Opportunity Information: Apply for RFA FD 13 031
Apply for RFA FD 13 031
- The Food Drug Administration in the other (see text field entitled explanation of other category of funding activity for clarification) sector is offering a public funding opportunity titled "Cooperative Agreement to Support the North Carolina State University, Prestage Department of Poultry Science and the Piedmont Research Station (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.103 Food and Drug AdministrationResearch.
- This funding opportunity was created on Jun 21, 2013 and posted on Jun 21, 2013.
- Applicants must submit their applications by Jul 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $50,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Eligibility is limited to the North Carolina State University. The North Carolina State University, Prestage Department of Poultry Science utilizes the Piedmont Research Station Poultry Unit (Salisbury, North Carolina) to conduct large scale research projects with commercial broilers, layers, broiler breeders and commercial style egg incubation. The Piedmont Research Station Poultry Unit is a unique facility that has housing for over 15,000 commercial layers, 8,000 broiler breeders, and incubation capacity to hatch more than 52,000 eggs at one time utilizing both multi stage and single stage incubation. The Layer Performance Management Test for North America is annually conducted at the Piedmont Research Station, with studies in applied production practices and nutrition management. These facilities are able to evaluate the effects of a research project on a size and scale that mimics commercial poultry operations. The North Carolina State University, Prestage Department of Poultry Science utilizes their onsite feed mill, which is a research and educational feed mill that is designed and equipped to manufacture a variety of feed mix characteristics, formulations, and feed forms. It is currently used by FDA for training purposes associated with the safe feed safe food program, and is among the few research feed mills in the country that is associated with animal research facilities. The mill has all of the typical process equipment found in commercial feed mills, including an 8 ton/hr CPM hammer mill, 8 ton/hr RMS roller mill, micro bin batching system, a 500 lb horizontal ribbon mixer, a 2 ton double shaft ribbon mixer, a 1 ton/hr CPM pellet mill with counter flow cooler, a 10 ton/hr Bliss pellet mill with counter flow cooler, pellet screener, bagger, bulk ingredient bins, finished feed bins, and an automated computer controlled batch mixing and process operation. This feed mill is able to manufacture feed of various feed ingredient grind size in mash or pellet forms. While other academic institutions also have outstanding poultry and egg research programs, they do not have commercial style research facilities such as the Piedmont Research Station Poultry Unit, feed mill and resources to conduct large scale commercial size research projects. Moreover, the North Carolina State University, Prestage Department of Poultry Science and Piedmont Research Facility are within close geographic proximity for collaboration with the FDA Department of Immunobiology. This will allow FDAs investigational scientists to travel by automobile on key experimental dates to initiate research experiments and collect tissue and environmental samples. These samples will be transported within 24 hours back to the FDA Department of Immunobiology for microbiological testing and analysis.
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Opportunity Summary:
This FDA funding opportunity (RFA FD 13 031) set out a single-source cooperative agreement in FY2013 to North Carolina State Universitys Prestage Department of Poultry Science, specifically to support research activities at the Piedmont Research Station Poultry Unit in Salisbury, North Carolina. The underlying public health driver was the continued burden of Salmonella Enteritidis associated with shell eggs, highlighted by the roughly 1,939 reported salmonellosis cases in 2010 tied to SE contamination. In response, FDA positioned this work as part of a broader risk-management and prevention agenda aligned with the Center for Food Safety and Applied Nutritions 2013 strategic science and research plan, with the practical goal of reducing both vertical transmission (from hen to egg) and horizontal transmission (spread through the flock and environment) of SE and potentially other Salmonella serovars across egg and poultry production.
The project focus centered on studying Salmonella transmission pathways and testing interventions under conditions that closely resemble real commercial production rather than small laboratory setups. A key rationale in the announcement is that modern intensive genetic selection for high egg output may have unintentionally affected birds natural resistance to microbial contamination, making it more urgent to identify control strategies that can realistically work at scale. FDA intended this cooperative agreement to enable collaborative, applied research that could pinpoint the main routes by which Salmonella persists and spreads in egg operations and then evaluate practical measures to interrupt those routes before contaminated eggs reach consumers.
The partnership outlined four main purposes. First, it aimed to use a commercial-style research facility to model vertical and horizontal Salmonella transmission in ways that mirror what happens in the egg industry. Second, it planned to test whether changes in physical feed characteristics and housing conditions influence transmission, recognizing that factors like feed form or particle size and the physical environment birds live in can affect gut health, stress, exposure to fecal material, and ultimately pathogen shedding and spread. Third, it sought to assess how disinfection protocols already used commercially perform in reducing horizontal transmission, with special attention to differences between alternative housing and more traditional systems. Fourth, it aimed to compare how often different Salmonella serovars appear across multiple housing environments, specifically conventional cages, enriched cage systems, and free-range setups, since each system can differ in bird contact patterns, litter or manure handling, and environmental exposure that could change Salmonella ecology.
