Opportunity Information: Apply for PAR 09 153
Apply for PAR 09 153
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Collaborative R01s for Clinical and Services Studies of Mental Disorders, AIDS and Alcohol Use Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs.
- This funding opportunity was created on May 8, 2012 and posted on Apr 9, 2009.
- Applicants must submit their applications by Sep 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education Special district governments Public housing authorities/Indian housing authorities City or township governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This NIH funding opportunity (PAR 09-153) supports multi-site, collaborative R01 research projects led by the National Institute of Mental Health (NIMH) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The main aim is to fund collaborative intervention trials focused on treatment, prevention, or rehabilitation for people with mental disorders, alcohol use disorders, and especially cases where these conditions occur together. Beyond intervention trials, the announcement also allows a broader set of collaborative clinical studies in related areas such as mental health services research and service delivery questions, AIDS-related research, genetics, psychopathology, stigma, and cultural or social processes that shape mental health and alcohol outcomes. The unifying theme is that the work is clinical or services oriented and truly benefits from being conducted across more than one research site.
A key feature of this FOA is that it is intended for situations where two or more sites are necessary to successfully complete the study. The collaborating sites are expected to share a common, clearly defined protocol, with the multi-site structure used deliberately to accomplish goals that a single site could not meet as well. Common reasons include increasing overall sample size, speeding up participant recruitment, and improving the diversity and representation of the study population across different settings or communities. When the collaboration involves a large number of sites, the agencies expect that one site will take on the role of a coordinating center, handling centralized needs like data management and potentially other administrative functions that keep the entire network aligned.
The funding mechanism is the NIH Collaborative Research Project Grant, commonly described as a linked set of Collaborative R01s. Rather than one single grant covering every location, each site submits its own R01 application and has its own Project Director/Principal Investigator. These separate applications are designed to be interlocked, meaning each one contributes an essential piece of the overall study and is tightly coordinated with the others. In a typical multi-site clinical trial, the same core protocol is anticipated to appear across the linked applications, while still allowing certain responsibilities to be unique to particular sites. For example, one site may take primary responsibility for database management, cross-site quality control, fidelity monitoring, centralized statistical analysis, or final reporting, depending on how the collaboration is organized.
Operationally, the FOA emphasizes the infrastructure needed to make a multi-site study work well. It highlights cross-site coordination, quality control, database management, statistical analysis, and reporting as expected components of a linked collaborative project, especially where multiple sites are enrolling participants or delivering interventions. The intent is to ensure that results are comparable across sites and that the overall dataset can be analyzed as a coherent whole, rather than as disconnected local projects.
In terms of eligibility, the opportunity is broadly available across many organization types. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) organizations), state and local governments (including counties, cities, townships, and special district governments), independent school districts, small businesses, for-profit organizations other than small businesses, public housing authorities, and a wide range of tribal entities and tribal organizations. The eligibility language also extends to various mission-focused and community-serving institutions and organizations, including faith-based and community-based organizations, Historically Black Colleges and Universities, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, U.S. territories or possessions, and even non-U.S. (foreign) organizations and regional organizations, reflecting NIH's broad approach to who can participate when the science and collaborative plan are strong.
Administratively, this is a discretionary grant opportunity under NIH, with activity areas aligned to CFDA 93.242 (Mental Health Research Grants) and 93.273 (Alcohol Research Programs). There is no cost sharing or matching requirement noted. The opportunity was originally posted in April 2009 and later archived, with listed closing dates indicating it is no longer active, but the summary remains useful as a model for how NIH structures linked multi-site R01 clinical and services studies in mental health, alcohol, and related comorbidities, including HIV/AIDS-related clinical questions. The full announcement was hosted through the NIH grants guide, and NIH Office of Extramural Research contact details were provided for technical access issues.
FAQs: NIH PAR 09-153 (Collaborative Multi-Site Linked R01s)
What is PAR 09-153?
PAR 09-153 is an NIH funding opportunity announcement that supported multi-site, collaborative R01 research projects. It was led by the National Institute of Mental Health (NIMH) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and focused on clinical and services-oriented research that benefits from being conducted across more than one research site.
What is the main purpose of this funding opportunity?
The main purpose was to fund collaborative intervention trials focused on treatment, prevention, or rehabilitation for people with mental disorders and alcohol use disorders, with particular emphasis on situations where these conditions co-occur.
Does the opportunity only support intervention trials?
No. While intervention trials were a central focus, the announcement also allowed broader collaborative clinical studies in related areas, as long as the work was clinical or services oriented and clearly benefited from a multi-site design.
What types of studies were considered responsive beyond intervention trials?
