Countermeasures Against Chemical Threats (CounterACT) Cooperative Research Projects (U01) | Apply Online

Opportunity Summary:

The Countermeasures Against Chemical Threats (CounterACT) Cooperative Research Projects (U01) opportunity (Funding Opportunity Number PAR 10 180) is a National Institutes of Health (NIH) funding program aimed at pushing forward practical medical treatments for harmful chemical exposures. The central goal is to develop new and improved therapeutics that could be used when toxic chemicals are released intentionally (for example, in a terrorist attack) or unintentionally (for example, through industrial accidents during production, storage, or transportation). The FOA makes clear that the program is not limited to classic military chemical warfare agents; it also explicitly targets toxic industrial chemicals and certain pesticides. Examples called out in the announcement include nerve agents such as sarin and VX, and other high risk chemicals such as cyanide, chlorine, parathion, and sodium fluoroacetate. In other words, the focus is on medical countermeasures that can realistically reduce illness and death after exposure to a wide range of dangerous chemicals that pose public health and national security risks.

From a research and development standpoint, the scope is intentionally translational, meaning it is meant to move beyond basic science and toward products that could plausibly be used in real emergencies. Projects can start as early as target identification and candidate discovery, then move through candidate characterization and optimization, and continue into in vivo efficacy testing. For projects that are sufficiently advanced and appropriate for that stage, the FOA also allows progression toward Investigational New Drug (IND) enabling work, IND submission, and even Phase 1 clinical trials. A defining requirement is that each funded project must be structured around clear milestones with discrete go or no go decision points. That milestone driven design is meant to enforce disciplined development planning, where teams can demonstrate progress, make evidence based decisions, and stop or redirect approaches that are not meeting performance expectations.

The funding mechanism is a cooperative agreement (U01), not a standard research project grant. Practically, that signals a more hands on partnership model with NIH, where the agency typically expects meaningful scientific and programmatic involvement during the project period compared with an R01. The FOA also notes that it runs in parallel with a separate opportunity of identical scientific scope for larger, center based programs, the CounterACT Research Centers of Excellence (U54), listed as PAR 10 181. The U01 track is therefore positioned for individual cooperative research projects, while the U54 track supports broader center structures, but both are aligned around the same overarching mission of developing medical countermeasures against chemical threats.

In terms of funding levels, the participating NIH Institutes planned to commit an average of about 6 million dollars per year during Fiscal Years 2011, 2012, and 2013 for new awards and competing renewals under this program. The announcement emphasizes that award size and duration are expected to vary widely because projects may sit at different stages of the translational pipeline and may require different kinds of resources (for example, medicinal chemistry optimization versus animal efficacy studies versus early clinical activities). The final number of awards and total dollars awarded would ultimately depend on the volume of applications received, their scientific and technical quality, their proposed timelines, and their requested budgets.

Eligibility is broad and includes many categories of applicants across academia, government, nonprofit, and industry. Eligible applicants listed include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non 501(c)(3) organizations), for profit organizations (other than small businesses), small businesses, state and local governments (including counties, cities, townships, special districts, and independent school districts), public housing authorities, and multiple types of Tribal entities. The FOA also explicitly includes a range of special designations and community anchored institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith based or community based organizations, regional organizations, and U.S. territories or possessions. There is no cost sharing or matching requirement indicated.

Key administrative details in the source information include a posted date of April 29, 2010, with NIH as the sponsoring agency. The activity spans multiple NIH related program areas as reflected by the CFDA numbers provided (including environmental health and several biomedical research domains). The listing includes an Additional Information link pointing to the NIH grants guide page for PAR 10 180, and provides NIH Office of Extramural Research (OER) webmaster contacts for applicants who have technical difficulty accessing or linking to the full announcement.

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