Opportunity Information: Apply for RFA AI 11 034

  • The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Cooperative Study Group for Autoimmune Disease Prevention (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
  • This funding opportunity was created on Jun 17, 2011 and posted on Jun 17, 2011.
  • Applicants must submit their applications by Nov 8, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,600,000.00 to eligible and selected applicants.
  • Eligible applicants include: Private institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments For profit organizations other than small businesses Independent school districts Public housing authorities/Indian housing authorities County governments Special district governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:

The Cooperative Study Group for Autoimmune Disease Prevention (U01) is a National Institutes of Health (NIH) cooperative agreement funding opportunity issued by the National Institute of Allergy and Infectious Diseases (NIAID) together with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It invites applications from individual institutions or consortia that want to participate in a coordinated research network focused specifically on preventing human autoimmune diseases. In this announcement, "prevention" is defined in a very specific way: stopping an autoimmune disease process before it reaches clinical onset, using approaches other than broad, global immunosuppression. In practice, this pushes applicants toward targeted, mechanism-based prevention strategies, early-intervention designs, and biomarker-driven identification of at-risk individuals, rather than treatments that simply suppress the entire immune system.

The program is structured as a cooperative study group, meaning it is not a collection of isolated grants running independently. Instead, it is designed as a coordinated set of cooperative agreements with substantial collaboration and coordination across awardees, guided by a Steering Committee. This structure is meant to support shared decision-making on scientific priorities, study designs, common measures, and operational standards so that the group can run multi-site or harmonized prevention studies efficiently. A key feature is the inclusion of an Infrastructure and Opportunities Fund, which is intended to enable innovative, collaborative work that may not fit neatly into a single site award. This fund can support pilot efforts, feasibility testing, and new collaborative projects that emerge from the group’s activities, helping the network adapt to new scientific opportunities or promising leads.

Administratively, the funding instrument is a Cooperative Agreement (U01), reflecting an expectation of active partnership between NIH and funded investigators. The opportunity was posted and created on June 17, 2011, with an original and current closing date of November 8, 2011, and an archive date of December 9, 2011. The estimated total funding listed for the program is $2,600,000, and there is no cost sharing or matching requirement. The opportunity is associated with CFDA numbers 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research), reflecting the cross-cutting nature of autoimmune disease prevention across immune-mediated and metabolic/endocrine disease areas.

Eligibility is broad and includes many types of U.S. organizations and governments, such as public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations other than small businesses, and small businesses. It also includes various governmental entities, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Tribal eligibility is explicitly included through federally recognized Native American tribal governments as well as other tribal organizations, and the announcement also lists eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs). Faith-based or community-based organizations and eligible federal agencies are also included. Importantly, non-U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, and foreign components of U.S. organizations are allowed, signaling an openness to international collaboration where it strengthens the prevention research mission.

The official funding opportunity number is RFA AI 11 034, and the title is Cooperative Study Group for Autoimmune Disease Prevention (U01). The NIH is the issuing agency, and the full announcement is available through the NIH grants guide at http://grants.nih.gov/grants/guide/rfa files/RFA AI 11 034.html. For access or technical issues with the posting, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

FAQs: Cooperative Study Group for Autoimmune Disease Prevention (U01) - RFA AI 11 034

What is this grant opportunity?

This opportunity is the Cooperative Study Group for Autoimmune Disease Prevention (U01), a National Institutes of Health (NIH) cooperative agreement funding opportunity focused on coordinated research to prevent human autoimmune diseases.

Which NIH institutes are involved?

The opportunity is issued by the National Institute of Allergy and Infectious Diseases (NIAID) together with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

What does "autoimmune disease prevention" mean in this announcement?

In this announcement, "prevention" is defined specifically as stopping an autoimmune disease process before it reaches clinical onset. The approaches are expected to be something other than broad, global immunosuppression.

Are applications expected to use broad immunosuppression approaches?

