Opportunity Information: Apply for RFA AI 13 016
Apply for RFA AI 13 016
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Cooperative Centers on Human Immunology (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Mar 21, 2013 and posted on Mar 21, 2013.
- Applicants must submit their applications by Jul 29, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $20,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,750,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education City or township governments County governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts State governments For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Special district governments Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Cooperative Centers on Human Immunology (U19) funding opportunity (RFA-AI-13-016) is a National Institutes of Health program, led through NIAID, aimed at building and supporting research centers that can run coordinated, multidisciplinary studies on how the human immune system is activated, regulated, and shaped during infectious diseases and related interventions. The core scientific focus is on hypothesis-driven, mechanistic work in humans, rather than purely descriptive profiling. In practice, the program is trying to push the field toward explaining "how and why" human immune responses occur in real-world contexts like natural infection, vaccination, or the use of vaccine adjuvants that stimulate innate immune receptors. The centers supported under this opportunity are expected to generate insights that improve understanding of immune defense against infectious disease and help inform vaccine or immunomodulatory strategies.
A key feature of the opportunity is that it is not only paying for individual research projects but also for the centralized infrastructure needed to make complex human immunology studies feasible and efficient. That includes stable and flexible coordinating capacity that can support collaboration across disciplines (for example, clinical investigators, immunologists, microbiologists, systems biologists, and computational teams) and across multiple projects within a center. The emphasis on a cooperative agreement (U19) signals that the government anticipates substantial programmatic involvement and coordination, rather than a hands-off grant model, which is typical for large center-based efforts that require alignment on shared goals, common resources, and coordinated study execution.
Programmatically, this initiative started in fiscal year 2003 and the announcement describes it as being renewed for the second time through open competition, meaning new applicants are welcome and there is no requirement to have held prior awards under this program, or even prior NIAID/NIH funding, to apply. The announcement explicitly invites all qualified investigators, which is intended to keep the competition open and bring in strong new teams and ideas, not just renew existing groups.
From a funding standpoint, the opportunity lists an estimated total funding amount of $20,000,000, with an award ceiling of $1,750,000. There is no cost sharing or matching requirement stated. The mechanism is a discretionary cooperative agreement, and the activity categories fall under health, aligned with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). The posting date was March 21, 2013, and the application due date (closing date) was July 29, 2013, with the archive date listed as August 29, 2013.
Eligibility is broad and includes a wide range of U.S. and non-U.S. organizations. Eligible applicants include public and private institutions of higher education; nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits); various levels of government (city/township, county, state), independent school districts, special district governments, public housing authorities/Indian housing authorities, tribal organizations (including federally recognized tribal governments and other tribal entities), and for-profit organizations other than small businesses, as well as small businesses themselves. The opportunity also highlights eligibility for institutions serving specific communities, such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions, along with faith-based or community-based organizations and eligible federal agencies. Importantly, foreign participation is allowed: non-domestic (non-U.S.) organizations and foreign institutions may apply, non-domestic components of U.S. organizations are eligible, and foreign components are allowed as defined under the NIH Grants Policy Statement.
Overall, the grant is designed for teams that can combine strong human immunology science with the organizational capability to run a center: integrating multiple projects, building shared resources, coordinating across disciplines, and producing mechanistic insights into immune responses to infection and vaccination (including adjuvant-driven innate receptor targeting). The full announcement was hosted on the NIH Grants Guide website at http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-13-016.html, and the contact listed for access or linking issues is the NIH Office of Extramural Research Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is the Cooperative Centers on Human Immunology (U19) funding opportunity, RFA-AI-13-016.
Which agency and NIH institute lead this program?
This is a National Institutes of Health (NIH) program led through the National Institute of Allergy and Infectious Diseases (NIAID).
What is the main goal of the Cooperative Centers on Human Immunology (U19) program?
The program aims to build and support research centers that can run coordinated, multidisciplinary studies on how the human immune system is activated, regulated, and shaped during infectious diseases and related interventions.
What kind of science does this opportunity prioritize?
It prioritizes hypothesis-driven, mechanistic work in humans, rather than purely descriptive profiling. The intent is to push toward explaining how and why human immune responses occur in real-world contexts.
