or one investigative team can accomplish alone, by supporting genuine multi-site collaboration to run clinical trials that require larger participant pools, broader recruitment reach, or more diverse settings.

What kinds of studies is this opportunity designed to support?

It is designed to support collaborative, multi-site clinical trials in drug abuse and addiction research, especially those that need scale to answer research questions effectively (for example, trials requiring large sample sizes, long follow-up, uncommon outcome measures, or recruitment of hard-to-enroll populations).

Why does this opportunity emphasize multi-site collaboration?

Some scientific questions in drug abuse and addiction cannot be answered well without scale. Multi-site collaboration can make it practical to recruit enough participants, reach specialized subgroups, include co-morbid populations, operate across varied clinical settings, and evaluate outcomes that are uncommon or that require extended follow-up.

What grant mechanism is used for this opportunity?

The mechanism of support is the NIH Research Project Grant (R01). In this program, the R01 supports discrete, specified projects where investigators propose a defined research plan for collaborative clinical trials conducted across multiple sites or research groups.

What does the R01 mechanism imply about the project structure?

Based on the description provided, the expectation is that investigators will propose a defined clinical trial research plan and coordinate core trial activities across participating groups, including protocol design, recruitment, data collection, and outcome evaluation.

Does the announcement specify a fixed budget amount or number of awards?

No. The information provided states that the announcement does not spell out a fixed budget amount or a guaranteed number of awards.

What determines whether awards are made under this opportunity?

Awards depend on the availability of federal funds and the submission of enough high-quality, competitive applications. Funding is not automatic.

What is the activity area or program type associated with this opportunity?

It is described as a discretionary grant program in the education and health activity area.

What is the CFDA number associated with this grant program?

The CFDA number listed is 93.279, labeled "Drug Abuse and Addiction Research Programs."

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of receiving an award.

When was this opportunity posted, and what were the closing and archive dates?

It was posted on March 8, 2010. The original and final closing date listed is May 7, 2013, and the archive date is June 7, 2013.

Is this funding opportunity still open to new submissions?

No. Because the final closing date was May 7, 2013 and the opportunity was archived on June 7, 2013, the announcement is no longer open for new submissions under that specific solicitation.

Who is eligible to apply?

Eligibility is broad and includes many organization types commonly involved in NIH research, including public and private higher education institutions, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a wide range of government bodies.

Are state and local government entities eligible?

Yes. The eligible categories listed include state governments, county governments, city or township governments, special district governments, and independent school districts.

Are tribal entities eligible?

Yes. The eligibility list explicitly includes Native American tribal governments (federally recognized) and other tribal organizations.

Are public housing authorities eligible?

Yes. Public housing authorities and Indian housing authorities are included among eligible applicants.

Are faith-based or community-based organizations eligible?

Yes. The eligibility categories explicitly include faith-based and community-based organizations.

Are minority-serving institutions eligible?

Yes. The eligibility list includes Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions.

Are U.S. territories or regional organizations eligible?

Yes. The eligibility list includes U.S. territories or possessions and regional organizations.

Are non-U.S. (foreign) organizations eligible to apply?

Yes. The eligibility list explicitly includes non-U.S. entities (foreign organizations).

Are federal agencies eligible to apply?

Yes. Federal agencies are listed among eligible applicants.

What types of collaborations does this opportunity aim to encourage?

It aims to encourage genuine multi-site collaboration among different clinical research groups, where investigators jointly plan and run clinical trials that benefit from combined recruitment capacity, broader geographic reach, or diverse clinical settings.

What kinds of participant recruitment challenges is this grant meant to address?

It is meant to address trials where recruitment is difficult at a single institution, including specialized subgroups, participants with co-morbid conditions, or studies with narrow eligibility criteria that limit the number of qualifying participants at any one site.

Where can applicants find the full original announcement and official instructions?

The source provided points to the NIH Grants Guide page for PAR 10-099 at http://grants.nih.gov/grants/guide/pa-files/PAR-10-099.html.

Who is listed as a contact for administrative support related to access or linking issues?

Administrative support contacts are provided through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.

What does the announcement suggest about where the complete requirements and review expectations are documented?

It indicates that applicants were expected to rely on the electronic announcement for complete requirements, submission procedures, and any institute-specific expectations related to trial design, collaboration structure, and review criteria.

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