Eligibility was intentionally limited to NCSU, and the notice makes the case that this restriction was based on unique capabilities at the Piedmont Research Station Poultry Unit and associated infrastructure. The station was described as having housing for more than 15,000 commercial layers and 8,000 broiler breeders, along with incubation capacity exceeding 52,000 eggs at a time using both multistage and single-stage incubation. It also hosts the annual Layer Performance Management Test for North America and supports applied studies in production practices and nutrition management, which reinforces the stations role as a large-scale, industry-relevant research platform rather than a purely academic facility.
Another major asset highlighted was NCSUs onsite feed mill, presented as a rare research-and-education mill integrated with animal research facilities and equipped with commercial-type processing equipment. The announcement lists capabilities such as hammer and roller mills, micro-bin batching, ribbon mixers, pellet mills with counterflow coolers, screening and bagging systems, ingredient and finished-feed bins, and computerized batch control. This infrastructure matters for the grants scientific aims because it allows controlled manipulation of feed characteristics (such as grind size and mash versus pellet form) in a way that matches industry processes, making it possible to test how realistic feed changes might affect Salmonella transmission dynamics.
Because this was a cooperative agreement, FDAs role was expected to be more hands-on than in a typical grant, emphasizing collaboration and substantial federal involvement. The announcement specifically notes the geographic proximity of NCSU and the Piedmont facility to FDAs Department of Immunobiology, enabling FDA scientists to travel by automobile for key experimental dates, participate in initiating experiments, and collect tissue and environmental samples. It also emphasizes rapid sample transport (within 24 hours) back to FDA for microbiological testing and analysis, underscoring that the work was designed to integrate field-scale animal studies with FDA laboratory capacity for pathogen detection and characterization.
In administrative terms, the opportunity was posted June 21, 2013, with a closing date of July 15, 2013, and an archive date of August 14, 2013. The instrument type was a cooperative agreement, with one expected award and an estimated total funding amount of $50,000, which also served as the award ceiling. The CFDA program reference was 93.103 (Food and Drug Administration Research). There was no cost-sharing or matching requirement noted. The point of contact listed for access or grants management questions was Lisa Ko, Grants Management Specialist (lisa.ko@fda.hhs.gov).
FDA Cooperative Agreement RFA FD 13 031 - Frequently Asked Questions (FAQs)
1) What is this funding opportunity?
This is an FDA funding opportunity identified as RFA FD 13 031. It supported a single-source cooperative agreement in FY2013 to North Carolina State University (NCSU), specifically the Prestage Department of Poultry Science, to conduct research at the Piedmont Research Station Poultry Unit in Salisbury, North Carolina.
2) What public health problem was the opportunity designed to address?
The opportunity was driven by the continued burden of Salmonella Enteritidis (SE) associated with shell eggs. The notice highlights approximately 1,939 reported salmonellosis cases in 2010 tied to SE contamination as part of the motivation for this work.
3) What was the overall goal of the project?
The practical goal was to reduce Salmonella Enteritidis transmission in egg and poultry production, focusing on both vertical transmission (from hen to egg) and horizontal transmission (spread through the flock and environment). The work was also positioned as potentially relevant to other Salmonella serovars.
4) How does this project fit into FDA priorities?
The notice describes the work as part of a broader FDA risk-management and prevention agenda aligned with the Center for Food Safety and Applied Nutrition (CFSAN) 2013 strategic science and research plan.
5) What makes this project different from a typical laboratory study?
The project emphasized studying Salmonella transmission and testing interventions under conditions that closely resemble real commercial production, rather than small laboratory setups. The intent was to generate findings that are more directly applicable at industry scale.
6) Why did the announcement mention intensive genetic selection in poultry?
The announcement notes that modern intensive genetic selection for high egg output may have unintentionally affected birds' natural resistance to microbial contamination. This was presented as part of the rationale for urgently identifying control strategies that can work realistically at scale.
7) What were the four main purposes of the cooperative agreement?
The notice outlined four main purposes:
- Use a commercial-style research facility to model vertical and horizontal Salmonella transmission in ways that mirror egg-industry conditions.
- Test whether changes in physical feed characteristics and housing conditions influence transmission.
