Opportunity Information: Apply for RFA GM 10 007
Apply for RFA GM 10 007
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Consortia for High Throughput Enabled Structural Biology Partnerships (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Aug 12, 2009 and posted on Jul 24, 2009.
- Applicants must submit their applications by Oct 28, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Private institutions of higher education Native American tribal governments (Federally recognized) Special district governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Public housing authorities/Indian housing authorities State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH National Institute of General Medical Sciences (NIGMS) funding opportunity RFA-GM-10-007, titled "Consortia for High Throughput Enabled Structural Biology Partnerships (U01)," was designed to support collaborative projects that tackle major, clearly defined biological questions by generating large numbers of protein structures. The central idea is to pair two kinds of expertise: (1) investigators focused on an important biological problem of broad significance, and (2) investigators or centers that can deliver high throughput protein structure determination through the NIGMS PSIBiology network. Rather than funding isolated single-protein projects, this program emphasizes biological problems where solving many related structures is essential to making real progress, such as mapping a pathway, understanding a protein family, or interpreting how structural variation drives function across a system.
A key requirement is that the proposed protein targets must fit well with high throughput structural biology approaches, meaning they should be reasonably amenable to rapid expression, purification, and structure determination workflows. At the same time, the FOA also leaves room for targets that are not straightforward if they are compelling enough to push method development forward. In other words, the program is not only about producing structures efficiently; it is also about using challenging or strategically chosen targets to motivate new technologies, improved pipelines, or better ways to scale structural analysis.
The award mechanism is a U01 cooperative agreement, which signals that NIH expects to be actively involved in coordinating and guiding the overall effort. This is not a hands-off grant where each group operates independently. Instead, the cooperative agreement structure is used because the broader PSIBiology initiative involves many moving parts, and NIH staff participation is needed to facilitate coordination across the network, align goals, and ensure that the different components work together effectively. Investigators funded under this FOA would not just run their own projects; they would also participate in the governance and coordination of the broader network.
Specifically, the principal investigators of funded awards become members of the PSIBiology Network Steering Committee. That role comes with an expectation of joint planning and shared management with other network investigators and NIH staff. The steering committee participation reflects the program's consortium model: the funded partnerships are meant to be integrated pieces of a larger national effort in high throughput enabled structural biology, rather than standalone research islands.
In terms of funding scale, NIGMS indicated an expected total of $5 million to $25 million in awards under this announcement, with an anticipated 5 to 10 awards. This wide range suggests flexibility depending on the strength and scope of applications and the final configuration of supported partnerships. There is no cost sharing or matching requirement noted in the opportunity information.
Eligibility is broad and includes a range of domestic organizational types across nonprofit, academic, government, and certain for-profit entities. Eligible applicants listed include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, state and local governments (including county and city/township governments), independent school districts, special district governments, public housing authorities/Indian housing authorities, tribal governments and tribal organizations (including entities beyond federally recognized tribal governments), small businesses, and for-profit organizations other than small businesses. The FOA also explicitly includes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions, indicating an intent to keep the applicant pool inclusive across institutional types.
Administrative details from the posting show it was a discretionary funding opportunity from NIH in the health research area (CFDA 93.859, Biomedical Research and Research Training). It was posted July 24, 2009, with an original closing date of October 9, 2009, later reflected with a current closing date of October 28, 2009, and an archive date of November 28, 2009. The full announcement was hosted through the NIH grants guide at the provided link in the source data.
Overall, this FOA can be understood as a network-building, problem-driven structural biology program: applicants were expected to bring a substantial biological question where many structures are needed, leverage or partner with high throughput structure determination capabilities in the PSIBiology network, and commit to active coordination through a steering committee under a cooperative agreement model with meaningful NIH involvement.
Frequently Asked Questions (FAQs)
What is the funding opportunity?
This opportunity is the NIH National Institute of General Medical Sciences (NIGMS) Funding Opportunity Announcement (FOA) RFA-GM-10-007 titled "Consortia for High Throughput Enabled Structural Biology Partnerships (U01)." It supports collaborative partnerships that address major biological questions by generating large numbers of protein structures.
What is the main goal of this FOA?
The goal is to fund consortia that can make real progress on a clearly defined biological problem of broad significance by solving many related protein structures. The program is designed for problem-driven structural biology where a collection of structures (not a single structure) is essential to answer the question.
What kind of projects does the program emphasize?
The program emphasizes biological problems where many structures are needed to move the field forward, such as mapping a biological pathway, understanding a protein family at scale, or interpreting how structural variation across a system relates to function.
Is this program meant to fund single-protein structural projects?
