Opportunity Information: Apply for PAR 11 146
Apply for PAR 11 146
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.396 Cancer Biology Research.
- This funding opportunity was created on Mar 16, 2011 and posted on Mar 16, 2011.
- Applicants must submit their applications by Oct 19, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Independent school districts State governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public housing authorities/Indian housing authorities Small businesses Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The grant opportunity titled "Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01)" (Funding Opportunity Number PAR-11-146) is a National Cancer Institute (NCI) initiative under the National Institutes of Health that aims to spark new, meaningful collaborations in cancer research. The core idea is to connect investigators who are already part of two established NCI communities, the Integrative Cancer Biology Program (ICBP) and the Tumor Microenvironment Network (TMEN), with researchers who are not currently involved in the specific program they want to collaborate with. In other words, the FOA is structured to bring fresh partners into existing NCI-supported ecosystems so that ongoing work in integrative cancer biology and tumor microenvironment science can be extended, challenged, and strengthened by new perspectives and capabilities.
This FOA emphasizes projects that are genuinely collaborative rather than simply parallel efforts under one umbrella. Proposed studies are expected to align clearly with the missions of ICBP and/or TMEN, meaning they should address cancer as a complex, multiscale biological system and/or focus on how tumors interact with their surrounding environment, including stromal cells, immune components, extracellular matrix, vasculature, and signaling factors that shape tumor growth, invasion, and treatment response. A key expectation is that applicants will not only propose new research aims, but will also explicitly leverage the resources, data, tools, and specialized expertise already present within the ICBP and TMEN communities. The intent is to amplify what those programs can do by adding new ideas, methods, technologies, and complementary resources from collaborators outside the immediate program network.
The funding mechanism is a U01 cooperative agreement, which typically indicates substantial scientific or programmatic involvement by the NIH compared with a standard research project grant. In practical terms, a cooperative agreement often comes with more active coordination, shared expectations for collaboration, and closer engagement with NCI program staff to ensure the project is executed in a way that serves broader program goals. The activity categories listed for the opportunity fall under education and health, and the relevant CFDA numbers reflect NCI areas spanning cancer cause and prevention research (93.393), cancer detection and diagnosis research (93.394), and cancer biology research (93.396). The opportunity does not require cost sharing or matching, which removes a common administrative barrier for many institutions.
Eligibility is broad and includes a wide range of organizations and institution types. Academic applicants can include public and state-controlled institutions of higher education as well as private institutions of higher education. Eligible non-academic entities include nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses and other than small businesses), and many levels of government organizations, such as state governments, county governments, city or township governments, special district governments, and public housing authorities/Indian housing authorities. The FOA also explicitly allows participation from tribal governments (both federally recognized and other than federally recognized), tribally controlled colleges and universities, and regional organizations. It extends eligibility to U.S. territories or possessions and includes provisions that allow non-U.S. entities (foreign organizations) as well as foreign components of U.S. organizations, which can be important for teams seeking specialized international expertise, cohorts, or technologies.
From a timing standpoint, the FOA was posted and created on March 16, 2011, with an original and current closing date of October 19, 2011, and an archive date of November 19, 2011. While these dates indicate the opportunity is historical, the structure of the announcement still provides a clear picture of what NCI was seeking: cooperative, cross-network collaborations that build directly on ICBP and TMEN strengths, expand the reach of those programs, and accelerate progress in understanding cancer biology through integrative approaches and tumor microenvironment-focused science.
For additional details, the announcement provided an official link through the NIH grants guide (http://grants.nih.gov/grants/guide/pa-files/PAR-11-146.html) and listed NIH Office of Extramural Research support contacts for access or linking issues.
Frequently Asked Questions (FAQs)
1. What is the full title of this grant opportunity?
The opportunity is titled "Collaborative Research in Integrative Cancer Biology and the Tumor Microenvironment (U01)."
2. What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is PAR-11-146.
3. Which agency is offering this funding opportunity?
This is a National Cancer Institute (NCI) initiative under the National Institutes of Health (NIH).
4. What is the main goal of this FOA?
The main goal is to spark new, meaningful collaborations in cancer research by connecting investigators from two established NCI communities (ICBP and TMEN) with researchers who are not currently involved in the specific program they want to collaborate with.
5. Which NCI research communities are specifically involved?
The FOA is centered on the Integrative Cancer Biology Program (ICBP) and the Tumor Microenvironment Network (TMEN).
