Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional) | Apply Online

Opportunity Summary:

The Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional) funding opportunity (PAR-19-374) is a National Institutes of Health (NIH) cooperative agreement designed to support large, ambitious, and tightly coordinated research efforts that address a single overarching question or theme in aging. The core idea is to fund projects that are too complex to be handled well by a single stand-alone study, meaning the application is expected to propose multiple interdependent components (often several research projects and shared cores) that work together in a deliberately integrated way. The goal is not just to run several related studies side-by-side, but to create a program where each component informs and strengthens the others and where the combined whole is greater than the sum of its parts. Because the FOA is labeled “Clinical Trial Optional,” applicants may propose studies that include clinical trials, but they are not required to do so; the mechanism can support either clinical trial or non-clinical trial designs, as long as the overall research program remains focused on important questions relevant to aging.

The U19 is issued as a cooperative agreement rather than a standard grant, which signals that NIH anticipates an active partnership role during the life of the award. In practice, this typically means there is substantial NIH programmatic involvement in areas like milestones, coordination expectations, governance, progress monitoring, and sometimes harmonization across sites or components. This structure is particularly suited to multidisciplinary, multi-lab, or multi-institutional teams that need formal coordination to manage shared resources, common protocols, integrated datasets, or linked aims that depend on each other’s outputs.

The opportunity is aimed at projects that bring together investigators from multiple disciplines, either within a single institution or through a consortium of institutions. The emphasis on integration implies applicants should be prepared to describe how the different scientific pieces connect: how data and methods will be shared, how findings from one component will guide another, how the program will be managed, and how the collective effort will answer the central aging-related question more effectively than separate awards could. Typical multi-component U19 structures in NIH contexts often include administrative coordination and shared resource cores (for example, data management, biostatistics, recruitment, biospecimen handling, imaging, or other specialized platforms), though the exact configuration depends on the scientific needs of the proposed program.

Eligibility for applicants is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants listed for this FOA include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofit organizations (both with and without 501(c)(3) IRS status, other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. The FOA also explicitly highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; regional organizations; eligible federal agencies; Indian/Native American Tribal Governments other than federally recognized; and U.S. territories or possessions. This breadth is consistent with the multidisciplinary and often community- or population-engaged nature of aging research, where strong partnerships and diverse institutional settings can be critical.

At the same time, the FOA places clear limits on foreign participation at the applicant and component levels. Non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are not eligible to apply either. However, “foreign components” as defined by the NIH Grants Policy Statement are allowed, meaning a U.S. applicant may include certain international elements when they meet NIH’s definition and justification requirements (for example, specific activities or collaborations abroad that are necessary for the science), even though the primary applicant organization must remain U.S.-based and the structure cannot be a non-domestic applicant or a non-domestic component of a U.S. organization.

From an administrative standpoint, the opportunity is categorized as discretionary funding and uses the cooperative agreement funding instrument. It falls under the health activity category and is associated with CFDA number 93.866. The sponsoring agency is NIH. The opportunity record indicates an original closing date of 2022-09-25 and a creation date of 2019-09-13. The listing does not provide an award ceiling amount or the expected number of awards in the provided source data, so those details would normally need to be confirmed in the full FOA text or related NIH budget guidance for the specific receipt date.

Overall, this FOA is best suited for research teams that already have a strong central aging research question and can justify why answering it requires an integrated, multi-component structure with coordinated leadership, shared infrastructure, and tightly linked aims. The most competitive concepts under a U19 mechanism typically show clear synergy among components, rigorous coordination and governance plans, and a compelling argument that the cooperative, program-like design is essential to deliver meaningful advances in aging research.

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