No. A central emphasis is on projects where solving many related structures is essential, rather than isolated single-protein efforts.
What is meant by "high throughput enabled structural biology" in this context?
In this FOA, high throughput enabled structural biology refers to approaches and workflows designed to rapidly express, purify, and determine structures for many protein targets, leveraging capabilities associated with the NIGMS PSIBiology network.
What is the partnership model this FOA is trying to create?
The FOA is built around pairing two complementary kinds of expertise: (1) investigators focused on an important biological problem, and (2) investigators or centers that can deliver high throughput protein structure determination through the NIGMS PSIBiology network.
Do proposed protein targets need to be suitable for high throughput pipelines?
Yes. A key requirement is that proposed targets should generally be amenable to rapid expression, purification, and structure determination workflows that fit high throughput structural biology approaches.
Are challenging or difficult protein targets allowed?
Yes. While targets should fit high throughput approaches, the FOA leaves room for targets that are not straightforward if they are compelling enough to drive method development, improved pipelines, new technologies, or better scaling of structural analysis.
What is the award mechanism?
The award mechanism is a U01 cooperative agreement.
What does a U01 cooperative agreement imply about NIH involvement?
A cooperative agreement indicates NIH expects to be actively involved in coordinating and guiding the overall effort. This is not intended to be a hands-off arrangement; NIH staff participation is part of facilitating coordination, aligning goals, and ensuring components of the broader PSIBiology initiative work together effectively.
Are awardees expected to operate as standalone projects?
No. The FOA is network-building and consortium-based. Funded partnerships are intended to function as integrated parts of a broader national effort (PSIBiology), rather than as independent, isolated projects.
What governance or coordination responsibilities are expected of funded investigators?
The principal investigators (PIs) of funded awards are expected to participate in the governance and coordination of the broader PSIBiology network.
What is the PSIBiology Network Steering Committee, and who participates?
The PSIBiology Network Steering Committee is a governance and coordination body for the network. Under this FOA, the PIs of funded awards become members of the Steering Committee.
What does Steering Committee membership require?
Steering Committee participation comes with expectations of joint planning and shared management with other network investigators and NIH staff, consistent with the consortium model.
How much funding did NIGMS expect to make available under this announcement?
NIGMS indicated an expected total of $5 million to $25 million in awards under this FOA.
How many awards were anticipated?
The FOA anticipated making approximately 5 to 10 awards.
Why is the expected total funding range so wide?
The stated range suggests flexibility depending on the strength and scope of applications and how the final set of supported partnerships is configured.
Is cost sharing or matching required?
No cost sharing or matching requirement is noted in the provided opportunity information.
Who is eligible to apply?
Eligibility is broad and includes many domestic organization types across academic, nonprofit, government, and certain for-profit entities, as reflected in the listed eligible applicant categories.
Are colleges and universities eligible?
Yes. Eligible applicants include public and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofits with and without 501(c)(3) status.
Are government entities eligible?
Yes. Eligible applicants include state governments, local governments (including county and city/township governments), special district governments, independent school districts, public housing authorities/Indian housing authorities, eligible federal agencies, and U.S. territories or possessions.
Are tribal governments and tribal organizations eligible?
Yes. Eligibility includes tribal governments and tribal organizations, including entities beyond federally recognized tribal governments.
Are businesses eligible to apply?
Yes. Eligible applicants include small businesses and for-profit organizations other than small businesses.
Does the FOA indicate inclusion of minority-serving or mission-focused institution types?
Yes. The listed eligible categories explicitly include groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and faith-based or community-based organizations, among others.
Which NIH institute issued this opportunity?
This FOA was issued by the NIH National Institute of General Medical Sciences (NIGMS).
What NIH program or network is referenced as the high throughput structural biology resource?
The FOA references the NIGMS PSIBiology network as the source of high throughput protein structure determination capabilities to be leveraged or partnered with.
What is the CFDA number and program area listed?
The posting identifies CFDA 93.859, described as Biomedical Research and Research Training, and characterizes the opportunity as in the health research area.
When was the opportunity posted?
The posting date listed is July 24, 2009.
What were the closing dates?
The posting shows an original closing date of October 9, 2009, and a later-reflected current closing date of October 28, 2009.
When was the opportunity archived?
The archive date listed is November 28, 2009.
Where was the full announcement hosted?
The full announcement was hosted through the NIH grants guide at the link provided in the source data.
How should someone describe this FOA in plain terms?
It is a network-building, problem-driven structural biology program designed to support partnerships that need many protein structures to answer an important biological question, while leveraging high throughput structure determination through PSIBiology and committing to coordinated governance under a U01 cooperative agreement with meaningful NIH involvement.
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