Opportunity Information: Apply for RFA HL 16 003
Apply for RFA HL 16 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Collaborative Projects to Accelerate Research in Organ Fibrosis (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Jul 17, 2015 and posted on Jul 17, 2015.
- Applicants must submit their applications by Oct 21, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: County governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Independent school districts Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Collaborative Projects to Accelerate Research in Organ Fibrosis (R01) (Funding Opportunity Number RFA-HL-16-003) is a discretionary National Institutes of Health (NIH) grant opportunity designed to speed progress in understanding and treating organ fibrosis by pushing researchers to work across traditional organ-specific boundaries. The scientific premise behind the program is that fibrogenesis is a normal and necessary part of wound healing, but when the process becomes dysregulated, persistent, or self-sustaining, it can drive progressive scarring in vital organs. That scarring can ultimately impair function and lead to serious symptoms and organ failure. The FOA emphasizes that, at the cellular and molecular levels, many features of abnormal fibrogenesis look strikingly similar across organ systems, which creates a strong rationale for comparative, collaborative studies rather than isolated efforts focused on a single tissue.
The FOA particularly encourages collaboration among investigators who study fibrosis in different organs such as the heart, lung, kidney, and bone marrow. It also highlights real-world clinical and exposure scenarios where multi-organ fibrosis can occur, such as systemic sclerosis or injury from ionizing radiation. In those settings, understanding shared pathways and organ-specific differences could help explain why fibrosis spreads, why it progresses differently by tissue, and how therapies might be designed to work broadly or be tailored to a specific organ environment. The underlying message is that coordinated, cross-disciplinary projects are likely to identify common mechanisms, discover transferable therapeutic targets, and reduce duplication of effort across fields.
Applications are expected to use the NIH Research Project Grant (R01) mechanism and should be organized around collaborative projects that do one or more of the following: (1) characterize and compare mechanisms that drive aberrant fibrogenesis across different organ systems, (2) study and compare mechanisms of fibrosis resolution, including pathways that stop, reverse, or remodel fibrotic tissue, (3) develop novel therapeutic strategies aimed at preventing, reducing, or resolving organ fibrosis, and/or (4) create new technologies that enable better fibrosis research, such as tools to measure fibrotic burden, track relevant cell populations, profile extracellular matrix remodeling, or model disease processes in ways that are more predictive. The emphasis on both disease-driving mechanisms and resolution reflects a dual interest in understanding how fibrosis starts and persists, as well as how it might be actively reversed or repaired.
From an administrative standpoint, the program is categorized under Health and is associated with multiple NIH CFDA numbers that align with cardiovascular, lung, and blood-related research portfolios (93.837, 93.838, and 93.839). The opportunity does not require cost sharing or matching, which generally lowers barriers for applicants who might not have institutional funds to commit. The listed award ceiling is $350,000, indicating an upper limit on the amount expected per award under the terms described in the source information.
Eligibility is broad and includes many U.S.-based organization types commonly eligible for NIH grants. This includes public and private institutions of higher education, nonprofits (including those with 501(c)(3) status and certain nonprofits without 501(c)(3) status), small businesses, and other for-profit entities (with distinctions between small businesses and other for-profits), as well as state, county, city/township, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments or tribal organizations. The FOA explicitly notes additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Tribal Colleges and Universities (TCCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations and eligible federal agencies. At the same time, it makes clear that non-U.S. (foreign) institutions and non-U.S. components of U.S. organizations are not eligible to apply, although foreign components as defined in the NIH Grants Policy Statement are allowed, which can permit specific international collaborations under NIH rules while keeping the applicant organization domestic.
Key timeline details in the source record show the opportunity was posted and created on July 17, 2015, with an original and current closing date of October 21, 2016, and an archive date of November 21, 2016. In other words, it is an archived FOA rather than an open, active solicitation, but it remains useful as a reference point for how NIH has framed collaborative, multi-organ fibrosis research initiatives and what kinds of projects and partnerships it sought to stimulate.
The full announcement is referenced at http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-16-003.html, and the contact point for access or technical issues is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the funding opportunity called and what is the number?
The opportunity is titled "Collaborative Projects to Accelerate Research in Organ Fibrosis (R01)" and the Funding Opportunity Number is RFA-HL-16-003.
Which agency is offering this grant opportunity?
This is a discretionary grant opportunity from the National Institutes of Health (NIH).
What is the main purpose of this FOA?
