Opportunity Information: Apply for 16 549
Apply for 16 549
- The NSF in the science and technology and other research and development sector is offering a public funding opportunity titled "Cyber-Physical Systems" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 10.310, 20.200, 43.001, 47.041, 47.070, 93.286, 93.350, 93.396.
- This funding opportunity was created on Mar 15, 2016 and posted on Mar 15, 2016.
- Applicants must submit their applications by Jun 07, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $7,000,000.00 in funding.
- The number of recipients for this funding is limited to 32 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The National Science Foundation (NSF) Cyber-Physical Systems (CPS) grant opportunity (Funding Opportunity Number 16-549) supports research and education aimed at advancing the core science and engineering needed to design and build complex systems where software, computation, networking, and physical processes are tightly integrated. CPS is positioned as the next major wave beyond traditional embedded systems, with the potential to deliver much higher capability, adaptability, scalability, resiliency, safety, security, and usability. The solicitation frames CPS as a transformative technology on par with the Internet in terms of changing how people interact with engineered systems, and it highlights major application areas where CPS can drive innovation and U.S. competitiveness, including agriculture, energy, transportation, buildings and automation, healthcare, and manufacturing.
A central motivation in the announcement is that, even with strong progress over the prior five-plus years, the field still lacks a mature, reliable systems science for engineering "high-confidence" CPS. The program emphasizes that conventional analysis and design tools often cannot handle the real-world complexity of CPS or predict system behavior well, especially as connected ecosystems such as the Internet of Things scale toward billions of devices. As systems become more autonomous, distributed, and interdependent with open and uncertain environments, requirements for dependability, security, privacy, safety, and robustness rise sharply. The solicitation calls out the need for new architectural models and engineering approaches that can reconcile continuous and discrete dynamics, manage uncertainty, and go beyond traditional real-time guarantees that break down when systems are large, rapidly reconfiguring, and distributed across space, time, and organizational layers. It also stresses the importance of open interfaces, modularity, interoperability, and verification methods that can provide stronger assurances of correct and secure behavior.
Programmatically, the goal is to develop cross-cutting foundational principles that apply across CPS domains rather than producing narrow, domain-specific results. NSF is looking for work that reveals generalizable scientific and engineering concepts underpinning cyber-physical integration, while also accelerating transition to practice. To that end, the solicitation supports not only theory and methods, but also enabling tools and reusable hardware/software components, plus validation through prototypes and testbeds. It explicitly notes the growing convergence between CPS research and efforts related to Smart and Connected Communities and the Internet of Things, describing these as fertile areas for foundational advances as well as opportunities to mature technologies at different time horizons.
The opportunity is also notable for its multi-agency alignment. NSF indicates it is working closely with several federal partners to identify CPS research directions common across multiple application domains and to encourage faster translation into real-world use. Named partners include the U.S. Department of Homeland Security (DHS) Science and Technology Directorate, the U.S. Department of Transportation (DOT) Federal Highway Administration and DOT Intelligent Transportation Systems Joint Program Office, NASA Aeronautics Research Mission Directorate, multiple NIH institutes and centers (including NIBIB, OBSSR, NCI, and NCATS), and USDA's National Institute of Food and Agriculture (NIFA). This collaboration signals that proposals with broadly relevant foundations and credible pathways to impact in critical sectors are especially aligned with the solicitation's intent.
The solicitation offers three project classes based on scope, ambition, and level of integration. Breakthrough projects are designed for a single, significant leap in fundamental CPS science/engineering/technology that could change the field, particularly through new ways of bridging computing, communication, and control; these projects can request up to $500,000 total for up to 3 years. Synergy projects target innovation that truly requires multiple disciplines working in an integrated way toward a clear objective; these can request $500,001 to $1,000,000 total for 3 to 4 years. Frontier projects are the largest and are meant to tackle major CPS challenges that cannot realistically be solved by a collection of smaller, separate efforts; these can request $1,000,001 to $7,000,000 total for 4 to 5 years, reflecting an expectation of scale, coordination, and substantial deliverables.
