Opportunity Information: Apply for RFA HL 11 005
Apply for RFA HL 11 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Cross Organ Mechanism Associated Phenotypes for Genetic Analyses of Heart, Lung, Blood, and Sleep Diseases (MAPGen for HLBS) Research Centers (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.837 Cardiovascular Diseases Research 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research.
- This funding opportunity was created on Feb 24, 2010 and posted on Feb 24, 2010.
- Applicants must submit their applications by Sep 1, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $25,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Public housing authorities/Indian housing authorities For profit organizations other than small businesses County governments Native American tribal governments (Federally recognized) City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Special district governments Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Cross Organ Mechanism Associated Phenotypes for Genetic Analyses of Heart, Lung, Blood, and Sleep Diseases (MAPGen for HLBS) Research Centers (U01) opportunity, announced by the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH), is designed to build a multi-site research consortium focused on a different way of defining and studying disease. Instead of organizing research strictly around traditional clinical diagnoses (for example, a named heart condition versus a named lung condition), MAPGen aims to identify and characterize shared, underlying biological mechanisms that cut across organs and disease categories. The core idea is that many conditions affecting the heart, lungs, blood, and sleep systems may share common cellular and molecular network disruptions, and those disruptions may be better targets for prediction, prevention, diagnosis, and treatment than symptom-based labels alone.
At the center of the program is the concept of "mechanism associated phenotypes" that are consistent across organ systems. In practical terms, this means the consortium is expected to use modern and emerging knowledge about molecular pathways, cellular interactions, and biological networks to define traits that reflect pathobiology, then use those traits to group individuals in a way that is more biologically meaningful than classic clinical categories. The long-term goal is a shift toward mechanism-based medicine, where patients can be stratified by the processes driving disease in their bodies, enabling more tailored strategies for intervention and a clearer understanding of why similar symptoms can arise from different causes, or why different diagnoses can share the same underlying biology.
This funding opportunity supports Research Centers that will participate as part of the MAPGen consortium, operating under a Cooperative Agreement mechanism (U01). A U01 is distinct from a standard research grant in that it implies substantial programmatic involvement from NIH staff and a stronger emphasis on coordinated, consortium-style work. Awardees should expect to collaborate closely, align on shared goals, and contribute to common resources, methods, and outputs rather than operating as fully independent projects. The Research Centers supported under this announcement are intended to work in parallel with a separate but linked funding opportunity that solicits applications for a MAPGen Knowledge Base and Coordination Center (MAPGenKB). That companion component is meant to provide centralized coordination and shared infrastructure, supporting harmonization, data and knowledge integration, and cross-site collaboration so the consortium can function as a coherent whole.
In terms of scale, the NIH indicated that total funding across the full MAPGen effort, including both the Research Centers and the MAPGenKB, would be capped at about $25 million over the project period. The anticipated awards under this specific Research Center FOA were approximately 6 to 8 Research Centers, alongside 1 MAPGenKB award under the related announcement. This structure signals an intent to fund a small network of well-coordinated hubs rather than a large number of loosely connected projects, which fits the consortium's emphasis on shared frameworks and integrative science.
The opportunity is categorized as discretionary funding and uses the Cooperative Agreement instrument. The activity area is health, and the program is associated with multiple CFDA numbers reflecting the cross-cutting NHLBI mission space and the National Center on Sleep Disorders Research: 93.233 (sleep disorders), 93.837 (cardiovascular), 93.838 (lung), and 93.839 (blood diseases and resources). There is no cost sharing or matching requirement, which means applicants are not required to contribute non-federal funds as a condition of receiving the award.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (other than small businesses as well as small businesses), and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility language also explicitly includes organizations and institutions that often participate through targeted eligibility provisions, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, tribal governments and tribal organizations (including those not federally recognized, as specified), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, eligible federal agencies, and foreign (non-U.S.) entities.
Administratively, the opportunity was posted on February 24, 2010, with an original and current closing date of September 1, 2010, and an archive date of October 2, 2010. The Funding Opportunity Number is RFA-HL-11-005, and the title emphasizes that these are MAPGen Research Centers funded under a U01 cooperative agreement. The full announcement was made available through the NIH grants guide, with contact support routed through the NIH Office of Extramural Research (OER) webmaster for technical access issues.
Taken together, this FOA is best understood as an NIH-driven, team-science investment aimed at accelerating a shift from organ-by-organ and diagnosis-by-diagnosis research toward integrated, mechanism-based phenotyping and genetic analysis across heart, lung, blood, and sleep-related diseases. The consortium model, combined with a dedicated knowledge base and coordination center, reflects a strong emphasis on shared standards, cross-project interoperability, and building reusable resources that can support discovery of common biological mechanisms and, ultimately, more precise and effective clinical strategies grounded in underlying pathogenesis rather than outward presentation.
FAQs: MAPGen for HLBS Research Centers (U01) - RFA-HL-11-005
What is the MAPGen for HLBS Research Centers (U01) funding opportunity?
