Opportunity Information: Apply for PAR 09 026
Apply for PAR 09 026
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.396 Cancer Biology Research.
- This funding opportunity was created on Mar 16, 2011 and posted on Nov 13, 2008.
- Applicants must submit their applications by Mar 16, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Regional Organizations U.S. Territory or Possession Units of Local Governments.
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Opportunity Summary:
Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01) is a National Cancer Institute (NCI) funding opportunity designed to spark new partnerships that broaden and strengthen two established NCI research communities: the Integrative Cancer Biology Program (ICBP) and the Tumor Microenvironment Network (TMEN). The main idea is to bring together investigators who are already part of either ICBP or TMEN with researchers who are not currently involved in the specific program they want to collaborate with. In practice, applicants are expected to propose genuinely collaborative projects that connect complementary expertise, data, models, technologies, or analytical approaches, with the goal of pushing forward research in integrative cancer biology and/or tumor microenvironment science. The intent is not just to fund another stand-alone cancer project, but to extend the impact of ongoing ICBP and TMEN efforts by introducing new ideas and capabilities from the broader research community.
The research focus emphasizes projects that align with the missions of ICBP or TMEN while also leveraging the existing resources embedded in those communities. That means proposals should make clear how the collaboration will use and build on what is already available through ICBP and TMEN investigators (for example, established experimental systems, computational frameworks, shared datasets, specialized assays, or unique biological models), and then show how the new collaborator(s) will add value through additional methods, expertise, or resources. The overall expectation is that these partnerships will generate insights that are difficult to achieve within a single lab or a single discipline, particularly in areas where understanding cancer requires integrating multiple biological scales (molecules, cells, tissue architecture, and system-level behavior) and where the tumor microenvironment plays a defining role in tumor progression, therapeutic response, and disease evolution.
This opportunity uses the NIH cooperative agreement mechanism (U01), which is distinct from a standard research project grant because it anticipates substantial scientific or programmatic involvement by NIH staff during the life of the award. In a U01 structure, the research team still leads and executes the science, but the NIH typically has an active partnership role, often involving coordination, shared expectations for collaboration, and alignment with program goals. This mechanism fits the FOA’s emphasis on network-enhancing, community-connected projects that add to and interact with existing NCI program investments rather than operating in isolation.
Funding under this FOA is discretionary and contingent on available appropriations and on the receipt of a sufficient number of high-quality, meritorious applications. The announcement does not guarantee a fixed number of awards; instead, it signals that awards will be made depending on both funding availability and the overall strength of the application pool. There is no cost sharing or matching requirement, which reduces barriers for institutions that may not be able to contribute institutional matching funds.
Eligibility is broad and includes many types of organizations that can support biomedical research collaborations. Eligible applicants include private and public institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profits), and state governments. Additional eligible entities also include certain federal agencies, regional organizations, U.S. territories or possessions, and units of local government, as described in the full FOA. The practical takeaway is that the program is designed to allow cross-sector partnerships as long as the proposed collaboration meaningfully connects ICBP or TMEN-associated investigators with external collaborators and remains aligned with the scientific priorities of integrative cancer biology and tumor microenvironment research.
Key administrative details associated with the archived notice include Funding Opportunity Number PAR-09-026, with posting dated November 13, 2008. The FOA is associated with CFDA listings 93.393 (Cancer Cause and Prevention Research), 93.394 (Cancer Detection and Diagnosis Research), and 93.396 (Cancer Biology Research). The opportunity is archived (with archive date April 16, 2011), and the linked source for the full announcement was provided through the NIH Grants Guide. For technical issues accessing the announcement, the notice directs users to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
What is the purpose of the "Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01)" opportunity?
This National Cancer Institute (NCI) funding opportunity is meant to spark new partnerships that broaden and strengthen two established NCI research communities: the Integrative Cancer Biology Program (ICBP) and the Tumor Microenvironment Network (TMEN). The emphasis is on creating collaborative projects that extend the impact of ongoing ICBP and TMEN efforts by bringing in new ideas, capabilities, and collaborators.
Which NCI programs does this funding opportunity connect?
It is specifically designed to connect and strengthen the Integrative Cancer Biology Program (ICBP) and the Tumor Microenvironment Network (TMEN), including collaborations that use and build on resources already present in those communities.
Who is this program trying to bring together in a collaboration?
