Opportunity Information: Apply for PA 11 133

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Complex Technologies and Therapeutics Development for Mental Health Research and Practice" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
  • This funding opportunity was created on Feb 25, 2011 and posted on Feb 25, 2011.
  • Applicants must submit their applications by Jan 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Small businesses.
Apply for PA 11 133

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Opportunity Summary:

The funding opportunity titled "Complex Technologies and Therapeutics Development for Mental Health Research and Practice" (Funding Opportunity Number PA-11-133) is a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) grant initiative run through the National Institute of Mental Health (NIMH). Its core purpose is to help eligible small businesses design, build, and move forward with advanced technologies and therapeutic development efforts that directly support NIMH's broader mission: improving understanding, diagnosis, treatment, and real-world delivery of care for mental disorders. In practical terms, this opportunity is meant to push forward tools and products that could strengthen the full pipeline of mental health research and practice, from early neuroscience discovery through to clinical use and dissemination.

A defining feature of this announcement is its emphasis on "complex" technologies and therapeutics. The FOA recognizes that some high-impact mental health innovations cannot be responsibly developed under the standard SBIR funding limits or timeframes because they may require longer development cycles, more costly engineering or validation work, or multi-stage testing and iteration. As a result, the FOA encourages proposals that need expanded budgets and longer project periods compared to typical SBIR guidelines, specifically to accommodate the realities of building sophisticated, real-world-ready solutions in mental health.

The scope of supported work is broad but clearly anchored in mental health outcomes and NIMH priorities. Projects may target basic neuroscience research that is relevant to mental disorders (for example, tools that enable measurement, modeling, or experimental manipulation of brain systems implicated in psychiatric conditions). They may also focus on translational and clinical research, including development of platforms, devices, software, diagnostics, or therapeutic approaches that can be tested and refined for clinical relevance. Another explicit area is clinical diagnosis or treatment of mental disorders, which can include technologies that improve assessment accuracy, personalize care, monitor symptoms or treatment response, or deliver interventions more effectively. The FOA also calls out dissemination of evidence-based mental health care, signaling interest in innovations that improve implementation and uptake of proven interventions in real settings, such as clinics, community programs, schools, or other service environments.

Administratively, this is a discretionary grant program under the health activity category and is tied to CFDA number 93.242 (Mental Health Research Grants). The only eligible applicants listed are small businesses, consistent with SBIR program rules. There is no cost sharing or matching requirement, which means applicants are not required to provide a specified portion of project costs from non-federal sources as a condition of award. The opportunity was posted and created on February 25, 2011, with an original and final closing date of January 7, 2014, and it was archived on February 7, 2014, indicating it is no longer active for new submissions under that specific announcement.

For applicants or readers seeking the full official announcement details, NIH provided an additional information link to the FOA page hosted on the NIH grants site. For access issues or technical problems opening the announcement or linking to it, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

Frequently Asked Questions (FAQs)

What is the official title and funding opportunity number for this grant?

The opportunity is titled "Complex Technologies and Therapeutics Development for Mental Health Research and Practice" and the Funding Opportunity Number (FOA) is PA-11-133.

Which agency and institute run this funding opportunity?

This is a National Institutes of Health (NIH) Small Business Innovation Research (SBIR) initiative run through the National Institute of Mental Health (NIMH).

What is the main purpose of this SBIR opportunity?

Its purpose is to help eligible small businesses design, build, and advance complex technologies and therapeutic development efforts that support NIMH's mission to improve understanding, diagnosis, treatment, and real-world delivery of care for mental disorders.

What does the FOA mean by "complex" technologies and therapeutics?

The FOA emphasizes innovations that may not fit within standard SBIR limits or timelines because they can require longer development cycles, higher-cost engineering or validation work, or multi-stage testing and iteration. This announcement encourages proposals that need expanded budgets and longer project periods compared to typical SBIR guidelines to realistically support sophisticated development work.

Who is eligible to apply?

The only eligible applicants listed are small businesses, consistent with SBIR program rules.

Is cost sharing or matching required?

No. There is no cost sharing or matching requirement under this opportunity.

What kinds of projects are within scope?

The scope is broad but anchored in mental health outcomes and NIMH priorities. Supported work may include advanced technologies and therapeutic development efforts that strengthen the mental health research and practice pipeline, from early discovery through clinical use and dissemination.

Does the FOA support basic neuroscience research-related tools?

Yes. Projects may target basic neuroscience research relevant to mental disorders, including tools that enable measurement, modeling, or experimental manipulation of brain systems implicated in psychiatric conditions.

Does the FOA support translational and clinical research development?

Yes. The FOA includes translational and clinical research, such as development of platforms, devices, software, diagnostics, or therapeutic approaches that can be tested and refined for clinical relevance.

Are clinical diagnosis and treatment technologies included?

Yes. The FOA explicitly includes clinical diagnosis or treatment of mental disorders, including technologies to improve assessment accuracy, personalize care, monitor symptoms or treatment response, or deliver interventions more effectively.

Is dissemination or implementation of evidence-based care part of the scope?

Yes. The FOA calls out dissemination of evidence-based mental health care, indicating interest in innovations that improve implementation and uptake of proven interventions in real-world settings such as clinics, community programs, schools, or other service environments.

What stage of the research-to-practice pipeline does this opportunity aim to support?

It is intended to support the full pipeline, spanning early neuroscience discovery through to clinical use and dissemination in real-world practice.

What is the CFDA number associated with this opportunity?

The opportunity is tied to CFDA number 93.242, listed as Mental Health Research Grants.

What type of grant program is this described as administratively?

It is described as a discretionary grant program under the health activity category.

When was this funding opportunity posted and created?

It was posted and created on February 25, 2011.

What were the closing dates for submissions?

The original closing date and the final closing date listed are January 7, 2014.

Is this FOA still active?

No. The opportunity was archived on February 7, 2014, indicating it is no longer active for new submissions under that specific announcement.

Where can applicants find the full official announcement?

NIH provided an additional information link to the FOA page hosted on the NIH grants site (the NIH grants website).

Who should be contacted for technical issues accessing the FOA page?

For access issues or technical problems opening or linking to the announcement, the listed contact is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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