Opportunity Information: Apply for RFA NS 13 013
Apply for RFA NS 13 013
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Collaborative Research on Chronic Traumatic Encephalopathy and Delayed Effects of Traumatic Brain Injury Neuropathology and Neuroimaging Correlation (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.279 Drug Abuse and Addiction Research Programs 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Mar 29, 2013 and posted on Mar 13, 2013.
- Applicants must submit their applications by May 14, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: For profit organizations other than small businesses Public housing authorities/Indian housing authorities Small businesses City or township governments State governments Independent school districts Special district governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This NIH funding opportunity (RFA-NS-13-013) supported a single, multicenter collaborative project to carry out a systematic and comprehensive investigation of the brain pathology associated with Chronic Traumatic Encephalopathy (CTE) and other delayed effects of traumatic brain injury (TBI). The core idea was to use well-characterized postmortem biospecimens together with rigorous histological methods and neuroimaging correlation to strengthen the biological foundation needed for future work, particularly the longer-term goal of developing reliable in vivo diagnostic approaches (for example, imaging or other biomarkers that could identify disease during life rather than only at autopsy). The award mechanism was a U01 cooperative agreement, meaning NIH staff were expected to have substantial involvement in project coordination and scientific direction, which fits the emphasis on standardization, data harmonization, and coordinated work across multiple sites.
The scientific scope centered on connecting what can be seen in the brain after death (neuropathology) with what can be measured using imaging tools, aiming to clarify how repetitive head impacts and/or prior TBI relate to later-life neurodegenerative changes. By emphasizing postmortem biospecimens, the opportunity focused on establishing ground truth: detailed tissue-based characterization that can be compared against neuroimaging findings collected during life or available near the end of life. In practical terms, this kind of program typically prioritizes consistent tissue processing and staining methods, uniform pathological criteria, careful clinical and exposure-history annotation, and agreed-upon imaging analysis pipelines so that findings from different centers can be meaningfully compared and combined.
Administratively, this was a discretionary federal grant opportunity in the health research area, offered by the National Institutes of Health, with an expected total funding level of about $2.5 million and an anticipated number of awards of one. There was no cost-sharing or matching requirement. The application window reflected a 2013 cycle: it was posted March 13, 2013, with an original and current closing date of May 14, 2013, and it was archived June 14, 2013.
Eligibility was broad across many U.S.-based organization types, reflecting NIH’s typical goal of encouraging strong scientific teams regardless of sector. Eligible applicants included public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), for-profit organizations (including small businesses), and a range of government entities (state, county, city or township, special district, and independent school districts), as well as public housing authorities and tribal organizations. The announcement also explicitly included categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American, Native American, and Pacific Islander-serving institutions, along with faith-based and community-based organizations and eligible federal agencies. Foreign institutions and non-U.S. components of U.S. organizations were not eligible to apply, although foreign components (as defined in NIH policy) were allowed, which generally means discrete elements of a larger project may be conducted internationally when justified, while the applicant organization remains U.S.-based.
The program was associated with multiple CFDA numbers spanning neuroscience and related research areas, including 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) among others listed in the announcement. For access to the full archived solicitation details, NIH referenced the guide notice link at http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-13-013.html, and provided contact support through the NIH Office of Extramural Research (OER) webmaster for technical issues accessing or linking to the announcement.
Frequently Asked Questions (FAQs)
What is this NIH funding opportunity (RFA-NS-13-013) about?
This NIH opportunity supported a single, multicenter collaborative project designed to conduct a systematic and comprehensive investigation of brain pathology associated with Chronic Traumatic Encephalopathy (CTE) and other delayed effects of traumatic brain injury (TBI).
What was the main scientific goal of the project?
The central goal was to strengthen the biological foundation needed for future research by linking detailed postmortem neuropathology (what is seen in brain tissue after death) with neuroimaging correlation (what can be measured using imaging tools), with an eye toward enabling future development of reliable in vivo diagnostics such as imaging-based approaches or other biomarkers.
Why did the opportunity emphasize postmortem biospecimens?
The focus on well-characterized postmortem biospecimens was intended to establish "ground truth" through rigorous tissue-based characterization. This provides a reference standard that can be compared against neuroimaging findings collected during life or near the end of life.
How does neuroimaging correlation fit into the scope?
The program aimed to connect neuropathology observed after death with imaging measures, to clarify how repetitive head impacts and/or prior TBI relate to later-life neurodegenerative changes and to support longer-term work on diagnostic tools that could identify disease during life.
What kinds of methods and practices were typically prioritized in this program?
Based on the stated emphasis, the work typically prioritized consistent tissue processing and staining methods, uniform pathological criteria, careful clinical and exposure-history annotation, and agreed-upon imaging analysis pipelines so that data and findings across centers could be meaningfully compared and combined.
What is the award mechanism for this opportunity?
The mechanism was a U01 cooperative agreement.
What does a U01 cooperative agreement mean in practice?
A U01 cooperative agreement indicates that NIH staff were expected to have substantial involvement in project coordination and scientific direction. In this opportunity, that involvement aligned with the emphasis on standardization, data harmonization, and coordinated work across multiple sites.
How many awards were anticipated?
The anticipated number of awards was one, supporting a single multicenter collaborative project.
What was the expected total funding level?
The expected total funding level was about $2.5 million.
Was cost sharing or matching required?
No. The opportunity specified that there was no cost-sharing or matching requirement.
Which federal agency offered this opportunity?
The opportunity was offered by the National Institutes of Health (NIH).
What kind of grant opportunity was this administratively?
It was a discretionary federal grant opportunity in the health research area.
When was this opportunity posted and when did it close?
It was posted on March 13, 2013. The original and current closing date was May 14, 2013.
Is this funding opportunity still active?
No. The announcement was archived on June 14, 2013.
Who was eligible to apply?
Eligibility was broad across many U.S.-based organization types, including public and private institutions of higher education; nonprofit organizations (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status); for-profit organizations (including small businesses); and many government entities (state, county, city or township, special district, and independent school districts), as well as public housing authorities and tribal organizations.
Did the eligibility list include specific institution categories such as minority-serving institutions?
Yes. The announcement explicitly included categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and Asian American, Native American, and Pacific Islander-serving institutions. It also included faith-based and community-based organizations and eligible federal agencies.
Were foreign institutions eligible to apply?
No. Foreign institutions and non-U.S. components of U.S. organizations were not eligible to apply.
Are foreign components allowed under this opportunity?
Yes. Foreign components (as defined in NIH policy) were allowed, meaning discrete elements of a larger project could be conducted internationally when justified, while the applicant organization remained U.S.-based.
What research topics did the program aim to clarify?
The scientific scope centered on clarifying how repetitive head impacts and/or prior TBI relate to later-life neurodegenerative changes, by connecting postmortem neuropathology with neuroimaging correlation.
What CFDA numbers were associated with this program?
The program was associated with multiple CFDA numbers spanning neuroscience and related research areas, including 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders), among others listed in the announcement.
Where can someone find the full archived solicitation details?
NIH referenced an archived guide notice link for the full solicitation details: http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-13-013.html.
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, NIH provided contact support through the NIH Office of Extramural Research (OER) webmaster.
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