6. What kind of collaborations does the FOA aim to create?
The FOA is structured to bring fresh partners into existing NCI-supported ecosystems, so ongoing work in integrative cancer biology and tumor microenvironment science can be extended, challenged, and strengthened by new perspectives and capabilities.
7. Are projects expected to be truly collaborative, or can they be separate efforts grouped together?
The FOA emphasizes projects that are genuinely collaborative rather than parallel efforts operating under one umbrella.
8. What scientific areas should proposed studies align with?
Proposed studies are expected to align clearly with the missions of ICBP and/or TMEN. This includes addressing cancer as a complex, multiscale biological system and/or focusing on how tumors interact with their surrounding environment.
9. What topics are included under “tumor microenvironment” in this FOA?
The FOA highlights tumor interactions with surrounding components such as stromal cells, immune components, extracellular matrix, vasculature, and signaling factors that influence tumor growth, invasion, and treatment response.
10. What is a key expectation for how applicants will use existing program strengths?
Applicants are expected to explicitly leverage the resources, data, tools, and specialized expertise already present within the ICBP and TMEN communities.
11. What is the intended benefit of bringing in collaborators from outside the immediate program network?
The intent is to amplify what ICBP and TMEN can do by adding new ideas, methods, technologies, and complementary resources from collaborators outside the immediate program network.
12. What funding mechanism is used for this opportunity?
The funding mechanism is a U01 cooperative agreement.
13. What does it mean that this is a U01 cooperative agreement?
A cooperative agreement typically indicates substantial scientific or programmatic involvement by NIH compared with a standard research project grant. It often involves more active coordination, shared expectations for collaboration, and closer engagement with NCI program staff to ensure the project supports broader program goals.
14. What activity categories are associated with this opportunity?
The activity categories listed for the opportunity fall under education and health.
15. Which CFDA numbers are associated with this FOA, and what do they relate to?
The relevant CFDA numbers are 93.393 (cancer cause and prevention research), 93.394 (cancer detection and diagnosis research), and 93.396 (cancer biology research).
16. Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
17. What types of academic institutions are eligible to apply?
Eligible academic applicants include public and state-controlled institutions of higher education as well as private institutions of higher education.
18. Are nonprofit organizations eligible?
Yes. Nonprofits are eligible, including those with or without 501(c)(3) status.
19. Are for-profit organizations eligible?
Yes. For-profit organizations are eligible, including small businesses and organizations other than small businesses.
20. Are government organizations eligible to apply?
Yes. Eligibility includes many levels of government organizations, such as state governments, county governments, city or township governments, special district governments, and public housing authorities/Indian housing authorities.
21. Are tribal entities eligible?
Yes. The FOA explicitly allows participation from tribal governments (both federally recognized and other than federally recognized), tribally controlled colleges and universities, and regional organizations.
22. Are U.S. territories or possessions included in eligibility?
Yes. The eligibility language extends to U.S. territories or possessions.
23. Are non-U.S. (foreign) organizations allowed to participate?
Yes. The FOA includes provisions that allow non-U.S. entities (foreign organizations) as well as foreign components of U.S. organizations.
24. Why might foreign organizations or foreign components be relevant for projects under this FOA?
The FOA notes that foreign participation can matter for teams seeking specialized international expertise, cohorts, or technologies.
25. When was this FOA posted and created?
The FOA was posted and created on March 16, 2011.
26. What were the closing dates for this opportunity?
The original and current closing date listed is October 19, 2011.
27. When was this opportunity archived?
The archive date is November 19, 2011.
28. Is this a current funding opportunity?
Based on the closing and archive dates provided (2011), this opportunity appears to be historical.
29. Even if historical, what does this FOA’s structure indicate NCI was seeking?
It indicates NCI was seeking cooperative, cross-network collaborations that build directly on ICBP and TMEN strengths, expand the reach of those programs, and accelerate progress in understanding cancer biology through integrative approaches and tumor microenvironment-focused science.
30. Where is the official FOA posted online?
An official NIH Grants Guide link is provided: http://grants.nih.gov/grants/guide/pa-files/PAR-11-146.html
31. Who is listed for help with access or linking issues?
The announcement lists NIH Office of Extramural Research support contacts for access or linking issues (specific names or details are not included in the provided information).
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| New Technology for Proteomics and Glycomics (SBIR R43/R44) Apply for PA 11 215 Funding Number: PA 11 215 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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