Administratively, this is a discretionary funding opportunity using a Cooperative Agreement instrument, indicating an expectation of substantial involvement or coordination consistent with cooperative mechanisms. The opportunity lists multiple CFDA numbers (10.310, 20.200, 43.001, 47.041, 47.070, 93.286, 93.350, 93.396), reflecting the multi-agency, multi-domain character of the program. The agency is NSF, the posting date is March 15, 2016, and the closing date is June 7, 2016. The expected number of awards is 32, with an award ceiling of $7,000,000. Eligibility is listed broadly as "Others" with additional details referenced in the full announcement, which typically means applicants should consult the eligibility section carefully to confirm organizational fit and any constraints tied to specific tracks or partner-agency priorities.
Overall, the CPS program is seeking proposals that push beyond incremental improvements and instead build the scientific foundations, engineering methods, and validated technologies needed for trustworthy, scalable, and secure cyber-physical systems. Strongly aligned projects will typically combine rigorous foundational contributions with credible validation (for example, through prototypes or testbeds), and will address the hard realities of CPS: distributed operation, uncertainty, interdependence between cyber and physical elements, and the growing need for assurances in safety, security, reliability, and privacy.
NSF Cyber-Physical Systems (CPS) Grant (Funding Opportunity Number 16-549) - FAQs
What is the NSF Cyber-Physical Systems (CPS) grant opportunity (16-549)?
It is a National Science Foundation (NSF) funding opportunity supporting research and education to advance the core science and engineering needed to design and build complex cyber-physical systems (CPS), where software, computation, networking, and physical processes are tightly integrated.
How does the solicitation define a cyber-physical system (CPS)?
CPS are systems in which computation, communication, and control are deeply integrated with physical processes. The solicitation positions CPS as a step beyond traditional embedded systems, aiming for higher capability, adaptability, scalability, resiliency, safety, security, and usability.
Why is NSF investing in CPS now?
The announcement argues that CPS has transformative potential comparable to the Internet in how people interact with engineered systems. At the same time, it emphasizes that the field still lacks a mature and reliable systems science to engineer "high-confidence" CPS at real-world scale.
What does "high-confidence" CPS mean in the context of this program?
"High-confidence" refers to cyber-physical systems that can provide stronger assurances about correct, dependable, safe, secure, and privacy-respecting behavior, even under complexity, uncertainty, and distributed operation in open environments.
What kinds of problems is the program trying to solve?
The solicitation highlights gaps in conventional analysis and design tools for CPS, especially when systems become large, distributed, rapidly reconfiguring, and interconnected (for example, as Internet of Things ecosystems scale toward billions of devices). It calls for approaches that can better predict behavior, manage uncertainty, and handle interdependence across cyber and physical elements.
Which CPS qualities and requirements are emphasized?
The program stresses rising requirements for dependability, security, privacy, safety, and robustness as systems become more autonomous, distributed, and interdependent with open and uncertain environments.
What research themes does the solicitation explicitly call out?
It emphasizes the need for new architectural models and engineering approaches that reconcile continuous and discrete dynamics, manage uncertainty, and go beyond traditional real-time guarantees that may break down at scale. It also stresses open interfaces, modularity, interoperability, and verification methods that provide stronger assurances of correct and secure behavior.
Is the program looking for domain-specific work or cross-cutting foundations?
The stated goal is cross-cutting foundational principles that apply across CPS domains, rather than narrow, domain-specific results. Proposals are expected to reveal generalizable scientific and engineering concepts underpinning cyber-physical integration.
Does the program support applied work, tools, or prototypes?
Yes. In addition to theory and methods, the solicitation supports enabling tools and reusable hardware/software components, and it encourages validation through prototypes and testbeds to help accelerate transition to practice.
How does the solicitation relate to the Internet of Things (IoT) and Smart and Connected Communities?
The announcement notes a growing convergence between CPS research and efforts related to Smart and Connected Communities and the Internet of Things. These areas are described as fertile ground for foundational advances and for maturing technologies over different time horizons.
What application areas are highlighted as major CPS impact domains?
