Opportunity Information: Apply for RFA AA 09 002
Apply for RFA AA 09 002
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Comprehensive Alcohol Research Center on HIV/AIDS (P60)" and is now available to receive applicants.
- This funding opportunity was created on Dec 3, 2008 and posted on Dec 3, 2008.
- Applicants must submit their applications by May 1, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Eligible applicants include: For profit organizations other than small businesses State governments Public housing authorities/Indian housing authorities City or township governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments County governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Small businesses Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Comprehensive Alcohol Research Center on HIV/AIDS (P60) funding opportunity (RFA AA 09 002) is a National Institutes of Health grant competition led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It supports the creation or continuation of a dedicated research center that brings together multiple disciplines to study how alcohol use intersects with HIV/AIDS. The core idea is to fund a center-level program that is cross-cutting and tightly integrated, meaning the projects are expected to fit together under a shared theme, reinforce each other scientifically, and produce outcomes that are stronger than what separate, stand-alone studies would generate. NIAAA also intends for the funded center to function as a national resource, so the work should have broad value for the larger research and public health community, not just the applicant institution.
The purpose of the FOA is to advance basic research on alcohol and HIV/AIDS in ways that can realistically be translated into interventions that reduce HIV infection and transmission. In other words, the science is not meant to stop at describing associations; it is meant to build foundational knowledge that can be converted into prevention strategies, tools, or approaches that work in real-world settings where alcohol use contributes to risk. The announcement aligns with the FY2009 Trans-NIH Plan for HIV-Related Research, signaling that the center should fit into national priorities for HIV research and help push forward coordinated federal goals.
NIAAA states two top scientific priorities. First, it places the highest emphasis on research that develops and tests biomedical prevention technologies that use basic understanding of HIV infection to design intervention strategies that prevent HIV spread between individuals and within communities, specifically in the context of alcohol use. This priority points toward prevention approaches that are biomedical in nature (as opposed to purely behavioral), and it emphasizes both individual-level and community-level transmission dynamics, with alcohol use treated as a key contextual factor that can alter risk, adherence, decision-making, exposure patterns, and biological susceptibility.
Second, NIAAA strongly prioritizes research that builds knowledge about interactions between alcohol and newer agents or drug regimens used to prevent and treat HIV-related conditions, especially comorbidities and complications linked to long-term HIV disease and antiretroviral therapy. The announcement explicitly highlights malignancies, liver disease, cardiovascular disease, metabolic disorders, and other long-term complications. The emphasis on alcohol-drug and alcohol-disease interactions reflects a real clinical and public health challenge: as HIV becomes more of a chronic condition for many people on antiretroviral therapy, long-term health outcomes are shaped by multiple interacting factors, including substance use, medication effects, and chronic inflammation or organ-specific vulnerabilities. Research under this priority would be expected to clarify mechanisms of harm or protection, identify risks tied to specific regimens or conditions, and inform safer, more effective prevention and treatment strategies for people who drink alcohol.
From an administrative and eligibility standpoint, this is a discretionary grant opportunity using the NIH center grant mechanism (P60), under the health funding activity category, with no cost-sharing or matching requirement. The FOA was posted on December 3, 2008, with an application closing date of May 1, 2009 (archived June 1, 2009). The estimated total funding level listed is $2,000,000. Eligible applicants are broad and include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations other than small businesses as well as small businesses, and a wide range of government entities (state, county, city/township, special district). Eligibility also explicitly includes groups and institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, federally recognized and other tribal governments, U.S. territories or possessions, federal agencies, and even non-U.S. (foreign) organizations and regional organizations, indicating an intent to encourage participation from many settings and populations.
Practically speaking, an applicant responding to this FOA would be expected to propose a cohesive center program organized around alcohol and HIV/AIDS, showing clear synergy across projects and disciplines (for example, combining virology or immunology with pharmacology, clinical research, epidemiology, implementation science, or community-engaged approaches). The proposed center should be designed to generate knowledge and tools that can move from bench to bedside to community, with particular attention to how alcohol use affects HIV prevention, transmission, treatment outcomes, and long-term complications. For full program requirements and application instructions, the FOA directs applicants to the NIH posting at http://grants.nih.gov/grants/guide/rfa files/RFA AA 09 002.html, and it provides NIH Office of Extramural Research webmaster contact information for access or linking issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
What is the Comprehensive Alcohol Research Center on HIV/AIDS (P60) funding opportunity?
It is a National Institutes of Health (NIH) grant competition (RFA AA 09 002) led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to support the creation or continuation of a dedicated research center focused on how alcohol use intersects with HIV/AIDS.
Which agency is leading this grant opportunity?
The opportunity is led by NIAAA, which is part of NIH.
What grant mechanism is used for this opportunity?
The funding uses the NIH center grant mechanism P60, intended to support a center-level, integrated research program.
What is the overall purpose of this FOA?