- Assess how commercially used disinfection protocols perform in reducing horizontal transmission, including differences between alternative housing and traditional systems.
- Compare how often different Salmonella serovars appear across conventional cages, enriched cage systems, and free-range setups.
8) What kinds of transmission did the research aim to study?
The research aimed to model both:
- Vertical transmission (from hen to egg)
- Horizontal transmission (spread through the flock and environment)
9) What factors related to feed were included in the project focus?
The opportunity aimed to test whether physical feed characteristics could influence Salmonella transmission. The notice specifically points to factors such as feed form and particle size (for example, mash versus pellet form and grind size) as variables that can be manipulated and evaluated.
10) What factors related to housing were included in the project focus?
The project included evaluating transmission and Salmonella occurrence across multiple housing environments, specifically conventional cages, enriched cage systems, and free-range setups. The notice also discusses how housing can affect bird contact patterns, litter or manure handling, and environmental exposure, which may influence Salmonella ecology.
11) What role did disinfection protocols play in the proposed work?
The agreement planned to assess how disinfection protocols already used commercially perform in reducing horizontal transmission, with particular attention to differences between alternative housing systems and traditional systems.
12) Was the opportunity open to multiple applicants?
No. Eligibility was intentionally limited to North Carolina State University (NCSU).
13) Why was eligibility restricted to NCSU?
The notice states that the restriction was based on unique capabilities and infrastructure at the Piedmont Research Station Poultry Unit and associated facilities, positioning it as a large-scale, industry-relevant research platform.
14) What research infrastructure at the Piedmont Research Station Poultry Unit was highlighted?
The notice highlights that the station had:
- Housing for more than 15,000 commercial layers
- Housing for 8,000 broiler breeders
- Incubation capacity exceeding 52,000 eggs at a time, using both multistage and single-stage incubation
15) What ongoing programs at the station were mentioned as evidence of its industry relevance?
The station was described as hosting the annual Layer Performance Management Test for North America and supporting applied studies in production practices and nutrition management.
16) Why was the onsite feed mill considered important to the research goals?
The onsite feed mill was presented as a rare research-and-education mill integrated with animal research facilities and equipped with commercial-type processing equipment. This matters because it allows controlled manipulation of feed characteristics using industry-like processes, supporting realistic testing of how feed changes might affect Salmonella transmission dynamics.
17) What specific feed mill capabilities were listed in the notice?
The announcement lists capabilities including:
- Hammer and roller mills
- Micro-bin batching
- Ribbon mixers
- Pellet mills with counterflow coolers
- Screening and bagging systems
- Ingredient and finished-feed bins
- Computerized batch control
18) What type of funding instrument was used?
The instrument type was a cooperative agreement.
19) What does it mean that this was a cooperative agreement in this specific opportunity?
The notice indicates that FDA was expected to have a more hands-on role than in a typical grant, emphasizing collaboration and substantial federal involvement. FDA scientists were expected to participate in key experimental dates, help initiate experiments, and collect tissue and environmental samples.
20) Why did geographic proximity matter for this cooperative agreement?
The notice emphasizes that NCSU and the Piedmont facility are geographically close to FDA's Department of Immunobiology. This proximity was described as enabling FDA scientists to travel by automobile for key experimental dates and to support rapid sample transport back to FDA.
21) How quickly were samples expected to be transported to FDA for testing?
The announcement underscores rapid sample transport within 24 hours back to FDA for microbiological testing and analysis.
22) How many awards were expected under this opportunity?
One award was expected.
23) What was the estimated total funding amount and the award ceiling?
The estimated total funding amount was $50,000, and this amount also served as the award ceiling.
24) Was cost-sharing or matching required?
No cost-sharing or matching requirement was noted in the opportunity description provided.
25) What was the CFDA program reference for this opportunity?
The CFDA program reference was 93.103 (Food and Drug Administration Research).
26) When was the opportunity posted and when did it close?
The opportunity was posted on June 21, 2013, and the closing date was July 15, 2013.
27) When was the opportunity archived?
The archive date was August 14, 2013.
28) Who was the listed point of contact for access or grants management questions?
The point of contact listed was Lisa Ko, Grants Management Specialist. Email: lisa.ko@fda.hhs.gov.
29) Where was the funded research intended to take place?
The research activities were specifically intended to be supported at the Piedmont Research Station Poultry Unit in Salisbury, North Carolina.
30) Which institution and department were identified as the recipient for this single-source award?
The recipient identified was North Carolina State University's Prestage Department of Poultry Science.
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