Opportunity Information: Apply for PA 07 424

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Computational Tools for Research in Neuroscience, Behavioral Science and Mental Health SBIR R43/R44" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
  • This funding opportunity was created on Jan 26, 2009 and posted on Jul 27, 2007.
  • Applicants must submit their applications by Jan 7, 2011 Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Small businesses Others (see text field entitled Additional Information on Eligibility for clarification).
  • Foreign institutions are not eligible to apply.
Apply for PA 07 424

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Opportunity Summary:

The NIH funding opportunity PA 07 424, titled "Computational Tools for Research in Neuroscience, Behavioral Science and Mental Health SBIR R43/R44," is a Small Business Innovation Research (SBIR) grant program aimed at helping small businesses create new computational products that can be used in neuroscience, behavioral science, and mental health. The central focus is on developing and validating tools and resources that are not just research prototypes, but realistically commercializable technologies that researchers and clinicians can adopt. In practical terms, the NIH is looking for software, platforms, methods, or other computational resources that improve how mental health and brain-behavior research is conducted, how data are analyzed or managed, or how mental health providers and researchers apply evidence-based practices.

A second major emphasis of the announcement is on digital approaches that use interactive learning methods to share educational content related to mental health. This includes tools designed to teach or disseminate information about behavioral health interventions and assessment tools. The interactive learning angle signals interest in modern, user-centered digital training or education products, such as adaptive learning modules, simulations, or other interactive systems that can help clinicians, trainees, researchers, or potentially broader audiences learn validated mental health-related content more effectively than static materials.

This opportunity uses the SBIR R43/R44 mechanisms, which support Phase I, Phase II, and Fast Track applications. Phase I is generally intended to establish feasibility and technical merit, while Phase II supports more advanced development and validation work that moves the technology closer to a deployable product. The Fast Track option is designed for projects that can move directly from Phase I into Phase II with a streamlined review and transition plan. The announcement also notes it runs in parallel with an STTR companion FOA (PA 07 423) that has the same scientific scope but uses the STTR R41/R42 mechanisms, which are structured around a formal small business and research institution collaboration.

In terms of funding levels and project periods, applicants may request up to $250,000 in total costs per year for Phase I, with a project duration of up to 2 years. For Phase II, budgets may be up to $450,000 in total costs per year for up to 3 years. For Phase II Competing Renewals, budgets may be up to $800,000 in total costs per year for up to 3 years, reflecting support for later-stage efforts when there is a strong case for additional development, validation, or expansion toward broader adoption and commercialization. As with many federal grant programs, awards depend on the availability of funds and whether enough high-quality, competitive applications are submitted.

Eligibility is centered on small business concerns, consistent with SBIR rules. The opportunity explicitly states that foreign institutions are not eligible to apply. The program does not require cost sharing or matching funds, which is typical for SBIR awards and can reduce barriers for early-stage companies pursuing R and D. The sponsoring agency is the National Institutes of Health, and the activity aligns with CFDA 93.242 (Mental Health Research Grants), reinforcing that the program is rooted in advancing research and tools that can ultimately strengthen mental health science and practice.

Administratively, this is a discretionary grant opportunity with multiple receipt dates (rather than a single one-time deadline), and the original posting date is July 27, 2007, with later record updates reflected in the listing. The archived closing timeline in the provided source indicates the final listed receipt window ended in early 2011, meaning the specific announcement as written is historical, though NIH often reissues or updates similar SBIR topics over time. For applicants trying to pursue this kind of funding today, the practical takeaway is the scope and intent: NIH interest in commercially viable computational and digital learning tools that can be validated and put to work in neuroscience and mental health research, assessment, intervention support, and training.

FAQs: NIH SBIR PA 07-424 - Computational Tools for Research in Neuroscience, Behavioral Science and Mental Health (R43/R44)

What is the PA 07-424 funding opportunity?

PA 07-424 is an NIH Small Business Innovation Research (SBIR) funding opportunity titled "Computational Tools for Research in Neuroscience, Behavioral Science and Mental Health SBIR R43/R44." It supports small businesses developing computational products for neuroscience, behavioral science, and mental health research and practice.

