Opportunity Information: Apply for RFA DK 13 017
Apply for RFA DK 13 017
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Consortium on Modeling Autoimmune Interactions (CMAI) HIRN (UC4)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Sep 26, 2013 and posted on Sep 26, 2013.
- Applicants must submit their applications by Feb 27, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $9,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $600,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Private institutions of higher education Native American tribal governments (Federally recognized) City or township governments Small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments Special district governments County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH Funding Opportunity Announcement RFA-DK-13-017 supports the creation of a Consortium on Modeling Autoimmune Interactions (CMAI) as part of the Human Islet Research Network (HIRN). The overall purpose of CMAI is to accelerate progress in understanding human type 1 diabetes by building robust, coordinated systems that can measure, represent, and model the underlying biology of the disease, with a particular emphasis on autoimmune interactions that contribute to islet dysfunction and beta cell loss. As a founding consortium within HIRN, CMAI is intended to operate in a collaborative, networked environment where teams contribute complementary capabilities and share data, methods, and experimental resources to produce integrated models that better reflect human disease biology rather than relying solely on simplified or indirect systems.
The award mechanism is a UC4 cooperative agreement, meaning NIH expects substantial scientific and programmatic involvement beyond typical grant stewardship. In practice, this structure generally supports coordinated milestones, consortium-wide standards, shared governance, and active participation in cross-site working groups and data/resource sharing. The FOA sits within the NIH mission space of diabetes and related metabolic disease research (CFDA 93.847, Diabetes, Digestive, and Kidney Diseases Extramural Research) and is focused on consortium building and systems development to enable more predictive, human-relevant modeling approaches for type 1 diabetes.
Funding for the opportunity was estimated at $9,000,000 total, with an award ceiling of $600,000. There is no cost sharing or matching requirement. The FOA was posted on September 26, 2013, with an application closing date of February 27, 2014, and an archive date of March 30, 2014. Eligible applicants are broad and include a wide range of domestic and international organizations: public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); state, county, city/township, special district, and certain school district governments; tribal governments and tribal organizations; U.S. territories/possessions; and foreign organizations/foreign institutions. The eligibility list also explicitly includes a variety of minority-serving institutions (such as HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs) as well as faith-based and community-based organizations, and eligible federal agencies. Foreign components, as defined in NIH policy, are allowed, and non-U.S. components of U.S. organizations may participate.
In summary, this FOA sought to assemble a coordinated consortium capable of developing and applying rigorous measurement and modeling frameworks to capture key autoimmune and islet-related processes in human type 1 diabetes, leveraging the cooperative agreement structure to ensure strong integration with NIH priorities and close collaboration across the broader HIRN initiative. For the full announcement and application details, the FOA directs applicants to the NIH posting at http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-13-017.html and provides the NIH OER Webmaster contact for access or linking issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs): NIH RFA-DK-13-017 (CMAI within HIRN)
What is the funding opportunity RFA-DK-13-017 about?
RFA-DK-13-017 is an NIH Funding Opportunity Announcement that supports the creation of a Consortium on Modeling Autoimmune Interactions (CMAI) within the Human Islet Research Network (HIRN). The focus is on building coordinated systems to measure, represent, and model the biology of human type 1 diabetes, with a particular emphasis on autoimmune interactions that contribute to islet dysfunction and beta cell loss.
What is the main purpose of the CMAI consortium?
The overall purpose of CMAI is to accelerate progress in understanding human type 1 diabetes by developing robust, coordinated measurement and modeling frameworks that better reflect human disease biology, especially the autoimmune processes affecting islets and beta cells.
How does CMAI fit into the Human Islet Research Network (HIRN)?
CMAI is described as a founding consortium within HIRN. It is intended to operate in a collaborative, networked environment where teams contribute complementary capabilities and share data, methods, and experimental resources to produce integrated models that are more human-relevant than simplified or indirect systems.
What type of grant mechanism is used for this opportunity?
The award mechanism is a UC4 cooperative agreement. This means NIH expects substantial scientific and programmatic involvement beyond typical grant stewardship.
What does "substantial NIH involvement" typically mean under a UC4 cooperative agreement?
Based on the description provided, the cooperative agreement structure generally supports coordinated milestones, consortium-wide standards, shared governance, and active participation in cross-site working groups, along with data and resource sharing across participating teams.
What kinds of activities or outputs is this FOA aiming to support?
This FOA emphasizes consortium building and systems development to enable more predictive, human-relevant modeling approaches for type 1 diabetes. It highlights coordinated systems that can measure, represent, and model underlying disease biology, with a strong emphasis on autoimmune interactions and their role in islet dysfunction and beta cell loss.
What is the scientific focus area of the FOA?
The FOA is focused on understanding human type 1 diabetes through modeling and measurement systems, particularly the autoimmune interactions that contribute to islet dysfunction and beta cell loss.
Which NIH mission area or program category does this opportunity fall under?
The opportunity sits within NIH's diabetes and related metabolic disease research mission space and is listed under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
How much total funding was estimated for this opportunity?
The total funding for the opportunity was estimated at $9,000,000.
What is the award ceiling for an individual award?
The award ceiling is $600,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
When was the FOA posted, and what were the key dates?
The FOA was posted on September 26, 2013. The application closing date was February 27, 2014. The archive date was March 30, 2014.
Who is eligible to apply?
Eligible applicants are broad and include domestic and international organizations. The eligibility list includes: public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); various government entities (state, county, city/township, special district, and certain school district governments); tribal governments and tribal organizations; U.S. territories/possessions; foreign organizations/foreign institutions; faith-based and community-based organizations; and eligible federal agencies.
Are minority-serving institutions included as eligible applicants?
Yes. The eligibility list explicitly includes multiple categories of minority-serving institutions, including HBCUs, Hispanic-serving institutions, AANAPISIs, and TCCUs.
Are foreign organizations or international components allowed to participate?
Yes. Foreign organizations/foreign institutions are listed as eligible applicants. In addition, foreign components (as defined in NIH policy) are allowed, and non-U.S. components of U.S. organizations may participate.
Is this FOA more oriented toward individual projects or toward building a coordinated consortium?
Based on the description provided, it is oriented toward assembling and operating a coordinated consortium that develops and applies rigorous measurement and modeling frameworks, with strong integration and collaboration across the broader HIRN initiative.
Why does the FOA emphasize human-relevant models rather than simplified systems?
The FOA highlights a goal of producing integrated models that better reflect human disease biology, rather than relying solely on simplified or indirect systems. This emphasis is tied to improving the ability to represent and understand the underlying biology of human type 1 diabetes.
Where can applicants find the full FOA announcement and application details?
The FOA directs applicants to the NIH posting at: http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-13-017.html
Who should be contacted for access or linking issues related to the FOA?
The FOA provides the NIH OER Webmaster contact for access or linking issues: FBOWebmaster@OD.NIH.GOV
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