Cooperative Ecosystem Studies Unit, Great Rivers CESU | Apply Online

Opportunity Summary:

The Cooperative Ecosystem Studies Unit, Great Rivers CESU funding opportunity (Funding Opportunity Number G15AS00092) is a US Geological Survey (USGS) discretionary research award intended to support a single CESU partner organization in carrying out science and technology research on the transgenerational effects of endocrine disrupting chemicals (EDCs) on fish. The award is issued as a cooperative agreement, meaning the work is expected to be conducted in close coordination with USGS, with substantial involvement by the agency during the project as compared to a more hands-off grant.

The central focus of the project is on how environmental contaminants that interfere with normal endocrine (hormonal) signaling can cause harms that extend beyond the directly exposed organisms. The opportunity highlights that chemical exposures do not only produce immediate or short-term effects in an organism, but can also contribute to health problems that appear in later generations that were never directly exposed to the original chemical stressor. In this context, the announcement uses the term "transgenerational phenotype" to describe an abnormal health outcome that arises in descendants because prior generations experienced chemical exposure. The description frames this as an emerging and important issue across many forms of life, noting that transgenerational outcomes have been observed in organisms as diverse as humans and plants.

The opportunity also emphasizes the likely role of epigenetic mechanisms in driving these long-lasting effects. Epigenetics generally refers to molecular changes that influence gene activity without changing the underlying DNA sequence, and these changes can sometimes be inherited. The announcement points to laboratory evidence in rats showing that a wide range of toxicants (including plastics, herbicides, fungicides, pesticides, dioxin, and hydrocarbons) can promote epigenetic transgenerational disease phenotypes detectable even three generations later. Against that backdrop, USGS is seeking research that helps fill a key knowledge gap: there are far fewer documented examples of similar transgenerational endocrine-disruption effects in fish and wildlife. The proposed work is therefore positioned as a way to extend what is known from mammalian lab systems into aquatic organisms, where endocrine disruptors are a common and persistent environmental concern.

From an administrative standpoint, the opportunity is tied to CFDA 15.808 (U.S. Geological Survey Research and Data Collection) and is limited to eligible applicants that are already partners in the Great Rivers Cooperative Ecosystem Studies Unit (CESU) Program. CESUs are formal partnerships designed to connect federal agencies with universities, nonprofits, and other research entities to deliver research, technical assistance, and education. Because eligibility is restricted to Great Rivers CESU partners, organizations outside that network would not be able to apply unless they participate through an eligible partner consistent with CESU rules.

In terms of funding and timing, USGS expected to make one award with an estimated total funding amount of $146,875. The notice states there is no cost sharing or matching requirement. Key dates listed in the announcement include a posted and created date of June 29, 2015, an original and current closing date of July 17, 2015, and an archive date of September 29, 2015. The award ceiling and floor are both shown as 0 in the source data, which typically indicates that the specific ceiling and floor were not entered into that field rather than implying no funding; the estimated total funding amount provides the practical funding expectation.

For applicants seeking the full announcement and application details, the posting directs users to Grants.gov via the additional information link (http://www.grants.gov/). A contact is provided for access issues or questions about the announcement: Faith Graves at 703-648-7356 and fgraves@usgs.gov.

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