Opportunity Information: Apply for RFA GM 13 003
Apply for RFA GM 13 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Competing Revisions for Macromolecular Interactions in Cells (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Jan 27, 2012 and posted on Jan 27, 2012.
- Applicants must submit their applications by Oct 18, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,200,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $80,000.00 in funding.
- Eligible applicants include: City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Private institutions of higher education Small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH National Institute of General Medical Sciences (NIGMS) funding opportunity "Competing Revisions for Macromolecular Interactions in Cells (R01)" (Funding Opportunity Number RFA-GM-13-003) was designed to let investigators expand the scope and technical reach of NIGMS projects that were already funded as R01 or R37 awards. Instead of supporting brand-new grants, this announcement focused on competitive revisions (what used to be called competing supplements) to active awards, with the central scientific theme being macromolecular interactions in cellular contexts and how those interactions relate to biological function. In practical terms, the FOA encouraged researchers who were already studying molecular systems and mechanisms in living organelles, cells, tissues, or whole organisms to propose a substantial, peer-reviewed expansion of what their current grant could do, either by pursuing additional aims that build logically from the parent project or by adding new methods that significantly strengthen the project’s ability to analyze macromolecular interactions in vivo.
A key goal was diversification and capability-building. NIGMS signaled that it wanted projects to go beyond their current boundaries in ways that improve the field’s ability to observe, measure, and interpret interactions among proteins, nucleic acids, complexes, and other cellular macromolecules under conditions that preserve biological context. The FOA explicitly allowed applicants to request an increased budget for the revision, reflecting the reality that certain experimental approaches (for example, advanced live-cell imaging, specialized biophysical measurements, or other resource-intensive techniques) can be financially difficult to add under an existing budget. One stated priority was enabling modestly funded laboratories to gain access to approaches and research objectives that would otherwise be out of reach, which is another way of saying the program aimed to lower the barrier to entry for technically demanding, cell-relevant interaction studies.
Collaboration was presented as optional rather than mandatory. Applicants could carry out the expanded work entirely within their own laboratories if they had the expertise and infrastructure, but the FOA also permitted and supported collaborative arrangements, including subcontracts, when another investigator could provide complementary skills, instrumentation, or experimental systems. This structure made it possible for a parent R01/R37 team to add a new capability quickly by partnering with groups that already had specialized platforms or know-how, while still keeping the revision anchored to the original funded project and its scientific foundation.
From an administrative standpoint, this was a discretionary grant opportunity in the NIH health research category (CFDA 93.859, Biomedical Research and Research Training). It did not require cost sharing or matching. The announcement was posted January 27, 2012, with an original and current closing date of October 18, 2012, and it was archived November 18, 2012. The estimated total funding listed for the initiative was $3.2 million, and the award ceiling was $80,000, indicating that individual competitive revisions were expected to be relatively targeted expansions rather than large-scale, multi-million-dollar additions.
Eligibility was broad and included a wide range of domestic and non-domestic organizations. Eligible applicants spanned federal, state, local, and tribal governments; public and private institutions of higher education; nonprofits (including those with and without 501(c)(3) status); for-profit organizations (including small businesses); independent school districts; and public housing authorities/Indian housing authorities. The eligibility language also explicitly included a variety of institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, and regional organizations. Foreign institutions were eligible to apply, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed consistent with NIH policy, which underscores that the science focus, rather than geography, was a central consideration.
Overall, the opportunity can be read as a targeted mechanism to strengthen ongoing NIGMS-funded research by letting active R01 and R37 projects add new scientific dimensions and technical capabilities specifically aimed at understanding how macromolecular interactions operate inside cells and how those interactions drive function. The combination of (1) being tied to an existing award, (2) allowing budget increases up to a defined ceiling, (3) permitting but not requiring collaboration, and (4) prioritizing access for less-resourced labs reflects a program built to accelerate meaningful methodological or scope expansions without requiring investigators to wait for an entirely new grant cycle to pursue the next logical step in their research.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity is titled "Competing Revisions for Macromolecular Interactions in Cells (R01)." It was issued by the NIH National Institute of General Medical Sciences (NIGMS).
What is the Funding Opportunity Number (FOA number)?
The FOA number is RFA-GM-13-003.
What type of application does this announcement support?
This announcement supports competitive revisions (previously called competing supplements) to active NIGMS-funded awards, rather than brand-new, standalone grants.
Which parent awards are eligible for a competing revision under this FOA?
