Opportunity Information: Apply for RFA HG 11 026
Apply for RFA HG 11 026
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Data Analysis and Coordination Center for the Encyclopedia of DNA Elements (ENCODE) (U41)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research.
- This funding opportunity was created on Oct 4, 2011 and posted on Oct 4, 2011.
- Applicants must submit their applications by Dec 21, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,500,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 2 candidate(s).
- Eligible applicants include: Small businesses Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education County governments Special district governments Public housing authorities/Indian housing authorities Independent school districts Private institutions of higher education City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This funding opportunity (RFA HG 11-026) is a National Institutes of Health (NIH), National Human Genome Research Institute (NHGRI) solicitation for cooperative agreement applications to run a central hub that can both manage ENCODE data and help the consortium analyze it in a coordinated way. ENCODE (and modENCODE) has spent years mapping and cataloging functional DNA elements across the human genome and several key model organisms, and those reference catalogs are now widely used by scientists to understand basic genome biology and to interpret results from studies that link genetic variation to disease. The purpose of this award is to strengthen and extend that impact by supporting a dedicated ENCODE Data Coordination and Analysis Center (EDCAC) to serve the ongoing ENCODE Project.
The EDCAC is expected to operate as a combined data infrastructure and analysis coordination resource with two major components. The first is the Data Coordination (DC) component, which focuses on the practical and technical backbone needed for a large consortium: building, hosting, and maintaining databases that can track submissions, store project outputs, and provide reliable, user-friendly access to ENCODE datasets for both consortium members and the broader research community. In practice, this implies responsibilities like organizing data and metadata, ensuring datasets are findable and retrievable, supporting consistent data submission and tracking workflows, and maintaining public access mechanisms that enable downstream reuse.
The second component is the Data Analysis (DA) component, which is aimed at making the whole greater than the sum of its parts by coordinating integrative analyses across the many datasets produced by ENCODE. Rather than each lab analyzing its own data in isolation, the DA function is meant to help align analytical approaches, encourage cross-assay and cross-sample integration, and support consortium-wide efforts to interpret functional genomic elements at scale. The overall emphasis is on coordination and assistance for integrative analysis, meaning the center is expected to play an enabling role that helps data generated by many groups be combined, compared, and interpreted consistently.
Mechanistically, this opportunity uses a cooperative agreement (U41), which typically means substantial programmatic involvement and partnership with NIH staff compared with a standard research grant. The announcement falls under the health funding activity category and is listed as discretionary. NHGRI anticipated making about two awards, with an estimated total funding level of $5,500,000 for the solicitation.
Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants span public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (including small businesses), and multiple levels of government (state, county, city/township, special district governments, public housing authorities, and independent school districts). The opportunity also explicitly includes a range of additional eligible entities such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), federally eligible agencies, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and tribal governments and tribal organizations (including those other than federally recognized tribal governments, as specified). Foreign institutions are eligible to apply, non-U.S. components of U.S. organizations may apply, and foreign components are allowed as defined by NIH policy. There is no cost sharing or matching requirement.
Key dates show the opportunity was posted and created on October 4, 2011, with an original and current closing date of December 21, 2011, and an archive date of January 21, 2012. The CFDA number associated with this program is 93.172 (Human Genome Research). For full details, NIH provided an announcement link (http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-11-026.html) and directs applicants with access or linking issues to the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
1) What is this funding opportunity?
This is NIH, National Human Genome Research Institute (NHGRI) funding opportunity RFA HG 11-026. It solicits cooperative agreement (U41) applications to run a central hub for the ENCODE Project called an ENCODE Data Coordination and Analysis Center (EDCAC).
2) What is the overall purpose of the award?
The purpose is to strengthen and extend the impact of ENCODE (and modENCODE) reference catalogs by supporting a dedicated center that can both manage ENCODE data and coordinate consortium-wide, integrative data analysis for the ongoing ENCODE Project.
3) What is ENCODE (and modENCODE) in the context of this opportunity?
ENCODE (and modENCODE) has spent years mapping and cataloging functional DNA elements across the human genome and several key model organisms. Those reference catalogs are widely used to understand genome biology and interpret results from studies linking genetic variation to disease.
4) What is the EDCAC expected to do?
The EDCAC is expected to operate as a combined data infrastructure and analysis coordination resource serving the ENCODE consortium and the broader research community.
5) What are the two major components of the EDCAC?
The center has two major components: (1) a Data Coordination (DC) component and (2) a Data Analysis (DA) component.
