Opportunity Information: Apply for RFA MH 13 022
Apply for RFA MH 13 022
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Competitive Revision Applications for Research on Neural Processes Underlying Sex Differences Related to Risk and Resilience for Mental Illness (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
- This funding opportunity was created on Dec 13, 2011 and posted on Dec 13, 2011.
- Applicants must submit their applications by Mar 13, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,700,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) City or township governments For profit organizations other than small businesses Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public housing authorities/Indian housing authorities Private institutions of higher education State governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled Competitive Revision Applications for Research on Neural Processes Underlying Sex Differences Related to Risk and Resilience for Mental Illness (P50) (Funding Opportunity Number RFA-MH-13-022) is a discretionary NIH grant announcement led by the National Institute of Mental Health (NIMH) in partnership with the NIH Office of Research on Women's Health (ORWH). It was designed to fund competitive revision applications to existing P50 center grants, meaning it supported additional, expanded, or redirected work within already-funded P50 research centers rather than brand-new standalone projects. The core aim was to push basic and translational neuroscience forward by requiring applicants to explicitly test well-justified hypotheses about the neural mechanisms that drive sex differences relevant to mental health, with the expectation that findings would clarify why males and females can differ in vulnerability, symptom patterns, course, and recovery across mental disorders.
Scientifically, the FOA focused on the neurobiology of sex differences tied to both risk and resilience for mental illness. Applicants were expected to frame research questions around how sex-related factors influence brain development, neural circuitry, neuroendocrine and immune signaling, genetics and epigenetics, or other biological processes that could plausibly explain differences in mental health outcomes. A central requirement was that the proposed revision work needed to be hypothesis-driven and mechanistically oriented, not simply descriptive comparisons of males versus females. The application needed to make a strong case that the added or revised aims would substantially advance understanding of etiology and/or underlying pathophysiology of mental disorders in both sexes, meaning the work should help explain origins and biological underpinnings of illness rather than only documenting differences.
In practical terms, because this was a competitive revision mechanism, the opportunity was aimed at investigators and institutions with an active, eligible P50 award who could demonstrate that the new sex-differences-focused component was scientifically compelling, feasible, and well integrated with the parent center's structure and resources. The intent was to leverage existing infrastructure, cohorts, technologies, and collaborative cores typical of P50 centers to accelerate rigorous studies on sex differences in neural processes, ideally improving the field's ability to interpret mixed findings, refine models of disease mechanisms, and strengthen the translational pipeline toward better prevention and intervention strategies tailored to males and females.
The announcement fell under the Health funding activity category and the CFDA program number 93.242 (Mental Health Research Grants). It did not require cost sharing or matching. NIH posted and created the announcement on December 13, 2011, with an original and final closing date of March 13, 2012, and it was archived on April 13, 2012. The estimated total funding amount was $3,700,000, indicating NIH anticipated supporting a limited number of high-impact revisions across eligible P50 centers rather than a large portfolio of small projects.
Eligibility was broad across organization types, reflecting NIH norms, and included public and private institutions of higher education, public or state-controlled universities, nonprofits with or without 501(c)(3) status, small businesses, for-profit organizations (other than small businesses), and a range of governmental entities (state, county, city/township, special district, and certain housing authorities). The FOA also explicitly included institutions serving specific populations, such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities. Importantly, non-U.S. entities were eligible to apply, non-U.S. components of U.S. organizations were allowed, and foreign components were permitted as defined by the NIH Grants Policy Statement, which opened the door for international collaboration and data collection when scientifically justified.
For applicants or institutions needing the official details, NIH provided the full announcement online (http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-13-022.html). Administrative support contacts were also provided through the NIH Office of Extramural Research (OER) webmaster for access or linking issues. Overall, the opportunity was a targeted push to improve the rigor and depth of neuroscience research on sex differences in mental health by embedding mechanistic, hypothesis-driven aims into existing NIMH-supported P50 research centers, with the broader goal of sharpening understanding of mental illness biology across males and females and ultimately informing more precise prevention and treatment approaches.
Frequently Asked Questions (FAQs)
What is the official title and funding opportunity number for this grant?
The opportunity is titled Competitive Revision Applications for Research on Neural Processes Underlying Sex Differences Related to Risk and Resilience for Mental Illness (P50). The Funding Opportunity Number (FOA) is RFA-MH-13-022.
