Opportunity Information: Apply for PAR 16 143

  • The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Complex Integrated Multi-Component Projects in Aging Research (U19)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866,.
  • This funding opportunity was created on Mar 22, 2016 and posted on Mar 22, 2016.
  • Applicants must submit their applications by Sep 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:

Complex Integrated Multi-Component Projects in Aging Research (U19) (Funding Opportunity Number PAR-16-143) is a National Institutes of Health cooperative agreement opportunity (U19 mechanism) under HHS-NIH (CFDA 93.866) that supports large, complex, and highly coordinated research programs focused on important questions in aging. The core idea is to fund projects that are bigger than a single standard research grant, bringing together multiple interdependent research components that are intentionally designed to work as one integrated effort rather than as loosely related subprojects. Applications are expected to center on a unifying scientific theme or overarching research question directly relevant to aging research, with each component contributing a distinct but connected piece to the overall program goals.

Because the funding instrument is a cooperative agreement, the program is structured around substantial scientific and/or programmatic involvement by NIH staff compared with a typical investigator-initiated research project grant. In practice, this generally means applicants should anticipate active coordination with NIH program leadership during the life of the award, including shared expectations around milestones, integration across components, and overall project management. The opportunity is aimed at multidisciplinary teams and explicitly anticipates that these projects may be carried out either within a single institution or through a consortium of institutions, reflecting the reality that many aging-related research problems require a range of expertise, data sources, methods, and infrastructure that rarely sit in one lab.

Eligibility is broad and includes many types of domestic organizations and governments. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and additional entities as allowed under the announcement’s supplemental eligibility language. This breadth is consistent with the program’s emphasis on complex, collaborative structures, where academic, nonprofit, clinical, governmental, and private-sector partners may all play meaningful roles in producing integrated outcomes.

The opportunity was posted on March 22, 2016, with an original and current closing date listed as September 7, 2019. While the record does not specify an award ceiling or expected number of awards, the U19 mechanism typically implies a sizable, multi-component budget appropriate for coordinating several linked projects and any required shared resources, administration, or core functions needed to keep the overall program tightly integrated. Overall, this FOA is designed for applicants who can articulate a cohesive, high-impact aging research agenda, demonstrate genuine integration across multiple components, and assemble the leadership and governance structures needed to execute a coordinated, multi-investigator effort under a cooperative agreement framework.

Frequently Asked Questions (FAQs)

What is the funding opportunity called?

The opportunity is titled Complex Integrated Multi-Component Projects in Aging Research (U19).

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number is PAR-16-143.

Which federal agency is offering this opportunity?

This is a National Institutes of Health (NIH) opportunity under HHS-NIH.

What is the award mechanism for this opportunity?

The mechanism is a U19 cooperative agreement, intended for large, complex, highly coordinated research programs with multiple integrated components.

What does "cooperative agreement" mean in practice for applicants?

Because this is a cooperative agreement, NIH staff are expected to have substantial scientific and/or programmatic involvement compared with a typical investigator-initiated research grant. Applicants should plan for active coordination with NIH program leadership during the award period, including shared expectations around milestones, integration across components, and overall project management.

What is the purpose of this U19 opportunity?

The purpose is to support large, complex, and highly coordinated research programs that address important questions in aging research, using multiple interdependent components designed to operate as a single integrated effort.

What kind of projects is this opportunity designed to fund?

It is designed to fund projects that are bigger than a single standard research grant and that combine multiple interdependent research components intentionally designed to work together, rather than functioning as loosely related subprojects.

Do applications need a central theme?

Yes. Applications are expected to be organized around a unifying scientific theme or an overarching research question that is directly relevant to aging research, with each component providing a distinct but connected contribution to the overall program goals.

Are multidisciplinary teams expected or required?

The opportunity is aimed at multidisciplinary teams and reflects the expectation that many aging research problems require diverse expertise, data sources, methods, and infrastructure.

Can the project be conducted at a single institution, or does it need to be a consortium?

Projects may be carried out within a single institution or through a consortium of institutions. The announcement explicitly anticipates either structure.

What types of organizations are eligible to apply?

Eligibility is broad and includes many domestic organizations and governments. Eligible applicants include:

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and state-controlled institutions of higher education
  • Private institutions of higher education
  • Federally recognized Native American tribal governments
  • Other tribal organizations
  • Public housing authorities/Indian housing authorities
  • Nonprofit organizations with 501(c)(3) status (other than institutions of higher education)
  • Nonprofit organizations without 501(c)(3) status (other than institutions of higher education)
  • For-profit organizations (other than small businesses)
  • Small businesses
  • Additional entities as allowed under the announcement's supplemental eligibility language

Does the opportunity allow partnerships across sectors (academic, nonprofit, government, private sector)?

Yes. The broad eligibility aligns with the program's emphasis on complex collaborative structures where academic, nonprofit, clinical, governmental, and private-sector partners may all play meaningful roles in producing integrated outcomes.

What is the CFDA number associated with this opportunity?

The CFDA listing provided is 93.866.

When was this funding opportunity posted?

The opportunity was posted on March 22, 2016.

What is the closing date for the opportunity?

The record lists an original and current closing date of September 7, 2019.

Is the award ceiling specified?

No. The record does not specify an award ceiling.

Is the expected number of awards specified?

No. The record does not specify the expected number of awards.

What budget scope should applicants anticipate based on the U19 structure?

While specific budget limits are not provided, the U19 mechanism typically implies a sizable, multi-component budget appropriate for coordinating several linked projects and supporting any shared resources, administration, or core functions needed to keep the overall program tightly integrated.

What are reviewers or NIH likely to look for in a strong application (based on the description provided)?

Based on the description, a strong application would clearly articulate a cohesive, high-impact aging research agenda, demonstrate genuine integration across multiple components, and present leadership and governance structures capable of managing a coordinated, multi-investigator effort within a cooperative agreement framework.

How should the different research components relate to each other?

Each component should contribute a distinct piece of the work while remaining connected to the unifying theme or overarching question. The intent is for components to be interdependent and designed to function as one integrated program.

What kind of ongoing management expectations are implied?

The description implies that applicants should plan for deliberate integration across components, defined milestones, and active project management with NIH involvement throughout the life of the award.

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