Opportunity Information: Apply for PAR 09 222
Apply for PAR 09 222
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Cutting Edge Basic Research Awards (CEBRA) (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Jun 25, 2009 and posted on Jun 25, 2009.
- Applicants must submit their applications by Dec 21, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $125,000.00 in funding.
- Eligible applicants include: Native American tribal governments (Federally recognized) Special district governments For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Public housing authorities/Indian housing authorities Private institutions of higher education Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Cutting Edge Basic Research Awards (CEBRA) (R21) opportunity (Funding Opportunity Number PAR 09 222) is a National Institutes of Health program administered through the National Institute on Drug Abuse (NIDA) to spark unusually innovative basic research on drug abuse and addiction, including new ways to prevent and treat substance use disorders. The central idea is to create space for bold, conceptually creative projects that sit outside the mainstream of NIDA's current research portfolio, especially work that may be considered too early-stage, unconventional, or exploratory for more traditional grant mechanisms. The program is explicitly aimed at high-risk, potentially high-impact science, where the payoff could be a meaningful shift in how the field understands addiction or approaches intervention, even if the project begins with limited prior evidence.
NIDA is looking for proposals that fit one of two main profiles. First, investigators can propose to test a highly novel and significant hypothesis where there is scant precedent or minimal preliminary data, as long as a successful outcome would substantially affect prevailing scientific thinking. Second, applicants can focus on developing, adapting, or applying innovative techniques or methods that could advance addiction research, including tools not traditionally used in drug abuse research but that have clear promise for doing so. In practical terms, the FOA is encouraging applicants to take intellectual risks, challenge assumptions, introduce new conceptual frameworks, or bring new methodological capabilities into the addiction science space, rather than extending well-established lines of work.
The funding mechanism is the NIH Exploratory/Developmental Grant (R21), with modifications specific to this announcement. R21 awards are typically used for early, exploratory projects intended to generate new insights, feasibility data, or methodological advances, and they are generally well-suited for projects that are not yet ready for a large-scale R01. Under this FOA, the award ceiling is listed as 125,000 (as provided in the source data). The program anticipates an annual total of about 2.5 million in awards and expects to make roughly 14 awards per year, though both the total funding level and the number of awards depend on the availability of funds and the quality and volume of applications received.
This is a discretionary grant program in the Education/Health activity area (CFDA 93.279, Drug Abuse and Addiction Research Programs) and does not require cost sharing or matching. The opportunity was posted on June 25, 2009, with an original and current closing date of December 21, 2011, and an archive date of January 21, 2012, meaning it is no longer active as written, but it provides a clear snapshot of the kind of high-innovation, early-stage basic research NIDA was seeking through the CEBRA concept at that time.
Eligibility is broad and spans many organization types, including state, county, and city governments; special district governments; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; public and private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations other than small businesses; small businesses; and independent school districts. The eligibility language also explicitly includes a range of additional entities such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and even non-U.S. entities (foreign organizations). This wide eligibility suggests NIDA wanted to attract unconventional perspectives and cross-sector participation, consistent with the program's emphasis on creativity and underrepresented research directions.
For applicants seeking the full official announcement details, the FOA link provided is http://grants.nih.gov/grants/guide/pa-files/PAR-09-222.html (as referenced in the source). Contact support listed in the announcement points to the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV) for technical access or linking issues related to the funding announcement.
Frequently Asked Questions (FAQs)
What is the Cutting Edge Basic Research Awards (CEBRA) (R21) opportunity?
The Cutting Edge Basic Research Awards (CEBRA) is a National Institutes of Health (NIH) funding opportunity administered through the National Institute on Drug Abuse (NIDA). It uses the NIH Exploratory/Developmental Grant mechanism (R21) to support unusually innovative basic research related to drug abuse and addiction, including new ideas that could inform prevention and treatment of substance use disorders.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is PAR 09 222.
Which NIH institute administers this program?
The program is administered by the National Institute on Drug Abuse (NIDA), which is part of the NIH.
What is the main goal of CEBRA?
The main goal is to create room for bold, conceptually creative basic research projects that fall outside the mainstream of NIDA's current research portfolio. The program emphasizes high-risk, potentially high-impact science that could shift how the field understands addiction or approaches intervention, even when prior evidence is limited.
What kind of research is CEBRA trying to encourage?
CEBRA is intended to encourage intellectual risk-taking in addiction science, such as challenging assumptions, introducing new conceptual frameworks, and pursuing unconventional or exploratory directions that might be considered too early-stage for more traditional grant mechanisms.
What are the two main profiles of projects NIDA is looking for under this FOA?
NIDA describes two primary project profiles:
- Testing a highly novel and significant hypothesis with scant precedent or minimal preliminary data, where success would substantially affect prevailing scientific thinking.
- Developing, adapting, or applying innovative techniques or methods that could advance addiction research, including tools not traditionally used in drug abuse research but that show clear promise.
Does this program support early-stage or exploratory work?
Yes. The FOA explicitly targets early-stage, unconventional, and exploratory projects, including those with limited preliminary evidence, as long as the potential scientific payoff could be substantial.
What grant mechanism does CEBRA use?
This opportunity uses the NIH Exploratory/Developmental Grant mechanism (R21), with modifications specific to this announcement.
What is an R21 generally used for in this context?
R21 awards are typically used for early, exploratory projects aimed at generating new insights, feasibility data, or methodological advances, particularly for work that is not yet ready for a larger-scale R01 project.
What is the award ceiling listed for this FOA?
The award ceiling is listed as 125,000 (as provided in the source information).
How much total funding did the program anticipate awarding each year?
The program anticipated an annual total of about 2.5 million in awards, depending on the availability of funds and the quality and volume of applications received.