What is the main goal of this SBIR program?

The program aims to help small businesses develop and validate computational tools and resources that go beyond research prototypes and are realistically commercializable, meaning they can be adopted by researchers and clinicians in real-world settings.

What kinds of projects does NIH want to fund under this announcement?

Projects may include software, platforms, methods, or other computational resources that improve how brain-behavior and mental health research is conducted, how data are analyzed or managed, or how evidence-based practices are applied by researchers and mental health providers.

Does this opportunity emphasize commercialization?

Yes. A central theme is developing technologies that are not just demonstrations or prototypes, but are feasible to commercialize and practical for adoption by researchers and clinicians.

Is digital education or training within scope?

Yes. A second major emphasis is on digital approaches that use interactive learning methods to disseminate educational content related to mental health, including tools that teach behavioral health interventions and assessment tools.

What does "interactive learning methods" mean in this context?

It refers to modern, user-centered digital training or education products that can be more effective than static materials, such as adaptive learning modules, simulations, or other interactive systems for teaching validated mental health-related content.

Who are the intended users of the tools developed under PA 07-424?

The intended users include researchers and clinicians, and for interactive learning tools may also include clinicians, trainees, researchers, or potentially broader audiences seeking validated mental health-related educational content.

Which grant mechanisms are used for this opportunity?

This opportunity uses the SBIR R43/R44 mechanisms and supports Phase I, Phase II, and Fast Track applications.

What is SBIR Phase I intended to support?

Phase I is generally intended to establish feasibility and technical merit for the proposed technology or product.

What is SBIR Phase II intended to support?

Phase II supports more advanced development and validation work to move the technology closer to a deployable product.

What is the SBIR Fast Track option?

Fast Track is designed for projects that can transition directly from Phase I to Phase II using a streamlined review and transition plan.

Is there a related STTR opportunity?

Yes. The announcement notes an STTR companion FOA (PA 07-423) with the same scientific scope, using the STTR R41/R42 mechanisms, which are structured around a formal collaboration between a small business and a research institution.

How much funding is available for Phase I?

Applicants may request up to $250,000 in total costs per year for Phase I, for a project duration of up to 2 years.

How much funding is available for Phase II?

Budgets for Phase II may be up to $450,000 in total costs per year for up to 3 years.

Is Phase II Competing Renewal funding mentioned, and how much is allowed?

Yes. Phase II Competing Renewals may be up to $800,000 in total costs per year for up to 3 years, reflecting support for later-stage development, validation, or expansion toward broader adoption and commercialization.

Are awards guaranteed if an application is submitted?

No. Awards depend on the availability of funds and whether enough high-quality, competitive applications are submitted.

Who is eligible to apply?

Eligibility is centered on small business concerns, consistent with SBIR rules.

Are foreign institutions eligible to apply?

No. The opportunity explicitly states that foreign institutions are not eligible to apply.

Is cost sharing or matching required?

No. The program does not require cost sharing or matching funds, which is typical for SBIR awards.

Which federal agency sponsors this opportunity?

The sponsoring agency is the National Institutes of Health (NIH).

What CFDA program is this associated with?

The activity aligns with CFDA 93.242 (Mental Health Research Grants).

Is this a discretionary grant?

Yes. It is identified as a discretionary grant opportunity.

Does PA 07-424 have multiple receipt dates?

Yes. The opportunity is described as having multiple receipt dates rather than a single one-time deadline.

When was this funding opportunity originally posted?

The original posting date is July 27, 2007, with later record updates reflected in the listing.

Is this announcement still open based on the provided information?

Based on the provided source description, the archived closing timeline indicates the final listed receipt window ended in early 2011, meaning the specific announcement as written is historical.

If PA 07-424 is historical, what is the practical takeaway for applicants?

The practical takeaway is NIH interest in commercially viable computational tools and interactive digital learning products that can be validated and applied in neuroscience and mental health research, assessment, intervention support, and training, noting that NIH may reissue or update similar SBIR topics over time.

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Previous opportunity: Computational Tools for Research in Neuroscience, Behavioral Science and Mental Health STTR R41/R42

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