The FOA is designed to speed progress in understanding and treating organ fibrosis by encouraging researchers to work across traditional, organ-specific boundaries and to pursue comparative, collaborative studies spanning multiple organ systems.
Why does the FOA emphasize cross-organ collaboration?
The FOA explains that many cellular and molecular features of abnormal fibrogenesis are strikingly similar across organ systems. Because of these similarities, coordinated studies across different tissues may identify common mechanisms, uncover transferable therapeutic targets, and reduce duplication of effort compared to isolated, single-organ efforts.
What is the scientific premise behind the program?
The program is built on the premise that fibrogenesis is normally part of wound healing, but when it becomes dysregulated, persistent, or self-sustaining, it can cause progressive scarring in vital organs. That scarring can impair function and ultimately contribute to serious symptoms and organ failure.
Which organs are specifically mentioned as areas for collaboration?
The FOA particularly encourages collaboration among investigators studying fibrosis in different organs, including the heart, lung, kidney, and bone marrow.
Does the FOA address multi-organ fibrosis scenarios in the real world?
Yes. The FOA highlights clinical and exposure scenarios in which multi-organ fibrosis can occur, including systemic sclerosis and injury from ionizing radiation.
What types of projects does the FOA expect applicants to propose?
Applications are expected to be organized around collaborative projects that do one or more of the following: (1) characterize and compare mechanisms driving aberrant fibrogenesis across organ systems, (2) study and compare mechanisms of fibrosis resolution (including pathways that stop, reverse, or remodel fibrotic tissue), (3) develop novel therapeutic strategies to prevent, reduce, or resolve organ fibrosis, and/or (4) create new technologies that enable better fibrosis research.
What does the FOA mean by studying "fibrosis resolution"?
In this FOA, fibrosis resolution includes understanding and comparing pathways that stop fibrosis, reverse it, or remodel fibrotic tissue, reflecting interest not only in how fibrosis begins and persists, but also in how it might be actively reversed or repaired.
Are technology development projects encouraged?
Yes. The FOA explicitly includes the creation of new technologies that enable better fibrosis research, such as tools to measure fibrotic burden, track relevant cell populations, profile extracellular matrix remodeling, or model disease processes in more predictive ways.
What grant mechanism is used for this opportunity?
The FOA uses the NIH Research Project Grant (R01) mechanism.
What is the program category and which CFDA numbers are associated with it?
The program is categorized under Health and is associated with NIH CFDA numbers 93.837, 93.838, and 93.839, which align with cardiovascular, lung, and blood-related research portfolios.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
What is the award ceiling listed in the source information?
The listed award ceiling is $350,000, indicating an upper limit on the amount expected per award under the terms described in the provided source information.
Who is eligible to apply?
Eligibility is broad and includes many U.S.-based organization types commonly eligible for NIH grants. Examples listed include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain nonprofits without 501(c)(3) status), small businesses, other for-profit entities, and a range of government entities (state, county, city/township, special district, independent school districts, public housing authorities/Indian housing authorities, and tribal governments or tribal organizations).
Are minority-serving institutions explicitly mentioned as eligible?
Yes. The FOA explicitly notes eligibility for organizations such as Historically Black Colleges and Universities (HBCUs), Tribal Colleges and Universities (TCCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The FOA includes faith-based or community-based organizations among eligible applicants.
Are federal agencies eligible to apply?
Yes. The FOA notes eligible federal agencies among the categories of eligible applicants.
Can a non-U.S. (foreign) institution apply as the applicant organization?
No. The FOA states that non-U.S. (foreign) institutions are not eligible to apply as the applicant organization.
Are non-U.S. components of U.S. organizations eligible to apply?
No. The FOA specifies that non-U.S. components of U.S. organizations are not eligible to apply.
Are any types of international participation allowed?
Yes, in a limited way. While the applicant organization must be U.S.-based, the FOA indicates that foreign components (as defined in the NIH Grants Policy Statement) are allowed, which can permit certain international collaborations under NIH rules.
When was this FOA posted and what are the key dates?
The source record shows the opportunity was posted and created on July 17, 2015. The original and current closing date is October 21, 2016. The archive date is November 21, 2016.
Is this funding opportunity currently open?
No. Based on the provided dates and the archive status, this is an archived FOA rather than an open, active solicitation.
Where can the full announcement be found?
The full announcement is referenced at http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-16-003.html.
Who should be contacted for access or technical issues with the announcement?
For access or technical issues, the contact point listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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