The solicitation highlights agriculture, energy, transportation, buildings and automation, healthcare, and manufacturing as major areas where CPS can drive innovation and strengthen U.S. competitiveness.
Which federal partners are named as aligned with this CPS solicitation?
NSF states it is working closely with multiple partners, including: the U.S. Department of Homeland Security (DHS) Science and Technology Directorate; the U.S. Department of Transportation (DOT) Federal Highway Administration and DOT Intelligent Transportation Systems Joint Program Office; NASA Aeronautics Research Mission Directorate; multiple NIH institutes and centers (including NIBIB, OBSSR, NCI, and NCATS); and USDA's National Institute of Food and Agriculture (NIFA).
Why does the multi-agency alignment matter for proposers?
The collaboration signals an interest in CPS research directions that are common across multiple application domains and that have credible pathways to translate into real-world use in critical sectors. Proposals with broadly relevant foundations and believable impact pathways are especially aligned with the stated intent.
What are the three project classes available under this opportunity?
The solicitation offers three project classes based on scope, ambition, and level of integration: Breakthrough, Synergy, and Frontier.
What is a Breakthrough project and what are its funding limits?
Breakthrough projects aim for a single significant leap in fundamental CPS science, engineering, or technology that could change the field, particularly through new ways of bridging computing, communication, and control. They can request up to $500,000 total for up to 3 years.
What is a Synergy project and what are its funding limits?
Synergy projects target innovation that truly requires multiple disciplines working in an integrated way toward a clear objective. They can request $500,001 to $1,000,000 total for 3 to 4 years.
What is a Frontier project and what are its funding limits?
Frontier projects are the largest projects and are intended to tackle major CPS challenges that cannot realistically be solved by a collection of smaller, separate efforts. They can request $1,000,001 to $7,000,000 total for 4 to 5 years.
What is the maximum award amount under this opportunity?
The award ceiling listed is $7,000,000, consistent with the maximum Frontier project budget range.
How many awards does NSF expect to make?
The expected number of awards is 32.
What funding instrument is used for this opportunity?
The solicitation is a discretionary funding opportunity using a Cooperative Agreement instrument, which indicates an expectation of substantial involvement or coordination consistent with cooperative mechanisms.
Who is the sponsoring agency?
The sponsoring agency is the National Science Foundation (NSF).
What are the posting date and closing date?
The posting date is March 15, 2016, and the closing date is June 7, 2016.
What CFDA numbers are associated with this program?
The opportunity lists multiple CFDA numbers: 10.310, 20.200, 43.001, 47.041, 47.070, 93.286, 93.350, and 93.396.
What is listed for eligibility?
Eligibility is listed broadly as "Others," with additional details referenced in the full announcement. Applicants are expected to consult the eligibility section of the full solicitation to confirm organizational fit and any constraints tied to specific tracks or partner-agency priorities.
What proposal characteristics appear strongly aligned with the solicitation?
Based on the description, strongly aligned projects typically push beyond incremental improvements, contribute generalizable foundations, and include credible validation (such as prototypes or testbeds). The solicitation also emphasizes addressing distributed operation, uncertainty, interdependence, and the need for strong assurances in safety, security, reliability, privacy, and robustness.