No. The announcement explicitly defines prevention as approaches other than broad, global immunosuppression, which steers projects toward targeted, mechanism-based prevention strategies.

What types of study approaches does this opportunity emphasize?

Based on how prevention is defined, the opportunity pushes applicants toward targeted, mechanism-based prevention strategies, early-intervention designs, and biomarker-driven identification of at-risk individuals rather than whole-immune-system suppression.

What is the funding mechanism?

The funding instrument is a Cooperative Agreement (U01).

What does it mean that this is a U01 cooperative agreement?

A U01 cooperative agreement reflects an expectation of active partnership between NIH and the funded investigators, with substantial collaboration and coordination across awardees.

Is this program a set of independent grants?

No. It is structured as a cooperative study group and is designed as a coordinated set of cooperative agreements rather than isolated awards operating independently.

How will collaboration across awardees be organized?

The program is guided by a Steering Committee to support shared decision-making on scientific priorities, study designs, common measures, and operational standards so the group can conduct multi-site or harmonized prevention studies efficiently.

What is the Steering Committee expected to do?

Based on the announcement description, the Steering Committee is intended to guide coordination across awardees and support shared decisions around scientific priorities, study design, common measures, and operational standards.

What is the Infrastructure and Opportunities Fund?

The program includes an Infrastructure and Opportunities Fund intended to enable innovative, collaborative work that may not fit neatly into a single site award.

What kinds of activities can the Infrastructure and Opportunities Fund support?

The fund can support pilot efforts, feasibility testing, and new collaborative projects that emerge from the group’s activities, helping the network adapt to new scientific opportunities or promising leads.

Who can apply?

Applications are invited from individual institutions or consortia that want to participate in a coordinated research network focused on preventing human autoimmune diseases.

What types of organizations are eligible within the United States?

Eligibility includes a wide range of U.S. organizations and governments, such as public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations other than small businesses, and small businesses.

Are government entities eligible?

Yes. The announcement lists multiple governmental entities as eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.

Are tribal governments and tribal organizations eligible?

Yes. Eligibility explicitly includes federally recognized Native American tribal governments as well as other tribal organizations.

Are certain types of educational institutions explicitly included?

Yes. The eligibility list includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs).

Are faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations are explicitly listed as eligible.

Are eligible federal agencies allowed to apply?

Yes. Eligible federal agencies are included in the eligibility list.

Are non-U.S. organizations allowed to apply?

Yes. The announcement states that non-U.S. entities (foreign organizations) are allowed.

Are international or regional organizations allowed?

Regional organizations are listed as allowed, and the announcement signals openness to international collaboration where it strengthens the prevention research mission.

Are U.S. territories or possessions allowed to apply?

Yes. The eligibility section indicates that U.S. territories or possessions are allowed.

Are foreign components of U.S. organizations allowed?

Yes. The announcement states that foreign components of U.S. organizations are allowed.

What is the official funding opportunity number?

The official funding opportunity number is RFA AI 11 034.

What is the program title?

The title is Cooperative Study Group for Autoimmune Disease Prevention (U01).

What is the estimated total funding?

The estimated total funding listed for the program is $2,600,000.

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

When was the opportunity posted?

The opportunity was posted and created on June 17, 2011.

What is the closing date?

The original and current closing date is November 8, 2011.

Is this opportunity archived?

Yes. The archive date is December 9, 2011.

Which CFDA numbers are associated with this opportunity?

The opportunity is associated with CFDA numbers 93.847, 93.855, and 93.856, reflecting the cross-cutting nature of autoimmune disease prevention across immune-mediated and metabolic/endocrine disease areas.

Where can applicants find the full official announcement?

The full announcement is available through the NIH grants guide at http://grants.nih.gov/grants/guide/rfa_files/RFA_AI_11_034.html.

Who is the issuing agency?

The issuing agency is the National Institutes of Health (NIH).

Who should be contacted for access or technical issues with the posting?

For access or technical issues with the posting, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

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