The announcement described a broader set of collaborative clinical studies in areas such as mental health services research and service delivery questions, AIDS-related research, genetics, psychopathology, stigma, and cultural or social processes that shape mental health and alcohol-related outcomes.
What is the unifying theme across projects supported by this FOA?
The unifying theme is that the proposed work is clinical or services oriented and is better accomplished through true collaboration across multiple research sites rather than being done at a single site.
How many research sites are expected for a project under this FOA?
The FOA is intended for situations where two or more sites are necessary to successfully complete the study.
Why does NIH emphasize that multiple sites must be necessary?
The FOA is designed for studies where the multi-site structure is deliberately used to achieve goals that a single site could not meet as well, such as increasing sample size, accelerating recruitment, and improving diversity and representation across different settings or communities.
Do collaborating sites need to follow the same study protocol?
Yes. The collaborating sites are expected to share a common, clearly defined protocol. In typical multi-site clinical trials, the same core protocol is anticipated to appear across the linked applications.
Can responsibilities differ across sites even if the core protocol is shared?
Yes. Although the core protocol is expected to be common across the linked R01 applications, certain responsibilities can be unique to particular sites depending on how the collaboration is organized.
What is the funding mechanism used in this opportunity?
The mechanism is the NIH Collaborative Research Project Grant, commonly described as a linked set of Collaborative R01s.
What does it mean that the project uses “linked” Collaborative R01s?
It means each participating site submits its own R01 application and has its own Project Director/Principal Investigator, and the separate applications are designed to be interlocked so that each one contributes an essential piece of the overall study.
Is there one single grant that covers all sites?
No. Rather than one grant covering every location, each site submits a separate R01 application as part of a coordinated, interlocked set.
What types of centralized or cross-site functions are highlighted as important?
The FOA emphasizes infrastructure components needed for successful multi-site work, including cross-site coordination, quality control, database management, statistical analysis, and reporting.
Why are quality control and centralized data approaches emphasized?
The intent is to ensure that results are comparable across sites and that the overall dataset can be analyzed as a coherent whole, rather than as disconnected local projects.
When many sites are involved, is a coordinating center expected?
Yes. When the collaboration involves a large number of sites, NIH expects one site to take on the role of a coordinating center to handle centralized needs like data management and potentially other administrative functions that keep the network aligned.
What are examples of responsibilities a coordinating site might take on?
Examples mentioned include database management, cross-site quality control, fidelity monitoring, centralized statistical analysis, and final reporting, depending on the collaboration’s structure.
Which NIH institutes lead this opportunity?
This FOA is led by the National Institute of Mental Health (NIMH) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What populations or conditions are especially emphasized?
The FOA emphasizes research relevant to people with mental disorders, alcohol use disorders, and especially co-occurring mental health and alcohol-related conditions.
Is HIV/AIDS-related work within scope?
Yes. The announcement explicitly includes AIDS-related research as part of the broader collaborative clinical studies that may be supported when aligned with the FOA’s clinical or services-oriented, multi-site focus.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), state and local governments (including counties, cities, townships, and special district governments), independent school districts, small businesses, for-profit organizations other than small businesses, public housing authorities, and tribal entities and tribal organizations.
Are community-based or faith-based organizations eligible?
Yes. The eligibility language extends to mission-focused and community-serving institutions and organizations, including faith-based and community-based organizations.
Are minority-serving institutions included in eligibility?
Yes. The FOA includes Historically Black Colleges and Universities, Hispanic-serving institutions, tribally controlled colleges and universities, and Alaska Native and Native Hawaiian serving institutions among eligible organization types.
Are U.S. territories or possessions included?
Yes. The eligibility description includes U.S. territories or possessions.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility language explicitly includes non-U.S. (foreign) organizations and regional organizations.
Is cost sharing or matching required?
No cost sharing or matching requirement is noted in the provided summary.
What CFDA areas are associated with this opportunity?
The activity areas are aligned to CFDA 93.242 (Mental Health Research Grants) and 93.273 (Alcohol Research Programs).
Is this funding opportunity still active?
No. The opportunity was originally posted in April 2009 and later archived, with closing dates indicating it is no longer active.
If it is archived, why might the summary still be useful?
The summary remains useful as a model for how NIH structures linked multi-site R01 clinical and services studies in mental health, alcohol, and related comorbidities, including HIV/AIDS-related clinical questions.
Where was the full announcement hosted?
The full announcement was hosted through the NIH grants guide.
Who was listed for help with technical access issues?
NIH Office of Extramural Research contact details were provided for technical access issues related to the full announcement.
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