The purpose is to advance basic research on alcohol and HIV/AIDS in ways that can realistically be translated into interventions that reduce HIV infection and transmission. The focus is not limited to describing associations; it is meant to build knowledge that can be converted into prevention strategies, tools, or approaches that work in real-world settings where alcohol use contributes to risk.
What makes this a "center" program rather than a set of separate projects?
The FOA emphasizes a cross-cutting and tightly integrated program. The projects are expected to fit together under a shared theme, reinforce one another scientifically, and produce outcomes stronger than what separate, stand-alone studies would generate.
Does NIAAA expect the funded center to serve only the applicant institution?
No. NIAAA intends for the funded center to function as a national resource, meaning the work should have broad value for the larger research and public health community beyond the applicant institution.
What scientific areas does NIAAA prioritize most highly?
NIAAA lists two top scientific priorities: (1) research that develops and tests biomedical prevention technologies to prevent HIV spread in the context of alcohol use, and (2) research on interactions between alcohol and newer agents or drug regimens used to prevent and treat HIV-related conditions, especially comorbidities and long-term complications.
What is meant by "biomedical prevention technologies" in this FOA?
The FOA emphasizes prevention approaches that use a basic understanding of HIV infection to design intervention strategies that prevent HIV spread between individuals and within communities, specifically considering alcohol use as an important contextual factor. The announcement contrasts this emphasis with approaches that are purely behavioral.
Does the FOA focus on HIV transmission at the individual level, the community level, or both?
Both. The highest-priority biomedical prevention research is framed around preventing HIV spread between individuals and within communities, with alcohol use treated as a key factor that can influence risk and transmission dynamics.
How is alcohol use expected to be treated within the research theme?
Alcohol use is treated as a key contextual factor that can alter risk, adherence, decision-making, exposure patterns, and biological susceptibility relevant to HIV infection and transmission, as well as influence treatment outcomes and long-term complications.
What is the second major scientific priority focused on?
The second priority is research that builds knowledge about interactions between alcohol and newer agents or drug regimens used to prevent and treat HIV-related conditions, particularly comorbidities and complications linked to long-term HIV disease and antiretroviral therapy.
Which HIV-related comorbidities and long-term complications are explicitly highlighted?
The FOA explicitly highlights malignancies, liver disease, cardiovascular disease, metabolic disorders, and other long-term complications.
Why are alcohol-drug and alcohol-disease interactions emphasized in this FOA?
The FOA frames this as a clinical and public health challenge because, as HIV becomes more of a chronic condition for many people on antiretroviral therapy, long-term outcomes are shaped by interacting factors such as substance use, medication effects, and chronic or organ-specific vulnerabilities.
What kinds of results are expected from research on alcohol interactions with HIV therapies and complications?
Based on the FOA description, studies under this priority are expected to clarify mechanisms of harm or protection, identify risks tied to specific regimens or conditions, and inform safer, more effective prevention and treatment strategies for people who drink alcohol.
What types of disciplines or approaches can be combined in a proposed center?
The FOA indicates the center should bring together multiple disciplines and gives examples such as combining virology or immunology with pharmacology, clinical research, epidemiology, implementation science, or community-engaged approaches.
Is this FOA aligned with broader federal HIV research priorities?
Yes. The announcement aligns with the FY2009 Trans-NIH Plan for HIV-Related Research, indicating the center should fit into national priorities and help advance coordinated federal goals.
Is cost-sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
What is the estimated total funding level listed for this opportunity?
The estimated total funding level listed is $2,000,000.
When was the FOA posted and when did applications close?
The FOA was posted on December 3, 2008. The application closing date was May 1, 2009, and the opportunity was archived on June 1, 2009.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), and many government entities (state, county, city/township, and special district).
Are specific institution types and community organizations explicitly included as eligible?
Yes. The FOA explicitly includes HBCUs, Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, tribal governments (federally recognized and other), U.S. territories or possessions, federal agencies, and non-U.S. (foreign) organizations and regional organizations.
Can non-U.S. organizations apply?
Yes. The FOA explicitly includes non-U.S. (foreign) organizations and regional organizations as eligible applicants.
What is the expected structure of an application under this FOA?
An applicant is expected to propose a cohesive center program organized around alcohol and HIV/AIDS, demonstrating clear synergy across projects and disciplines, and designing the center to generate knowledge and tools that can move from bench to bedside to community.
What should applicants emphasize about how projects relate to one another?
The FOA stresses that projects should share a theme, reinforce each other scientifically, and be integrated in a way that produces stronger outcomes than separate studies would produce.
Where can applicants find the full program requirements and application instructions?
The FOA directs applicants to the NIH posting at http://grants.nih.gov/grants/guide/rfa_files/RFA-AA-09-002.html.
Who should be contacted for access or linking issues related to the NIH posting?
The NIH Office of Extramural Research webmaster contact listed is FBOWebmaster@OD.NIH.GOV.
What is the official identifier for this funding opportunity?
The opportunity is identified as RFA AA 09 002 and is titled "The Comprehensive Alcohol Research Center on HIV/AIDS (P60)."
What category of funding activity does this fall under?
It is listed under the health funding activity category.
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