Browse more opportunities from the same category: Science and Technology and other Research and Development
Next opportunity: OR/WA - Black Canyon Research Natural Area (RNA) Monitoring and Guidebook
Previous opportunity: Knowledge, Experience and Beliefs of the Supernatural Environment
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for 16 549
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (16 549) also looked into and applied for these:
| Funding Opportunity |
|---|
| DoD Ovarian Cancer Academy - Early-Career Investigator Award Apply for W81XWH 16 OCRP OCA Funding Number: W81XWH 16 OCRP OCA Agency: DOD-AMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Cooperative Ecosystem Studies Unit, Great Basin CESU Apply for G16AS00045 Funding Number: G16AS00045 Agency: DOI-USGS1 Category: Science and Technology and other Research and Development Funding Amount: $35,000 |
| DoD Ovarian Cancer Pilot Award Apply for W81XWH 16 OCRP PA Funding Number: W81XWH 16 OCRP PA Agency: DOD-AMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Cooperative Ecosystem Studies Unit, Pacific Northwest CESU Apply for G16AS00046 Funding Number: G16AS00046 Agency: DOI-USGS1 Category: Science and Technology and other Research and Development Funding Amount: $701,000 |
| Cooperative Ecosystem Studies Unit, Great Lakes Northern Forests (CESU) Apply for G16AS00044 Funding Number: G16AS00044 Agency: DOI-USGS1 Category: Science and Technology and other Research and Development Funding Amount: $60,000 |
| DoD Ovarian Cancer Clinical Development Award Apply for W81XWH 16 OCRP CDA Funding Number: W81XWH 16 OCRP CDA Agency: DOD-AMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Ovarian Cancer Investigator-Initiated Research Award Apply for W81XWH 16 OCRP IIRA Funding Number: W81XWH 16 OCRP IIRA Agency: DOD-AMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Advanced Rehabilitation Research Training (ARRT) Program - Health and Function Apply for HHS 2016 ACL NIDILRR AR 0149 Funding Number: HHS 2016 ACL NIDILRR AR 0149 Agency: HHS-ACL Category: Science and Technology and other Research and Development Funding Amount: $150,000 |
| Advanced Rehabilitation Research Training (ARRT) Program - Employment Apply for HHS 2016 ACL NIDILRR AR 0150 Funding Number: HHS 2016 ACL NIDILRR AR 0150 Agency: HHS-ACL Category: Science and Technology and other Research and Development Funding Amount: $150,000 |
| Advanced Rehabilitation Research Training (ARRT) Program - Community Living and Participation Apply for HHS 2016 ACL NIDILRR AR 0151 Funding Number: HHS 2016 ACL NIDILRR AR 0151 Agency: HHS-ACL Category: Science and Technology and other Research and Development Funding Amount: $150,000 |
| US Ignite: Apply for 16 553 Funding Number: 16 553 Agency: NSF Category: Science and Technology and other Research and Development Funding Amount: $3,000,000 |
| Development of Large Diameter Silicon Carbide Substrate and Epitaxial Processes Apply for RFI AFRL RQKS 2016 0002 Funding Number: RFI AFRL RQKS 2016 0002 Agency: DOD-AFRL Category: Science and Technology and other Research and Development Funding Amount: $13,500,000 |
| Next Generation Social Science (NGS2) Apply for DARPA BAA 16 32 Funding Number: DARPA BAA 16 32 Agency: DOD-DARPA-DSO Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Air Force Fiscal Year 2017 Young Investigator Research Program (YIP) Apply for BAA AFRL AFOSR 2016 0006 Funding Number: BAA AFRL AFOSR 2016 0006 Agency: DOD-AFOSR Category: Science and Technology and other Research and Development Funding Amount: $360,000 |
| Climate and Water Resources Research and Related Technical Support Apply for BOR DO 16 011 Funding Number: BOR DO 16 011 Agency: DOI-BOR Category: Science and Technology and other Research and Development Funding Amount: $2,500,000 |
| Dear Colleague Letter: Advanced Cellular Biomanufacturing Apply for 16 053 Funding Number: 16 053 Agency: NSF Category: Science and Technology and other Research and Development Funding Amount: $300,000 |
| ROSES 2016: Maturation of Instruments for Solar System Exploration Apply for NNH16ZDA001N MATISSE Funding Number: NNH16ZDA001N MATISSE Agency: NASA-HQ Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| ROSES 2016: Earth Surface and Interior Apply for NNH16ZDA001N ESI Funding Number: NNH16ZDA001N ESI Agency: NASA-HQ Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Transformation and retention of nutrients in rivermouths of the Great Lakes Apply for USGS 16 FA 0090 Funding Number: USGS 16 FA 0090 Agency: DOI-USGS1 Category: Science and Technology and other Research and Development Funding Amount: $78,675 |
| Center for Research and Exploration in Space Science and Technology II (CRESST II Apply for NNG16541308C Funding Number: NNG16541308C Agency: NASA-GSFC Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants

Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "16 549", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.
