Opportunity Information: Apply for RFA AI 10 004
Apply for RFA AI 10 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Consortia for AIDS Vaccine Research in Nonhuman Primates (P01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy, Immunology and Transplantation Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Apr 1, 2010 and posted on Apr 1, 2010.
- Applicants must submit their applications by Nov 3, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Eligible applicants include: County governments Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education City or township governments Public housing authorities/Indian housing authorities Small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Independent school districts Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The grant opportunity "Consortia for AIDS Vaccine Research in Nonhuman Primates (P01)" (Funding Opportunity Number RFA-AI-10-004) is a National Institutes of Health program run through the National Institute of Allergy and Infectious Diseases (NIAID). Its central aim is to build a coordinated, team-based research effort focused on what happens immediately after exposure to simian immunodeficiency virus (SIV) in nonhuman primates, especially at mucosal surfaces where infection often begins. The scientific emphasis is on understanding the earliest viral and host events that drive whether infection takes hold, then using that knowledge to identify vaccines and vaccine-driven immune responses capable of stopping infection at the start, preventing systemic spread, or at least meaningfully reducing the harmful (pathogenic) consequences of SIV infection. In practical terms, the FOA is looking for applicants who can connect mechanistic studies of early mucosal transmission and immune defense with vaccine concepts that can be tested in relevant nonhuman primate models, producing results that inform HIV vaccine development more broadly.
This opportunity uses the NIH Program Project Grant (P01) mechanism, which is designed for large, integrated projects made up of multiple interrelated research components under a unified scientific theme. The P01 structure is meant to support consortia-style work: multidisciplinary teams that can bring together expertise such as mucosal immunology, virology, vaccinology, animal model science, and immunologic assay development, and then coordinate those capabilities to answer linked questions that would be difficult to tackle through a single-project grant. The announcement also points out that a separate but related FOA with similar overall scientific scope exists under an R01 mechanism (RFA-AI-10-001). Applicants are explicitly encouraged to apply to one or the other, but not both, signaling that NIAID wanted proposals aligned with the scale and collaborative design of the selected mechanism rather than duplicate submissions across mechanisms.
In terms of funding, NIAID planned to commit about $5.0 million in total costs in fiscal year 2011 for this program, with an expectation of funding one or two awards. The language also notes that awards depend on the availability of funds, which is standard for federal grant announcements but important for planning since it means the final number of awards and total dollars could shift based on appropriations and competing priorities.
The FOA is categorized as a discretionary grant in the health area and is associated with CFDA numbers 93.855 (Allergy, Immunology and Transplantation Research) and 93.856 (Microbiology and Infectious Diseases Research). There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of the award.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), and a range of governmental entities such as state, county, city or township governments, special district governments, and independent school districts. The FOA also includes tribal governments and tribal organizations, public housing authorities/Indian housing authorities, U.S. territories or possessions, and a variety of institution types and community-based entities, including historically Black colleges and universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations. It also allows non-U.S. (foreign) organizations and regional organizations, and notes that eligible federal agencies may apply as well.
Key administrative dates show the FOA was posted on April 1, 2010, with an original and current closing date of November 3, 2010, and an archive date of December 4, 2010. For applicants or readers seeking the full original announcement details, the FOA provided an NIH link to the full text and included contact information through the NIH Office of Extramural Research (OER) webmaster for access or technical linking problems.
FAQs: Consortia for AIDS Vaccine Research in Nonhuman Primates (P01) (RFA-AI-10-004)
What is the official title and funding opportunity number for this grant?
The opportunity is titled "Consortia for AIDS Vaccine Research in Nonhuman Primates (P01)" and the Funding Opportunity Number is RFA-AI-10-004.
Which agency and institute run this program?
This is a National Institutes of Health (NIH) program run through the National Institute of Allergy and Infectious Diseases (NIAID).
What is the central scientific aim of this FOA?
The central aim is to build a coordinated, team-based research effort focused on what happens immediately after exposure to simian immunodeficiency virus (SIV) in nonhuman primates, with particular attention to mucosal surfaces where infection often begins.
What does the FOA emphasize about early infection events?
The FOA emphasizes understanding the earliest viral and host events that determine whether infection takes hold after exposure, especially at mucosal sites.
How does vaccine research fit into the goals of this opportunity?
The FOA seeks to use insights from early transmission and early immune defense to identify vaccines and vaccine-driven immune responses capable of stopping infection at the start, preventing systemic spread, or meaningfully reducing the pathogenic consequences of SIV infection.
What kinds of studies is NIAID looking for under this FOA?
Applicants are expected to connect mechanistic studies of early mucosal transmission and immune defense with vaccine concepts that can be tested in relevant nonhuman primate models, producing results intended to inform HIV vaccine development more broadly.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH Program Project Grant (P01) mechanism.
What does the P01 mechanism imply about project structure?
The P01 mechanism is designed for large, integrated projects made up of multiple interrelated research components under a unified scientific theme. It is intended to support consortia-style, multidisciplinary teamwork and coordinated capabilities.
What kinds of expertise does the FOA anticipate within a consortium?
The FOA points to multidisciplinary teams that can bring together capabilities such as mucosal immunology, virology, vaccinology, animal model science, and immunologic assay development, coordinated to answer linked questions that would be difficult to tackle through a single-project grant.
Is there a related funding opportunity under a different NIH mechanism?
Yes. The announcement notes a separate but related FOA with similar overall scientific scope under an R01 mechanism: RFA-AI-10-001.
Can an applicant submit to both the P01 and the related R01 FOA?
No. Applicants are explicitly encouraged to apply to one or the other, but not both.
How much funding did NIAID plan to commit for this program?
NIAID planned to commit about $5.0 million in total costs in fiscal year 2011 for this program.
How many awards were expected?
The FOA indicated an expectation of funding one or two awards.
Is the number of awards guaranteed?
No. The FOA notes that awards depend on the availability of funds, meaning final award numbers and total dollars could change based on appropriations and priorities.
What type of grant is this categorized as?
The FOA is categorized as a discretionary grant in the health area.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.855 (Allergy, Immunology and Transplantation Research) and 93.856 (Microbiology and Infectious Diseases Research).
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-domestic organizations, including public and private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations (including small businesses); and a wide range of governmental entities.
Are state and local government entities eligible?
Yes. The FOA includes state, county, city or township governments; special district governments; and independent school districts.
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes tribal governments and tribal organizations among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed as eligible applicants.
Are minority-serving institutions and similar entities included in eligibility?
Yes. The FOA explicitly includes institution types and community-based entities such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA allows non-U.S. (foreign) organizations and regional organizations to apply.
Can federal agencies apply?
Yes. The FOA notes that eligible federal agencies may apply.
When was this FOA posted?
The FOA was posted on April 1, 2010.
What was the closing date for applications?
The original and current closing date listed is November 3, 2010.
When was the FOA archived?
The archive date is December 4, 2010.
Where can someone find the full original announcement text?
The FOA provided an NIH link to the full text of the announcement.
Who should be contacted for access issues or technical problems with the FOA link?
The FOA included contact information through the NIH Office of Extramural Research (OER) webmaster for access or technical linking problems.
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