What settings or contexts are emphasized for studying immune responses?
The opportunity emphasizes real-world human contexts such as natural infection, vaccination, and the use of vaccine adjuvants that stimulate innate immune receptors.
What outcomes is the program trying to achieve?
The centers are expected to generate insights that improve understanding of immune defense against infectious disease and help inform vaccine or immunomodulatory strategies.
Does the funding support only individual research projects?
No. A key feature is that it supports both the research projects and the centralized infrastructure needed to make complex human immunology studies feasible and efficient.
What does "centralized infrastructure" mean in this opportunity?
Based on the description, it includes stable and flexible coordinating capacity to support collaboration across disciplines and across multiple projects within a center.
What kinds of disciplines are expected to collaborate within a center?
The opportunity highlights collaboration across disciplines such as clinical investigators, immunologists, microbiologists, systems biologists, and computational teams.
What does the "U19" mechanism indicate about how the award will be managed?
U19 is a cooperative agreement mechanism. The announcement states this signals substantial programmatic involvement and coordination by the government, rather than a hands-off grant model.
Why does this program use a cooperative agreement instead of a traditional grant?
The description frames it as typical for large, center-based efforts that require alignment on shared goals, common resources, and coordinated study execution, with anticipated programmatic involvement and coordination.
When did this initiative begin, according to the announcement?
The initiative is described as having started in fiscal year 2003.
Is this announcement only for existing awardees, or can new groups apply?
New applicants are welcome. The announcement describes the program as renewed through open competition and explicitly invites all qualified investigators.
Do applicants need to have held prior awards under this program to apply?
No. The announcement indicates there is no requirement to have held prior awards under this program.
Do applicants need prior NIAID or NIH funding to apply?
No. The announcement indicates there is no requirement to have had prior NIAID/NIH funding to apply.
What is the estimated total funding amount for this opportunity?
The opportunity lists an estimated total funding amount of $20,000,000.
What is the award ceiling per award?
The award ceiling is listed as $1,750,000.
Is cost sharing or matching required?
No cost sharing or matching requirement is stated in the information provided.
How is this opportunity categorized (activity categories / subject area)?
The activity categories fall under health, aligned with CFDA 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
What is the posting date for the opportunity?
The posting date is March 21, 2013.
What is the application due date (closing date)?
The application due date (closing date) is July 29, 2013.
What is the archive date?
The archive date is August 29, 2013.
What types of U.S. organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits); and various levels of government (city/township, county, state), among others described in the announcement.
Are for-profit organizations eligible?
Yes. The opportunity includes for-profit organizations other than small businesses, and also includes small businesses.
Are K-12 education-related entities mentioned as eligible applicants?
Yes. Independent school districts are listed among eligible applicants.
Are housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are listed among eligible applicants.
Are tribal organizations eligible?
Yes. Eligibility includes tribal organizations, including federally recognized tribal governments and other tribal entities.
Are minority-serving institutions specifically encouraged or included?
The opportunity highlights eligibility for institutions serving specific communities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI institutions.
Are faith-based or community-based organizations eligible?
Yes. The opportunity explicitly highlights faith-based or community-based organizations as eligible.
Are eligible federal agencies allowed to apply?
Yes. Eligible federal agencies are included in the eligibility description.
Is foreign participation allowed?
Yes. The announcement states that non-domestic (non-U.S.) organizations and foreign institutions may apply.
Can a U.S. organization include a non-U.S. (non-domestic) component and still be eligible?
Yes. Non-domestic components of U.S. organizations are stated as eligible.
Are foreign components allowed within an application?
Yes. Foreign components are allowed as defined under the NIH Grants Policy Statement.
What kind of organizational capability is this grant designed to support?
It is designed for teams that can combine strong human immunology science with the organizational capability to run a center, including integrating multiple projects, building shared resources, coordinating across disciplines, and producing mechanistic insights.
Where can applicants find the full announcement?
The full announcement was hosted on the NIH Grants Guide website at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-13-016.html
Who is listed as the contact for access or linking issues?
The contact listed for access or linking issues is the NIH Office of Extramural Research Webmaster at FBOWebmaster@OD.NIH.GOV.
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