Opportunity Information: Apply for PA 10 125

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Collaborative Research for Molecular and Genomic Studies of Behavior in Animal Models (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Mar 8, 2010 and posted on Mar 8, 2010.
  • Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Private institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:

The grant opportunity "Collaborative Research for Molecular and Genomic Studies of Behavior in Animal Models (R01)" (Funding Opportunity Number PA 10-125) is a discretionary NIH research grant announced by the National Institute of General Medical Sciences (NIGMS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Its central aim is to move beyond descriptive behavioral findings by supporting projects that directly connect behavior in animal models to underlying molecular biology and genomic mechanisms. The FOA is designed specifically to bring together teams that would not typically work in isolation, pairing behavioral scientists with investigators who have deep expertise in molecular biology and/or genomics so that behavioral questions can be tackled with modern mechanistic tools and datasets.

A defining feature of this announcement is its emphasis on true collaboration and cross-disciplinary integration. The NIH is looking for studies where behavioral phenotypes and experimental paradigms are not an afterthought, and where molecular/genomic profiling is not simply added on for breadth. Instead, the expectation is that behavioral measures and molecular or genomic approaches will be tightly linked in the experimental design to answer clear mechanistic questions about how behavior is generated, regulated, altered, or maintained. The announcement explicitly encourages applications using the multiple-PI approach, which signals that projects led jointly by complementary investigators (for example, one leading behavioral experimentation and another leading molecular/genomic work) are viewed as appropriate and often advantageous for the scientific goals of this FOA.

The funding mechanism is the NIH R01, meaning it supports hypothesis-driven, investigator-initiated research projects that can vary in scope and budget consistent with standard NIH policies for R01 awards. As with many NIH program announcements, the FOA does not guarantee a set number of awards or a fixed pool of money; instead, awards depend on the availability of funds and on whether a sufficient number of applications are judged scientifically meritorious through peer review. In practical terms, that means competitiveness will be driven by the strength of the science, the rigor of the behavioral and molecular/genomic methods, the credibility of the collaborative plan, and the likelihood that the project will yield meaningful mechanistic insight into behavior.

Eligibility under this FOA is broad and includes many organizational types across the academic, nonprofit, and private sectors. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with 501(c)(3) status (and nonprofits without 501(c)(3) status other than institutions of higher education), small businesses, and for-profit organizations other than small businesses. The announcement also lists additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and non-U.S. entities (foreign organizations). There is no cost sharing or matching requirement, which is consistent with many NIH research grant opportunities and reduces administrative barriers for applicants.

From an administrative timeline perspective, this opportunity was posted and created on March 8, 2010, with an original closing date of May 7, 2013 (also listed as the current closing date), and an archive date of June 7, 2013. The Catalog of Federal Domestic Assistance (CFDA) numbers associated with the FOA are 93.859 (Biomedical Research and Research Training) and 93.865 (Child Health and Human Development Extramural Research), reflecting the participating institutes and the broad biomedical relevance of the supported work.

For applicants who want the official, complete details (including any specific instructions, review considerations, required sections, and NIH policy links that typically accompany an R01 FOA), the announcement points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PA-10-125.html. For access or technical issues with the announcement, the listed contact is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

Frequently Asked Questions (FAQs)

What is the name of this grant opportunity?

The opportunity is titled "Collaborative Research for Molecular and Genomic Studies of Behavior in Animal Models (R01)."

What is the funding opportunity number?

The Funding Opportunity Number is PA 10-125.

Which agencies or institutes are associated with this FOA?

This is an NIH discretionary research grant announced by the National Institute of General Medical Sciences (NIGMS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

What is the central goal of the FOA?

The central goal is to move beyond descriptive behavioral findings by supporting projects that directly connect behavior in animal models to underlying molecular biology and genomic mechanisms.

What kind of research approach is this FOA trying to promote?

The FOA promotes cross-disciplinary, mechanistic research where behavioral phenotypes and experimental paradigms are tightly linked to molecular biology and/or genomic approaches in the experimental design.

What does NIH mean by "true collaboration" in this announcement?

It means the project should be integrated across disciplines rather than being split into loosely related parts. Behavioral measures should not be an afterthought, and molecular/genomic profiling should not be included just to add breadth. The expectation is a unified design that answers clear mechanistic questions about behavior.

What types of investigators is NIH trying to bring together?

The FOA is designed to pair behavioral scientists with investigators who have deep expertise in molecular biology and/or genomics, particularly teams that would not typically work together in isolation.

Are applications with multiple principal investigators (multiple PD/PI) allowed or encouraged?

Yes. The FOA explicitly encourages the multiple-PI approach, especially when complementary investigators jointly lead distinct but integrated components (for example, one leading behavioral experimentation and another leading molecular/genomic work).

What is the funding mechanism for this opportunity?

The mechanism is the NIH R01.

What does it mean that this is an R01 mechanism?

It means the FOA supports hypothesis-driven, investigator-initiated research projects that can vary in scope and budget consistent with standard NIH policies for R01 awards.

Does the FOA guarantee a certain number of awards or a fixed amount of funding?

No. Like many NIH program announcements, it does not guarantee a set number of awards or a fixed pool of money. Awards depend on the availability of funds and whether enough applications are judged scientifically meritorious through peer review.

What factors are described as likely to drive competitiveness?

Competitiveness is described as being driven by the strength of the science, the rigor of the behavioral and molecular/genomic methods, the credibility of the collaborative plan, and the likelihood that the project will yield meaningful mechanistic insight into behavior.

What kinds of scientific questions is this FOA interested in?

It is focused on mechanistic questions about how behavior is generated, regulated, altered, or maintained, using animal models and linking behavioral outcomes to molecular and genomic mechanisms.

Who is eligible to apply?

Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with 501(c)(3) status, nonprofits without 501(c)(3) status other than institutions of higher education, small businesses, and for-profit organizations other than small businesses.

Are minority-serving and tribally controlled institutions included in the eligible applicant types?

Yes. The FOA lists additional eligible applicants such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and non-U.S. entities (foreign organizations).

Are foreign organizations eligible to apply?

Yes. The opportunity explicitly includes non-U.S. entities (foreign organizations) among eligible applicants.

Is cost sharing or matching required?

No. The FOA states there is no cost sharing or matching requirement.

When was this opportunity posted and created?

It was posted and created on March 8, 2010.

What is the closing date for this FOA?

The original closing date is May 7, 2013, and it is also listed as the current closing date.

When was the FOA archived?

The archive date is June 7, 2013.

What CFDA numbers are associated with this FOA?

The CFDA numbers are 93.859 (Biomedical Research and Research Training) and 93.865 (Child Health and Human Development Extramural Research).

Where can applicants find the official NIH Grants Guide listing for complete details?

The FOA points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PA-10-125.html.

Who should be contacted for access or technical issues with the announcement?

For access or technical issues, the listed contact is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

What is the intended relationship between behavioral measures and molecular/genomic profiling in proposed projects?

The FOA expects behavioral measures and molecular/genomic approaches to be tightly linked within the experimental design so that the combined work answers clear mechanistic questions about behavior.

Does this FOA focus on descriptive behavioral findings alone?

No. A stated aim is to move beyond descriptive behavioral findings and directly connect behavior to underlying molecular biology and genomic mechanisms.

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