Which agency and NIH institutes were responsible for this announcement?
This is an NIH discretionary grant announcement led by the National Institute of Mental Health (NIMH) in partnership with the NIH Office of Research on Women's Health (ORWH).
What type of application did this FOA request?
This FOA was specifically for competitive revision applications to existing P50 center grants. It was intended to support additional, expanded, or redirected work within already-funded P50 research centers, rather than brand-new standalone projects.
What is the main scientific purpose of this opportunity?
The core goal was to advance basic and translational neuroscience by requiring applicants to explicitly test well-justified hypotheses about neural mechanisms driving sex differences that matter for mental health. The expectation was that results would help clarify why males and females can differ in vulnerability, symptom patterns, course, and recovery across mental disorders.
What topics or biological mechanisms were emphasized?
The FOA focused on the neurobiology of sex differences related to both risk and resilience for mental illness. Proposed work was expected to be framed around sex-related influences on areas such as:
- Brain development
- Neural circuitry
- Neuroendocrine signaling
- Immune signaling
- Genetics and epigenetics
- Other biological processes plausibly explaining differences in mental health outcomes
Did the FOA require hypothesis-driven and mechanistic research?
Yes. A central requirement was that the revision work be hypothesis-driven and mechanistically oriented. The FOA emphasized that the work should not be limited to descriptive comparisons of males versus females.
What kind of impact did the proposed revision aims need to show?
The application needed to make a strong case that the added or revised aims would substantially advance understanding of etiology and/or underlying pathophysiology of mental disorders in both sexes. In other words, the work should help explain origins and biological underpinnings of illness rather than only documenting observed differences.
Who was this funding opportunity intended for?
Because it used a competitive revision mechanism, it was aimed at investigators and institutions with an active, eligible P50 award who could demonstrate that the new sex-differences-focused component was scientifically compelling, feasible, and well integrated with the parent center's structure and resources.
How was the existing P50 center infrastructure expected to be used?
The intent was to leverage the existing infrastructure typical of P50 centers, such as established cohorts, technologies, and collaborative cores, to accelerate rigorous studies on sex differences in neural processes.
What was the broader expected benefit for the mental health field?
The FOA described a targeted push to improve the rigor and depth of neuroscience research on sex differences in mental health. By embedding mechanistic, hypothesis-driven aims into existing NIMH-supported P50 centers, the work was expected to help the field interpret mixed findings, refine models of disease mechanisms, and strengthen the translational pipeline toward better prevention and intervention strategies tailored to males and females.
What is the funding activity category and CFDA program number?
The funding activity category was Health. The CFDA program number listed was 93.242 (Mental Health Research Grants).
Was cost sharing or matching required?
No. The announcement stated that cost sharing or matching was not required.
When was the FOA posted and what were the due dates?
NIH posted and created the announcement on December 13, 2011. The original and final closing date was March 13, 2012.
Is this funding opportunity still open?
No. The opportunity was archived on April 13, 2012, and the final closing date was March 13, 2012.
What was the estimated total funding amount?
The estimated total funding amount was $3,700,000. This suggested NIH anticipated supporting a limited number of higher-impact competitive revisions across eligible P50 centers.
What types of organizations were eligible to apply?
Eligibility was broad and included a wide range of organization types, consistent with NIH norms, including:
- Public and private institutions of higher education
- Public or state-controlled universities
- Nonprofits with or without 501(c)(3) status
- Small businesses
- For-profit organizations (other than small businesses)
- Governmental entities (state, county, city/township, special district)
- Certain housing authorities
Were institutions serving specific populations explicitly included?
Yes. The FOA explicitly included institutions such as:
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Alaska Native and Native Hawaiian-serving institutions
- Tribally controlled colleges and universities
Were foreign (non-U.S.) organizations or components eligible?
Yes. The FOA stated that non-U.S. entities were eligible to apply. It also allowed non-U.S. components of U.S. organizations and permitted foreign components as defined by the NIH Grants Policy Statement, supporting international collaboration or data collection when scientifically justified.
Where can applicants find the official FOA text?
The full announcement was made available online at:
http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-13-022.html
Who was listed for administrative support related to access or linking issues?
Administrative support contacts were provided through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
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