6) What is the Data Coordination (DC) component responsible for?
The DC component focuses on the practical and technical backbone needed for a large consortium. This includes building, hosting, and maintaining databases to track submissions, store project outputs, and provide reliable, user-friendly access to ENCODE datasets for both consortium members and the broader research community.
7) What types of data management functions are implied under Data Coordination?
Based on the description, Data Coordination implies responsibilities such as organizing data and metadata, ensuring datasets are findable and retrievable, supporting consistent data submission and tracking workflows, and maintaining public access mechanisms that enable downstream reuse.
8) Who is expected to use the EDCAC data access resources?
Data access resources are intended for both ENCODE consortium members and the broader research community.
9) What is the Data Analysis (DA) component intended to do?
The DA component is intended to coordinate integrative analyses across the many datasets produced by ENCODE so the consortium can interpret functional genomic elements at scale in a coordinated way.
10) Does the DA component replace analysis done by individual labs?
The opportunity emphasizes coordination and assistance for integrative analysis rather than isolated, lab-by-lab analysis. The DA function is described as enabling consortium-wide integration, comparison, and consistent interpretation across datasets produced by many groups.
11) What is meant by "integrative analyses" in this solicitation?
Integrative analyses, as described here, involve aligning analytical approaches across datasets, encouraging cross-assay and cross-sample integration, and supporting consortium-wide efforts so data generated by many groups can be combined, compared, and interpreted consistently.
12) What funding mechanism is used?
This opportunity uses a cooperative agreement mechanism (U41).
13) What does it mean that this is a cooperative agreement (U41)?
A cooperative agreement typically involves substantial programmatic involvement and partnership with NIH staff compared with a standard research grant, based on the description provided.
14) Which NIH Institute is sponsoring this opportunity?
The sponsoring Institute is the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH).
15) What activity category is this opportunity listed under?
It is listed under the health funding activity category and is described as discretionary.
16) How many awards did NHGRI anticipate making?
NHGRI anticipated making about two awards.
17) What is the estimated total funding level mentioned?
The solicitation lists an estimated total funding level of $5,500,000.
18) Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
19) Who is eligible to apply?
Eligibility is broad and includes many types of U.S. and non-U.S. organizations, including higher education institutions, nonprofits, for-profits (including small businesses), and multiple levels of government.
20) Are U.S. colleges and universities eligible?
Yes. Eligible applicants include public and private institutions of higher education.
21) Are nonprofit organizations eligible, including those without 501(c)(3) status?
Yes. The opportunity includes nonprofits with and without 501(c)(3) status.
22) Are for-profit organizations eligible?
Yes. For-profit organizations are eligible, including small businesses.
23) Are government entities eligible to apply?
Yes. Eligible government entities include state, county, city/township, and special district governments, as well as public housing authorities and independent school districts.
24) Are minority-serving and special-designation institutions explicitly included?
Yes. The opportunity explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs), among others.
25) Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly included among eligible entities.
26) Are U.S. territories and tribal entities eligible?
Yes. The opportunity includes U.S. territories or possessions, tribal governments, and tribal organizations, including those other than federally recognized tribal governments as specified in the eligibility language.
27) Are foreign institutions eligible to apply?
Yes. Foreign institutions are eligible to apply.
28) Can non-U.S. components of U.S. organizations apply?
Yes. Non-U.S. components of U.S. organizations may apply.
29) Are foreign components allowed?
Yes. Foreign components are allowed as defined by NIH policy.
30) What are the key dates for this opportunity?
The opportunity was posted and created on October 4, 2011. The original and current closing date is December 21, 2011. The archive date is January 21, 2012.
31) What is the CFDA number associated with this program?
The CFDA number listed is 93.172 (Human Genome Research).
32) Where can applicants find the full announcement?
The full announcement is linked at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HG-11-026.html
33) Who should be contacted if there are issues accessing or linking to the announcement?
NIH directs applicants with access or linking issues to contact the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
34) What kind of center is being solicited (in practical terms)?
A dedicated central hub that combines (a) operational data infrastructure (databases, submission tracking, storage, public access) with (b) consortium-wide coordination for integrative analysis across ENCODE datasets.
Browse more opportunities from the same category: Health
Next opportunity: Computational Analysis of the Encyclopedia of DNA Elements (ENCODE) Data (U01)
Previous opportunity: Expanding the Encyclopedia of DNA Elements (ENCODE) in the Human and Model Organisms (U54)
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