The FOA was designed for investigators who already held active NIGMS projects funded as R01 or R37 awards.
What is the main scientific focus of the opportunity?
The central theme is macromolecular interactions in cellular contexts and how those interactions relate to biological function. The emphasis is on studying interactions among proteins, nucleic acids, complexes, and other macromolecules under conditions that preserve biological context.
Does the FOA support work in living systems, or only in vitro studies?
Based on the description, the FOA emphasized macromolecular interactions in vivo and in cellular contexts. It specifically encouraged studies of molecular systems and mechanisms in living organelles, cells, tissues, or whole organisms.
What kinds of expansions were encouraged for the revision?
The FOA encouraged substantial, peer-reviewed expansions that logically build from the parent project. Examples described include proposing additional aims that extend the original research direction and/or adding new methods that significantly strengthen the ability to analyze macromolecular interactions in vivo.
Is this mechanism intended for small add-ons or major expansions?
It was positioned as a targeted expansion: the award ceiling was $80,000, suggesting relatively focused additions rather than large-scale, multi-million-dollar expansions.
Can applicants request additional budget for the competitive revision?
Yes. The FOA explicitly allowed applicants to request an increased budget for the revision, recognizing that some advanced approaches can be expensive to add within an existing award budget.
What is the maximum amount allowed (award ceiling) for an individual revision?
The award ceiling listed for the initiative was $80,000.
What was the estimated total funding available for this initiative?
The estimated total funding listed was $3.2 million.
Was the FOA designed to help modestly funded laboratories?
Yes. A stated priority was enabling modestly funded laboratories to access approaches and research objectives that might otherwise be out of reach, lowering barriers for technically demanding, cell-relevant interaction studies.
Are collaborations required to apply?
No. Collaboration was optional. The expanded work could be done entirely within the parent laboratory if the needed expertise and infrastructure were already available.
Are collaborations allowed, including subcontracts?
Yes. The FOA permitted and supported collaborative arrangements, including subcontracts, when another investigator could provide complementary skills, instrumentation, or experimental systems.
How is the revision expected to relate to the existing (parent) grant?
The revision is expected to remain anchored to the original funded project and its scientific foundation, while expanding scope and/or technical reach in a way that builds logically from the parent award.
What general kinds of techniques or capabilities did NIGMS want to enable?
The FOA emphasized improving the field's ability to observe, measure, and interpret macromolecular interactions while preserving biological context. The description mentions examples such as advanced live-cell imaging and specialized biophysical measurements, as well as other resource-intensive techniques.
Does this funding opportunity require cost sharing or matching funds?
No. The opportunity did not require cost sharing or matching.
What is the assistance listing / CFDA number associated with this opportunity?
The opportunity is identified under CFDA 93.859, Biomedical Research and Research Training.
What NIH category does this opportunity fall under?
It is described as a discretionary grant opportunity in the NIH health research category.
When was the announcement posted?
The announcement was posted on January 27, 2012.
What was the closing date for applications?
The original and current closing date listed was October 18, 2012.
Is this FOA still active?
No. The announcement was archived on November 18, 2012.
What types of organizations were eligible to apply?
Eligibility was broad and included domestic and non-domestic organizations. Examples listed include federal, state, local, and tribal governments; public and private institutions of higher education; nonprofits (with and without 501(c)(3) status); for-profit organizations (including small businesses); independent school districts; and public housing authorities/Indian housing authorities.
Were certain institution types explicitly included (e.g., HBCUs, Hispanic-serving institutions, TCCUs)?
Yes. The eligibility language explicitly included institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), and faith-based or community-based organizations.
Could organizations in U.S. territories or regional organizations apply?
Yes. The eligibility language explicitly included U.S. territories or possessions and regional organizations.
Are foreign institutions eligible to apply?
Yes. Foreign institutions were eligible to apply. In addition, non-U.S. components of U.S. organizations were eligible, and foreign components were allowed consistent with NIH policy.
Does the FOA prioritize geography or the scientific focus?
Based on the description, the scientific focus was emphasized as the central consideration, with broad eligibility that included both U.S. and non-U.S. organizations.
What is the practical purpose of using this mechanism instead of applying for a brand-new grant?
As described, the mechanism was intended to strengthen ongoing NIGMS-funded research by allowing active R01/R37 projects to add new scientific dimensions and technical capabilities without having to wait for an entirely new grant cycle to pursue the next logical step in the research.
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