Consortium of Food Allergy Research (CoFAR) and CoFAR Statistical and Clinical Coordinating Center (CoFAR SACCC) (U19 and U01) | Apply Online

Opportunity Summary:

The Consortium of Food Allergy Research (CoFAR) and CoFAR Statistical and Clinical Coordinating Center (CoFAR SACCC) funding opportunity (RFA AI 09 039) is a National Institutes of Health (NIH) cooperative agreement announcement led by the National Institute of Allergy and Infectious Diseases (NIAID) in partnership with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). Its central aim is to continue and expand CoFAR as a coordinated clinical research consortium focused on IgE-mediated food allergy, including severe outcomes such as food allergy-associated anaphylaxis, and related conditions such as food allergy-associated eosinophilic gastrointestinal disease (EGID). The program is designed to bring multiple clinical research efforts into a shared structure so that studies can be conducted in a harmonized way, with common goals, shared resources, and coordinated oversight typical of NIH cooperative agreements.

The research goals are framed around three big needs in the field. First, the consortium is expected to develop immune-based intervention strategies that could prevent food allergy from developing in the first place or treat established disease, meaning proposals should be geared toward clinically relevant approaches that modify immune responses rather than only describing associations. Second, the program seeks to clarify the mechanisms that drive the natural histories of food allergy and related disorders, including how these conditions begin, progress, persist, or resolve over time; this emphasis supports longitudinal clinical research, careful phenotyping, and studies that connect clinical outcomes with underlying immunology. Third, CoFAR is tasked with defining genetic components of these disorders, signaling an expectation for collecting and analyzing genetic data where appropriate and linking genetic findings to clinical and mechanistic insights.

This announcement supports two complementary award types. For research sites and scientific projects, NIH uses the U19 mechanism for multi-project cooperative agreements (structured programs with multiple integrated projects under one umbrella) and the U01 mechanism for single-project cooperative agreements (one focused project). The consortium can therefore include both larger, multi-component programs and stand-alone projects, as long as they fit into the collaborative CoFAR model. Separately, the FOA funds one Statistical and Clinical Coordinating Center (SACCC) under a U01 mechanism. The SACCC is intended to serve as the operational backbone for the clinical research effort, typically providing functions such as clinical trial coordination, data management, statistical design and analysis, protocol support, quality assurance, harmonization across sites, and overall clinical research logistics that allow multiple projects to function like a unified consortium.

The total anticipated funding for fiscal year 2010 is $5.25 million in total costs. Of that, $3.65 million is reserved for one to three CoFAR research awards (a mix of U19 and/or U01), and $1.6 million is planned for a single CoFAR SACCC U01 award. Because these are cooperative agreements, NIH program staff generally play an active role alongside awardees in shaping consortium activities, facilitating coordination, and ensuring that projects align with consortium-wide priorities and standards.

In terms of eligibility, the opportunity is broadly open to a wide range of applicant organizations, reflecting NIH-wide eligibility norms for many RFAs. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government (state, county, city/township, special district), as well as independent school districts and public housing authorities/Indian housing authorities. The announcement also explicitly includes a number of institution types and communities under “other eligible applicants,” such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions, along with tribal governments and tribal organizations in specified categories. There is no cost sharing or matching requirement stated.

Key administrative details include the posting date of July 7, 2009, with an original and current closing date of November 10, 2009, and an archive date of December 11, 2009. The funding instrument type is a cooperative agreement, and the activity category is aligned with Food and Nutrition and Health. The program is associated with CFDA numbers 93.855 (Allergy, Immunology and Transplantation Research) and 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). Additional details and the full announcement were made available through the NIH Grants Guide at the link provided in the source text.

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