About how many awards per year did NIDA expect to make?
NIDA expected to make roughly 14 awards per year, although this number could vary based on funds and application volume/quality.
What activity area is associated with this grant opportunity?
The activity area is Education/Health, and it is described as a discretionary grant program.
What is the CFDA number associated with this opportunity?
The CFDA number is 93.279, Drug Abuse and Addiction Research Programs.
Is cost sharing or matching required?
No. The opportunity does not require cost sharing or matching.
When was this funding opportunity posted?
The opportunity was posted on June 25, 2009.
What were the closing dates for this FOA?
The original and current closing date listed is December 21, 2011.
Is this funding opportunity still active?
No. The archive date is January 21, 2012, and the closing date was December 21, 2011, so the opportunity is no longer active as written.
Why might this FOA still be useful even though it is archived?
Even though it is no longer active, the announcement provides a snapshot of the type of high-innovation, early-stage basic research NIDA sought through the CEBRA concept during that period.
Who is eligible to apply?
Eligibility is broad and includes many organization types, such as:
- State, county, and city governments
- Special district governments
- Federally recognized tribal governments and other tribal organizations
- Public housing authorities/Indian housing authorities
- Public and private institutions of higher education
- Nonprofits with and without 501(c)(3) status
- For-profit organizations other than small businesses
- Small businesses
- Independent school districts
Are specific institution types explicitly mentioned as eligible?
Yes. The eligibility language explicitly includes (among others) Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and faith-based and community-based organizations.
Are U.S. territories, regional organizations, or federal agencies included in eligibility?
Yes. The eligibility list includes eligible federal agencies, U.S. territories or possessions, and regional organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility language explicitly includes non-U.S. entities (foreign organizations).
Where can applicants find the official funding opportunity announcement?
The FOA link provided is: http://grants.nih.gov/grants/guide/pa-files/PAR-09-222.html
Who is listed as the contact for technical access or linking issues related to the announcement?
The NIH Office of Extramural Research webmaster is listed for technical access or linking issues: FBOWebmaster@OD.NIH.GOV
What types of ideas or approaches does the FOA suggest are a good fit?
Based on the description, good-fit ideas include projects that are unusually innovative, outside the mainstream of NIDA's portfolio, high-risk/high-impact, and either (1) test a novel hypothesis with minimal precedent or (2) introduce innovative methods or tools that could meaningfully advance addiction research.
What kinds of projects might be less aligned with the stated intent?
The FOA emphasizes not simply extending well-established lines of work. Projects that mainly continue mainstream directions without a strong high-risk, creative, or unconventional component may be less aligned with the stated purpose of this specific announcement.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 09 222) also looked into and applied for these:
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| Cancer Intervention and Surveillance Modeling Network (CISNET) (U01) Apply for RFA CA 09 025 Funding Number: RFA CA 09 025 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| The Early Detection Research Network Biomarker Developmental Laboratories (U01) Apply for RFA CA 09 017 Funding Number: RFA CA 09 017 Agency: National Institutes of Health Category: Education Health Funding Amount: $400,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) for Individual Predoctoral Fellows in Nursing Research (F31) Apply for PAR 09 227 Funding Number: PAR 09 227 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Mechanisms Underlying the Links between Psychosocial Stress, Aging, the Brain and the Body (R01) Apply for PA 09 216 Funding Number: PA 09 216 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Diet, Epigenetic Events, and Cancer Prevention (R01) Apply for PA 09 234 Funding Number: PA 09 234 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Diet, Epigenetic Events, and Cancer Prevention (R21) Apply for PA 09 235 Funding Number: PA 09 235 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| HIV/AIDS, Drug Use, and Vulnerable Populations in the US (R01) Apply for PA 09 236 Funding Number: PA 09 236 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| HIV/AIDS, Drug Use, and Vulnerable Populations in the US (R21) Apply for PA 09 237 Funding Number: PA 09 237 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis (R21) Apply for PA 09 238 Funding Number: PA 09 238 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Behavioral Science Track Award for Rapid Transition (B/START) (R03) Apply for PAR 09 239 Funding Number: PAR 09 239 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Early Detection Research Network Clinical Validation Centers (U01) Apply for RFA CA 09 018 Funding Number: RFA CA 09 018 Agency: National Institutes of Health Category: Education Health Funding Amount: $600,000 |
| The Early Detection Research Network Biomarker Reference Laboratories (U24) Apply for RFA CA 09 019 Funding Number: RFA CA 09 019 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Early Detection Research Network Data Management and Coordinating Center and Statistics and Biomarker Resource Center (U24) Apply for RFA CA 09 020 Funding Number: RFA CA 09 020 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Limited Competition Support for Human Specimen Banking in NCI Supported Clinical Trials Cooperative Group Banks (CGB) (U24) Apply for RFA CA 09 504 Funding Number: RFA CA 09 504 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Substance Use and Abuse among U.S. Military Personnel, Veterans and their Families (R01) Apply for RFA DA 10 001 Funding Number: RFA DA 10 001 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Substance Use and Abuse among U.S. Military Personnel, Veterans and their Families (R21) Apply for RFA DA 10 002 Funding Number: RFA DA 10 002 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| NIMH Career Transition Award for Intramural Investigators (K22) Apply for PAR 09 246 Funding Number: PAR 09 246 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Innovations in Biomedical Computational Science and Technology Initiative (SBIR R43/R44) Apply for PAR 09 220 Funding Number: PAR 09 220 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Innovations in Biomedical Computational Science and Technology Initiative (STTR R41/R42) Apply for PAR 09 221 Funding Number: PAR 09 221 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Optimization of Small Molecule Probes for the Nervous System (R21) Apply for PAR 09 251 Funding Number: PAR 09 251 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
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