Collaborative Studies on The Central Nervous System and Glycemia (R01) | Apply Online

Opportunity Summary:

The NIH grant opportunity titled "Collaborative Studies on The Central Nervous System and Glycemia (R01)" (Funding Opportunity Number PAS-11-029) is designed to push forward research at the intersection of neuroscience and diabetes/metabolism. Its central goal is to spark new, genuinely interdisciplinary collaborations that can explain two closely linked issues: first, how the central nervous system (CNS) helps regulate glucose levels in the body, and second, what happens to the CNS when those glucose-control mechanisms are disrupted. In practical terms, the FOA is interested both in the brain and nervous system as active regulators of glycemia and in the neurological consequences that can arise when glycemic control is impaired, which is highly relevant to conditions like diabetes and related metabolic disorders.

The sponsoring agencies are two NIH institutes whose missions naturally meet at this crossroads: the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). By issuing the FOA jointly, these institutes are signaling that proposals should not sit entirely within one traditional lane (pure neuroscience or pure metabolism research), but instead should integrate expertise, methods, and perspectives from both areas. The emphasis on collaboration matters because many of the most important questions in neuro-metabolic regulation require combined skill sets, such as neural circuit analysis alongside endocrine and metabolic phenotyping, or studies of how altered glucose homeostasis affects brain function, structure, or disease vulnerability.

This program uses the standard NIH Research Project Grant (R01) mechanism, meaning applicants are expected to propose a well-developed, hypothesis-driven research plan with clear aims, rigorous methods, and a feasible project structure. The R01 mechanism also implies that projects can support substantial multi-year research programs, including personnel, supplies, and other project costs typical for a major NIH research award, with flexibility in how the project is organized depending on scientific needs.

In terms of funding scale and expected awards, the FOA indicates that up to $750,000 in first-year direct costs is available, and NIH anticipated making about two to three new R01 awards per year over the three-year run of the announcement. Because projects may differ widely in scope, complexity, and duration, the FOA explicitly notes that award size and project length may vary between funded applications. The final number of awards and the total dollars actually awarded would ultimately depend on the quality of applications received, the proposed budgets, and the duration and scientific merit of the proposed work.

Administratively, this is a discretionary grant opportunity under NIH, with activity categories tied to health and nutrition and indexed to CFDA program numbers 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research) and 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders). The opportunity does not require cost sharing or matching, which aligns with typical NIH R01 expectations. Key dates listed include a posted and creation date of November 12, 2010, an original and current closing date of January 7, 2014, and an archive date of February 7, 2014, indicating the FOA is no longer active but remains available for reference.

Eligibility is broad and includes many types of domestic applicants such as public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status in certain cases), for-profit organizations other than small businesses, small businesses, state and local governments, tribal governments and tribal organizations, school districts, public housing authorities/Indian housing authorities, and special district governments. The eligibility language also extends to a variety of specifically named categories, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, and certain non-U.S. entities such as foreign organizations and regional organizations. In short, NIH structured the FOA to allow applications from a wide range of research-capable institutions, including those serving underrepresented communities and, where appropriate, international entities.

For applicants seeking the full announcement details, the FOA points to the NIH Grants Guide page (http://grants.nih.gov/grants/guide/pa-files/PAS-11-029.html). It also provides support contacts through the NIH Office of Extramural Research (OER) webmaster for technical access or linking problems (FBOWebmaster@OD.NIH.GOV).

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