Opportunity Information: Apply for PA 16 134

  • The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Collaborative Supplements for Cryo-Electron Microscopy Technology Transfer (Admin Supp)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
  • This funding opportunity was created on Mar 15, 2016 and posted on Mar 15, 2016.
  • Applicants must submit their applications by Jun 07, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The number of recipients for this funding is limited to 13 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for PA 16 134

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Opportunity Summary:

The funding opportunity titled "Collaborative Supplements for Cryo-Electron Microscopy Technology Transfer (Admin Supp)" (Funding Opportunity Number PA 16 134) is a discretionary NIH grant mechanism designed to help qualified research laboratories build practical, independent capability in high-resolution cryo-electron microscopy (cryoEM), specifically single-particle analysis. The central idea is technology transfer through a hands-on collaboration: an applicant lab that has solid background experience in structural biology or a closely related field partners with an established cryoEM lab that already has deep expertise and infrastructure. Together, the two groups are expected to carry out real cryoEM projects and solve structures of novel but tractable specimens, using the process as a structured training pipeline rather than as a purely service-based arrangement.

This supplement is meant to accelerate the applicant lab's transition into being able to run cryoEM projects with increasing independence. Over one to two years of support, the applicant lab should gain working competence in the basics of cryoEM at a moderate skill level and, importantly, get direct experience across the full workflow. That generally implies exposure not only to data collection, but also to sample preparation, grid handling, microscope operation practices as appropriate, image processing, reconstruction, validation, and interpretation, culminating in a solved structure as a tangible outcome. In other words, the goal is capacity building that results in a demonstrable scientific product, while leaving the applicant lab better positioned to continue cryoEM work beyond the supplement period.

The opportunity falls under the health funding activity category and is associated with CFDA number 93.859. It is administered by HHS/NIH (listed as HHS-NIH11 in the source data). A wide range of applicant organizations are eligible, including various levels of government entities, public and private institutions of higher education, federally recognized tribal governments and other tribal organizations, public housing authorities/Indian housing authorities, nonprofits (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), and small businesses, with an additional eligibility clarification referenced in the original listing. The posted and creation dates are March 15, 2016, with an original and current closing date of June 7, 2016. The listing notes an expected 13 awards; the award ceiling is not specified in the provided source data.

In practical terms, the program is aimed at labs that are not starting from zero in structural science, but that need a structured, collaborative on-ramp into cryoEM single-particle analysis. It emphasizes learning-by-doing with an expert partner, producing at least one solved structure, and building a sustainable base of skills that can support future independent cryoEM research.

Frequently Asked Questions (FAQs)

What is the title and funding opportunity number for this grant?

The opportunity is titled "Collaborative Supplements for Cryo-Electron Microscopy Technology Transfer (Admin Supp)" and the Funding Opportunity Number is PA 16 134.

What is the main purpose of this funding opportunity?

The purpose is to help qualified research laboratories build practical, independent capability in high-resolution cryo-electron microscopy (cryoEM), specifically single-particle analysis, through hands-on technology transfer and collaboration with an established cryoEM lab.

What kind of support mechanism is this?

This is a discretionary NIH grant mechanism offered as an administrative supplement ("Admin Supp") focused on collaborative technology transfer.

What does "technology transfer" mean in this program?

In this program, technology transfer is structured as a hands-on collaboration where an applicant lab partners with an expert cryoEM lab to learn the full cryoEM workflow by carrying out real cryoEM projects together, rather than relying on a purely service-based arrangement.

Who is this program designed for?

It is aimed at laboratories that already have a solid background in structural biology or a closely related field, but do not yet have independent, practical capability in cryoEM single-particle analysis and need a structured on-ramp to build that capability.

Is this opportunity intended for labs starting from scratch in cryoEM or structural science?

No. The program is described as being for labs that are not starting from zero in structural science, but that need structured training and collaboration to transition into cryoEM single-particle analysis.

What is the expected collaboration model?

The applicant lab partners with an established cryoEM lab that already has deep expertise and infrastructure. The two groups are expected to work together on real cryoEM projects, using the work as a training pipeline for the applicant lab.

Does the program support a service-only cryoEM arrangement?

No. The program emphasizes learning-by-doing and building capability in the applicant lab, rather than operating as a purely service-based arrangement where the expert lab performs the work without structured training and transfer of skills.

What technical area of cryoEM is emphasized?

The opportunity specifically focuses on high-resolution cryo-electron microscopy for single-particle analysis.

What outcomes are expected from the collaboration?

The collaboration is expected to produce tangible scientific results while building the applicant lab's independent capability. A key stated outcome is solving structures of novel but tractable specimens, culminating in at least one solved structure as a demonstrable product.

What types of specimens are expected to be used?

The program describes solving structures of "novel but tractable specimens," meaning the targets should be new but feasible to solve within the collaboration and timeframe.

What skills is the applicant lab expected to gain?

Over the support period, the applicant lab is expected to gain working competence at a moderate skill level in the basics of cryoEM and receive direct experience across the full workflow. The description includes exposure to sample preparation, grid handling, microscope operation practices as appropriate, data collection, image processing, reconstruction, validation, and interpretation.

Is the goal to make the applicant lab fully independent by the end of the supplement?

The goal is to accelerate the transition toward increasing independence. The program emphasizes building a sustainable base of skills and practical experience so the applicant lab is better positioned to continue cryoEM work beyond the supplement period.

How long is the expected support period?

The opportunity describes support over one to two years.

Which agency administers this opportunity?

The opportunity is administered by HHS/NIH (listed as HHS-NIH11 in the source data).

What is the funding activity category?

The opportunity falls under the health funding activity category.

What is the CFDA number associated with this opportunity?

The associated CFDA number is 93.859.

Who is eligible to apply?

A wide range of organizations are eligible, including various levels of government entities; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); and small businesses. The listing also notes an additional eligibility clarification referenced in the original listing.

Are small businesses eligible?

Yes. Small businesses are listed among the eligible applicant types.

Are for-profit organizations eligible?

Yes. For-profit organizations (other than small businesses) are listed as eligible, and small businesses are also listed as eligible.

Are nonprofit organizations eligible?

Yes. Both 501(c)(3) and non-501(c)(3) nonprofits are listed as eligible.

Are tribal governments and tribal organizations eligible?

Yes. Federally recognized tribal governments and other tribal organizations are included in the eligible applicant types.

Are institutions of higher education eligible?

Yes. Both public and private institutions of higher education are listed as eligible.

Are government entities eligible?

Yes. Various levels of government entities are listed among eligible applicants.

Is the award amount (ceiling) specified?

No. The award ceiling is not specified in the provided source data.

How many awards are expected?

The listing notes an expected 13 awards.

What are the posted and closing dates for this opportunity?

The posted date and creation date are March 15, 2016. The original and current closing date is June 7, 2016.

What is the core idea behind the supplement's training approach?

The core idea is capacity building through structured, hands-on collaboration: the applicant lab learns by actively participating in real cryoEM single-particle projects alongside an established cryoEM lab, gaining experience across the end-to-end workflow and producing a solved structure as evidence of capability.

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