Opportunity Information: Apply for RFA MH 12 110

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Collaborative Hubs for International Research on Mental Health (U19)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
  • This funding opportunity was created on Sep 27, 2011 and posted on Sep 27, 2011.
  • Applicants must submit their applications by Jan 11, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $500,000.00 in funding.
  • Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Small businesses Independent school districts County governments Private institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Collaborative Hubs for International Research on Mental Health (U19) funding opportunity (RFA-MH-12-110) was issued by the National Institute of Mental Health (NIMH), part of the National Institutes of Health, to expand practical, real-world evidence on mental health interventions in low- and middle-income countries (LMICs) as defined by the World Bank. The main idea is to fund a set of regional research hubs that do more than run isolated studies; they are meant to function as long-term platforms that both generate rigorous intervention evidence and strengthen local research capacity. The goal is explicitly tied to improving mental health outcomes across populations, including men, women, and children, and to building a stronger base of knowledge about what works, for whom, and in which settings.

The program uses a cooperative agreement mechanism (U19), which typically means the projects are expected to involve substantial scientific or programmatic involvement from NIMH staff compared with a standard research grant. In practice, this mechanism is often chosen when an agency wants investigators to operate as part of a coordinated initiative, follow shared expectations, and collaborate across sites, rather than working entirely independently. Here, the hubs are designed to function collectively as a network, allowing the group to answer research questions within individual regions and also to tackle cross-regional questions where comparisons, harmonized methods, or pooled learning could lead to stronger and more generalizable conclusions.

Each funded hub is intended to be regionally focused, with one hub aligned to one of six broad geographic regions: East Asia and the Pacific; Europe and Central Asia; Latin America and the Caribbean; Middle East and North Africa; South Asia; and Sub-Saharan Africa. The emphasis on regional structure signals that NIMH wanted each award to be grounded in local contexts, health systems, cultures, and implementation realities, rather than assuming a one-size-fits-all approach. Alongside conducting research, every hub is expected to provide capacity-building opportunities, meaning they should help develop and sustain local expertise, infrastructure, and training pathways that enable LMIC researchers and institutions to lead future mental health intervention research.

From an administrative standpoint, this was a discretionary health funding opportunity under CFDA 93.242 (Mental Health Research Grants). It did not require cost sharing or matching, which lowers a common barrier for applicants, especially those working in resource-constrained environments. The estimated total funding listed for the opportunity was $1,000,000, with an award ceiling of $500,000, indicating an intent to support multiple hubs while placing a cap on the maximum budget per award under the announcement’s terms.

Eligibility was broad and included many U.S.-based organization types such as public and private institutions of higher education, state and local governments, nonprofit organizations (including those with and without 501(c)(3) status, with some distinctions), small businesses, and other for-profit entities. Importantly for an international mental health initiative, non-U.S. entities (foreign institutions) were explicitly eligible to apply, and foreign components of U.S. organizations were allowed as defined in NIH policy. The eligibility language also highlights inclusion of a wide range of institutions and community-linked entities, such as faith-based and community-based organizations, regional organizations, and several categories of minority-serving institutions (for example, HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian-serving institutions). This breadth aligns with the FOA’s capacity-building and partnership-oriented goals, where success often depends on strong local collaboration and diverse institutional participation.

Key dates show this was posted on September 27, 2011, with an original and current closing date of January 11, 2012, and an archive date of February 11, 2012, meaning the competition is historical rather than currently open. The full announcement was hosted through the NIH grants guide, with standard NIH Office of Extramural Research (OER) contact points provided for technical access issues.

Frequently Asked Questions (FAQs)

What is the name of this funding opportunity?

The opportunity is titled Collaborative Hubs for International Research on Mental Health (U19), under FOA number RFA-MH-12-110.

Which agency issued this FOA?

This FOA was issued by the National Institute of Mental Health (NIMH), which is part of the National Institutes of Health (NIH).

What is the main purpose of the program?