This opportunity is a National Institutes of Health (NIH) program led by the National Heart, Lung, and Blood Institute (NHLBI) to fund multi-site Research Centers under a cooperative agreement (U01). The program is called Cross Organ Mechanism Associated Phenotypes for Genetic Analyses of Heart, Lung, Blood, and Sleep Diseases (MAPGen for HLBS).
What is the main purpose of MAPGen?
MAPGen is designed to support a research consortium that studies disease in a different way: by identifying shared biological mechanisms that cut across organs and traditional disease categories, rather than focusing strictly on classic clinical diagnoses.
What does "cross-organ mechanism associated phenotypes" mean in this program?
In this program, "mechanism associated phenotypes" refers to traits or groupings of individuals defined by underlying pathobiology (such as cellular, molecular, and network disruptions) that are consistent across organ systems. The aim is to define phenotypes that reflect biology and mechanisms, not just symptoms or diagnostic labels.
Which disease areas are included in MAPGen for HLBS?
The program spans heart, lung, blood, and sleep-related diseases and conditions, reflecting NHLBI mission areas and the National Center on Sleep Disorders Research.
How is MAPGen different from traditional diagnosis-based research?
Traditional approaches often organize studies around named diagnoses (for example, one specific heart condition versus one specific lung condition). MAPGen emphasizes studying common underlying mechanisms that may explain why different diagnoses can share biology, or why similar symptoms can arise from different causes.
What is the long-term goal of the MAPGen approach?
The long-term goal is to accelerate a shift toward mechanism-based medicine, where patients can be stratified by the biological processes driving disease, potentially enabling better prediction, prevention, diagnosis, and treatment strategies.
What funding mechanism is used for these Research Centers?
The Research Centers are funded through a Cooperative Agreement (U01). This mechanism is intended for coordinated, consortium-style work with substantial involvement from NIH staff.
What does a U01 cooperative agreement imply for awardees?
A U01 implies that awardees should expect close collaboration with NIH staff and other awardees, alignment on shared goals, and contributions to common resources, methods, and outputs rather than operating as fully independent projects.
Is this a single-site or multi-site program?
It is explicitly designed as a multi-site consortium, with multiple Research Centers working together in parallel as part of a coordinated network.
How many Research Centers were anticipated to be funded?
The NIH anticipated approximately 6 to 8 MAPGen Research Centers under this announcement.
Is there a coordinating or central infrastructure component in addition to the Research Centers?
Yes. The Research Centers are intended to work in parallel with a separate, linked funding opportunity for a MAPGen Knowledge Base and Coordination Center (MAPGenKB), which is meant to support centralized coordination and shared infrastructure.
What is the role of the MAPGen Knowledge Base and Coordination Center (MAPGenKB)?
Based on the description provided, MAPGenKB is intended to provide consortium-wide coordination and shared infrastructure to support harmonization, data and knowledge integration, and cross-site collaboration so the consortium operates as a coherent whole.
How much total funding was planned for the overall MAPGen effort?
Total funding across the full MAPGen effort (including both the Research Centers and the MAPGenKB) was capped at about $25 million over the project period.
What type of funding opportunity is this (mandatory vs. discretionary)?
This opportunity is categorized as discretionary funding.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, meaning applicants are not required to contribute non-federal funds as a condition of receiving an award.
Who is eligible to apply?
Eligibility is broad and includes many domestic and non-domestic organization types, including higher education institutions, nonprofits, for-profits (including small businesses), and a wide range of government entities, among others.
Are foreign (non-U.S.) entities eligible to apply?
Yes. The eligibility language explicitly includes foreign (non-U.S.) entities.
Are U.S. territories or possessions included as eligible applicants?
Yes. U.S. territories or possessions are explicitly included in the eligibility description.
Are tribal governments and tribal organizations eligible?
Yes. The eligibility description includes tribal governments and tribal organizations, including those not federally recognized as specified.
Are minority-serving institutions and other targeted institution types included?
Yes. The eligibility description explicitly includes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and other similar institution types.
Are faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly listed as eligible.
Which federal agency announced and manages this opportunity?
The opportunity is associated with the National Heart, Lung, and Blood Institute (NHLBI) at the National Institutes of Health (NIH).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-HL-11-005.
What is the activity area for this funding opportunity?
The activity area is health.
Which CFDA numbers are associated with this program?
The program is associated with multiple CFDA numbers: 93.233 (sleep disorders), 93.837 (cardiovascular), 93.838 (lung), and 93.839 (blood diseases and resources).
When was the opportunity posted?
The opportunity was posted on February 24, 2010.
What was the closing date for applications?
The original and current closing date listed was September 1, 2010.
When was the opportunity archived?
The archive date was October 2, 2010.
Where was the full announcement made available?
The full announcement was made available through the NIH grants guide.
Who should be contacted for technical access issues related to the announcement?
Technical access issues were routed through the NIH Office of Extramural Research (OER) webmaster, as described in the opportunity information.
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