Opportunity Information: Apply for RFA HD 08 025

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Collaborative Pediatric Critical Care Research Network (U10)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Dec 10, 2008 and posted on Aug 22, 2008.
  • Applicants must submit their applications by Mar 31, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
  • Eligible applicants include: Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments State governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:

The Collaborative Pediatric Critical Care Research Network (CPCCRN) (U10) funding opportunity (RFA-HD-08-025) is a National Institutes of Health (NIH) program issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to support a coordinated, multi-center clinical research network focused on critically ill children. The main goal is to bring together experienced pediatric critical care sites to run rigorous, network-based studies that evaluate the safety and effectiveness of treatment and management strategies used in pediatric intensive care. In parallel, the network is meant to advance understanding of the underlying biology and disease mechanisms (pathophysiology) that drive critical illness and injury in childhood, so that care can be improved with stronger evidence and better-targeted interventions.

This program uses the U10 cooperative agreement mechanism, which is designed for large, complex research efforts where the NIH expects to have substantial scientific and programmatic involvement during the award. In practical terms, that means funded sites are not just receiving support for independent projects; they are joining an organized network and working collaboratively with NICHD and other participating centers to plan, implement, and conduct multi-site clinical studies. The network structure is intended to make it easier to enroll sufficient numbers of patients, standardize protocols across hospitals, share data, and produce findings that can be translated into practice more quickly than single-site efforts.

NICHD planned to commit approximately $2.5 million in total costs (including both direct costs and facilities and administrative costs) in fiscal year 2009 to support CPCCRN clinical sites. The agency anticipated making about 6 to 8 awards, covering a mix of new sites and/or competing continuation awards for ongoing participation. Because the focus is on clinical sites within a network, applicants are generally expected to demonstrate the capacity to recruit and manage pediatric critical care populations, implement protocol-driven studies, adhere to common data and safety requirements, and collaborate effectively across institutions as part of a standing research infrastructure.

The opportunity was categorized as a discretionary grant program and listed under CFDA 93.865 (Child Health and Human Development Extramural Research). There was no cost-sharing or matching requirement. The funding announcement was posted on August 22, 2008, with an original and current closing date of March 31, 2009, and an archive date of May 1, 2009.

Eligibility was broad and included many organization types that could potentially house a capable pediatric critical care research site. Eligible applicants included public and private institutions of higher education, state and local governmental entities (such as state governments, county governments, and city or township governments), special district governments, and a range of nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits, other than institutions of higher education). The announcement also explicitly included eligibility for organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, as well as eligible federal agencies. This broad eligibility reflects the reality that pediatric critical care research programs can be embedded in different institutional and governance settings, as long as the applicant can credibly fulfill the responsibilities of a high-performing network clinical site.

For applicants and institutions that needed to review full details, NICHD provided an official NIH Grants Guide link to the complete announcement (http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-08-025.html). For access or technical issues with the posting, the contact point listed was the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).

Frequently Asked Questions (FAQs): Collaborative Pediatric Critical Care Research Network (CPCCRN) (U10) - RFA-HD-08-025

What is the CPCCRN (U10) funding opportunity?

The Collaborative Pediatric Critical Care Research Network (CPCCRN) (U10) funding opportunity (RFA-HD-08-025) is a National Institutes of Health (NIH) program issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to support a coordinated, multi-center clinical research network focused on critically ill children.

What is the primary goal of CPCCRN?

The main goal is to bring together experienced pediatric critical care sites to run rigorous, network-based studies that evaluate the safety and effectiveness of treatment and management strategies used in pediatric intensive care.

Does CPCCRN also support research on disease mechanisms?

Yes. In parallel with evaluating treatments and management strategies, the network is intended to advance understanding of the underlying biology and disease mechanisms (pathophysiology) that drive critical illness and injury in childhood, with the aim of improving care through stronger evidence and better-targeted interventions.

Which NIH institute issues and manages this opportunity?

This opportunity is issued by NICHD (the Eunice Kennedy Shriver National Institute of Child Health and Human Development), a component of NIH.

What funding mechanism is used (U10), and what does it mean?

The program uses the U10 cooperative agreement mechanism. This mechanism is intended for large, complex research efforts where NIH expects to have substantial scientific and programmatic involvement during the award.

How is a cooperative agreement different from a typical grant for this program?

Under the U10 cooperative agreement, funded sites are not simply supported to run independent projects. Instead, they join an organized network and work collaboratively with NICHD and other participating centers to plan, implement, and conduct multi-site clinical studies, with substantial NIH involvement.

What kinds of activities are CPCCRN clinical sites expected to perform?

Clinical sites are expected to participate in network-based, multi-site clinical research. The network structure is designed to support enrolling sufficient numbers of patients, standardizing protocols across hospitals, sharing data, and producing findings that can be translated into practice more quickly than single-site efforts.

What capabilities are applicants generally expected to demonstrate?

Applicants are generally expected to demonstrate the capacity to recruit and manage pediatric critical care populations, implement protocol-driven studies, adhere to common data and safety requirements, and collaborate effectively across institutions as part of a standing research infrastructure.

How much funding did NICHD plan to commit for CPCCRN clinical sites?

NICHD planned to commit approximately $2.5 million in total costs in fiscal year 2009 to support CPCCRN clinical sites. Total costs include both direct costs and facilities and administrative (F&A) costs.

How many awards were anticipated?

NICHD anticipated making about 6 to 8 awards.

Were awards limited to new applicants, or could existing sites continue?

The anticipated awards were expected to cover a mix of new sites and/or competing continuation awards for ongoing participation.

Is cost sharing or matching required?

No. The announcement states there was no cost-sharing or matching requirement.

What is the CFDA number associated with this opportunity?

The opportunity was listed under CFDA 93.865, titled Child Health and Human Development Extramural Research.

How was the program categorized?

The opportunity was categorized as a discretionary grant program.

Who is eligible to apply?

Eligibility was broad and included many organization types that could potentially house a capable pediatric critical care research site, as long as the applicant could credibly fulfill the responsibilities of a high-performing network clinical site.

Are colleges and universities eligible?

Yes. Eligible applicants included public and private institutions of higher education.

Are state and local government entities eligible?

Yes. Eligibility included state and local governmental entities such as state governments, county governments, and city or township governments, as well as special district governments.

Are nonprofit organizations eligible?

Yes. Eligibility included a range of nonprofit organizations, including both 501(c)(3) and certain non-501(c)(3) nonprofits (other than institutions of higher education).

Are certain institution types explicitly included (HBCUs, HSIs, tribal institutions, etc.)?

Yes. The announcement explicitly included Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and also included faith-based or community-based organizations.

Are federal agencies eligible to apply?

Yes. The announcement indicated that eligible federal agencies were included among eligible applicants.

What is the funding opportunity number (RFA)?

The funding opportunity is identified as RFA-HD-08-025.

When was the funding announcement posted?

The funding announcement was posted on August 22, 2008.

What was the closing date for applications?

The original and current closing date listed was March 31, 2009.

When was the opportunity archived?

The archive date listed was May 1, 2009.

Where can applicants find the complete official announcement?

NICHD provided the official NIH Grants Guide link to the complete announcement at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HD-08-025.html.

Who should be contacted for access or technical issues with the posting?

For access or technical issues with the posting, the contact point listed was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

What is the purpose of using a network structure for this research?

The network structure is intended to make it easier to enroll sufficient numbers of patients, standardize protocols across hospitals, share data, and produce findings that can be translated into practice more quickly than single-site efforts.

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