The intent is to bring together investigators who are already part of either ICBP or TMEN with researchers who are not currently involved in the specific program they want to collaborate with. In other words, projects should meaningfully connect ICBP- or TMEN-associated investigators with external collaborators who add complementary value.
What kind of projects is this FOA looking for?
The FOA emphasizes genuinely collaborative projects that connect complementary expertise, data, models, technologies, or analytical approaches to advance integrative cancer biology and/or tumor microenvironment science. Projects are expected to be more than stand-alone cancer studies; they should actively extend and interact with existing ICBP and TMEN efforts.
What does "integrative cancer biology" mean in the context of this opportunity?
Within this opportunity, integrative cancer biology is framed as research that benefits from integrating multiple biological scales, such as molecules, cells, tissue architecture, and system-level behavior. The goal is to generate insights that are difficult to achieve within a single lab or a single discipline.
Why is the tumor microenvironment highlighted as a priority area?
The FOA underscores that the tumor microenvironment can play a defining role in tumor progression, therapeutic response, and disease evolution. Projects that address these aspects in a way that aligns with ICBP or TMEN missions are central to the opportunity.
How should applicants use existing ICBP and TMEN resources?
Proposals are expected to clearly describe how the collaboration will use and build on existing ICBP and TMEN resources. Examples mentioned include established experimental systems, computational frameworks, shared datasets, specialized assays, or unique biological models. Applications should also explain how the new collaborator(s) will add additional methods, expertise, or resources on top of what is already available.
Is this opportunity intended to fund typical stand-alone cancer research projects?
No. The stated intent is not simply to fund another stand-alone cancer project. Instead, projects should extend the impact of ongoing ICBP and TMEN efforts through network-enhancing, community-connected collaborations that introduce new capabilities and ideas.
What funding mechanism is used for this opportunity?
This FOA uses the NIH cooperative agreement mechanism (U01).
How is a U01 cooperative agreement different from a standard research project grant?
A U01 anticipates substantial scientific or programmatic involvement by NIH staff during the life of the award. The research team still leads and executes the science, but NIH typically has an active partnership role. This often includes coordination, shared expectations for collaboration, and alignment with program goals.
Why is the U01 mechanism a good fit for this FOA?
The U01 structure matches the FOA's emphasis on collaborations that enhance and interact with existing NCI program investments (ICBP and TMEN) rather than operating in isolation, and it supports the expectation of coordination and alignment with broader program goals.
Is funding guaranteed, or is the number of awards fixed?
No. Funding under this FOA is discretionary and depends on available appropriations and the receipt of a sufficient number of high-quality, meritorious applications. The announcement does not guarantee a fixed number of awards.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What types of organizations are eligible to apply?
Eligibility is broad and includes many types of organizations that can support biomedical research collaborations. Eligible applicants include private and public institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profits), and state governments.
Are any other entities eligible besides universities, nonprofits, and companies?
Yes. The information provided also notes that certain federal agencies, regional organizations, U.S. territories or possessions, and units of local government (as described in the full FOA) are eligible entities.
Does the FOA encourage cross-sector partnerships?
Yes. The practical takeaway described is that the program is designed to allow cross-sector partnerships, as long as the proposed collaboration meaningfully connects ICBP or TMEN investigators with external collaborators and aligns with the scientific priorities of integrative cancer biology and tumor microenvironment research.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is PAR-09-026.
When was this FOA posted, and what is its status?
The archived notice lists a posting date of November 13, 2008. The opportunity is archived, with an archive date of April 16, 2011.
Which CFDA listings are associated with this funding opportunity?
The FOA is associated with CFDA listings 93.393 (Cancer Cause and Prevention Research), 93.394 (Cancer Detection and Diagnosis Research), and 93.396 (Cancer Biology Research).
Where was the full announcement linked from?
The linked source for the full announcement was provided through the NIH Grants Guide.
What should someone do if they have technical issues accessing the announcement?
For technical issues accessing the announcement, the notice directs users to the NIH Office of Extramural Research (OER) webmaster contact.
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| NIDA Research Center of Excellence Grant Program (P50) Apply for PAR 08 046 Funding Number: PAR 08 046 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIDA Core Center of Excellence Grant Program (P30) Apply for PAR 08 073 Funding Number: PAR 08 073 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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