The program is designed to expand practical, real-world evidence on mental health interventions in low- and middle-income countries (LMICs) (as defined by the World Bank). It aims to fund regional research hubs that function as long-term platforms to both (1) generate rigorous evidence on interventions and (2) strengthen local research capacity.

What populations is the program intended to benefit?

The goal is tied to improving mental health outcomes across populations, explicitly including men, women, and children.

What does "LMIC" mean in this FOA?

LMIC refers to low- and middle-income countries as defined by the World Bank.

What kind of award mechanism is used (U19), and what does it imply?

The FOA uses a cooperative agreement mechanism (U19). This typically implies substantial scientific or programmatic involvement from NIMH staff compared with a standard research grant, and an expectation that investigators operate as part of a coordinated initiative with shared expectations and collaboration across sites.

Are the hubs expected to collaborate with each other?

Yes. The hubs are designed to function collectively as a network, supporting research within regions and also enabling cross-regional questions through comparisons, harmonized methods, and pooled learning to strengthen and generalize findings.

Is the program focused on individual studies or something broader?

It is explicitly broader than isolated studies. The hubs are meant to serve as long-term platforms that produce intervention evidence and build sustainable capacity for ongoing mental health research in LMIC settings.

How are the hubs organized geographically?

Each funded hub is intended to be regionally focused, with one hub aligned to one of six broad regions:

  • East Asia and the Pacific
  • Europe and Central Asia
  • Latin America and the Caribbean
  • Middle East and North Africa
  • South Asia
  • Sub-Saharan Africa

Why does the FOA emphasize a regional structure?

The regional structure signals a focus on grounding research in local contexts, including health systems, cultures, and implementation realities, rather than assuming a one-size-fits-all approach.

What is meant by "capacity building" in this opportunity?

Each hub is expected to provide capacity-building opportunities that develop and sustain local expertise, infrastructure, and training pathways so that LMIC researchers and institutions can lead future mental health intervention research.

What CFDA program is associated with this funding opportunity?

This opportunity is listed under CFDA 93.242, described as Mental Health Research Grants.

Is cost sharing or matching required?

No. The FOA states that cost sharing/matching is not required.

How much total funding was estimated for the opportunity?

The estimated total funding listed is $1,000,000.

What is the maximum award amount (award ceiling)?

The award ceiling listed is $500,000, indicating a cap on the maximum budget per award under the terms of this announcement.

Does the funding level suggest multiple awards?

Based on the stated $1,000,000 estimated total funding and a $500,000 ceiling per award, the announcement appears structured to support multiple hubs rather than a single award.

Who is eligible to apply?

Eligibility is broad and includes many organization types, such as:

  • Public and private institutions of higher education
  • State and local governments
  • Nonprofit organizations (including those with and without 501(c)(3) status, with distinctions noted)
  • Small businesses
  • Other for-profit entities
  • Faith-based organizations
  • Community-based organizations
  • Regional organizations
  • Minority-serving institutions (including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian-serving institutions)

Are non-U.S. (foreign) institutions eligible to apply?

Yes. Non-U.S. entities (foreign institutions) were explicitly eligible to apply.

Are foreign components of U.S. organizations allowed?

Yes. The FOA allows foreign components of U.S. organizations as defined in NIH policy.

When was this opportunity posted?

The FOA was posted on September 27, 2011.

What was the application deadline?

The original and current closing date listed is January 11, 2012.

Is this FOA currently open?

No. It is a historical opportunity. The FOA lists an archive date of February 11, 2012, indicating the competition is no longer active.

Where was the full announcement published?

The full announcement was hosted through the NIH grants guide.

Who should applicants contact for technical access issues?

The announcement references standard NIH Office of Extramural Research (OER) contact points for technical access issues.

What makes this program different from a typical independent research grant?

Two features stand out in the FOA description: (1) the use of a U19 cooperative agreement with substantial NIMH involvement, and (2) an expectation that funded hubs work as part of a coordinated network to address both regional and cross-regional research questions while building long-term capacity.

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