Opportunity Information: Apply for RFA HL 12 025
Apply for RFA HL 12 025
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Data Coordinating Center for the Cardiovascular Cell Therapy Research Network (CCTRN) (UM1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837 Cardiovascular Diseases Research.
- This funding opportunity was created on Apr 20, 2011 and posted on Apr 20, 2011.
- Applicants must submit their applications by Jun 22, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Special district governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) County governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Small businesses Private institutions of higher education State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Organizations) are not eligible to apply. Foreign (non U.S.) components of U.S. Organizations are not allowed.
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Opportunity Summary:
This funding opportunity, RFA HL 12 025, is a National Institutes of Health (NIH) solicitation for a Data Coordinating Center (DCC) to support the continuation of the Cardiovascular Cell Therapy Research Network (CCTRN). The overall aim of the CCTRN is to speed up and strengthen the clinical evaluation of new cell-based therapies for people with cardiovascular disease. Rather than funding a single stand-alone study, the network model is meant to keep a durable, trial-ready infrastructure in place so multiple collaborative clinical trials can be developed, coordinated, and carried out over time with consistent methods and shared standards, ultimately targeting improvements in cardiovascular outcomes.
The specific role supported under this announcement is the Data Coordinating Center, funded through a cooperative agreement mechanism (UM1). A cooperative agreement indicates that NIH anticipates substantial involvement in the program, meaning the awardee will work closely with NIH staff in coordinating and managing network activities. In practical terms, the DCC is typically responsible for the central functions that allow multi-site clinical trials to run smoothly and produce credible, analyzable data. That usually includes designing and managing data systems, establishing common data elements and case report forms, overseeing data quality and completeness, coordinating statistical analysis plans, supporting trial operations (such as randomization and data flows), producing network-wide reports, and helping maintain regulatory and safety reporting processes that are consistent across studies. The DCC is intended to be a hub that ensures the network can run more than one trial efficiently, compare results across studies, and maintain uniform standards over the life of the network.
This FOA is paired with a separate solicitation, RFA HL 12 026, which seeks applications for Regional Clinical Centers (RCCs). Together, the RCCs and the DCC form the core operating structure of the CCTRN: the RCCs are generally where participants are recruited and treated and where clinical procedures occur, while the DCC provides the centralized coordination, data management, and analytic backbone needed for multi-center trials. The combined purpose is to support a coordinated national effort to test cardiovascular cell therapy strategies in a rigorous, collaborative clinical trial environment.
The opportunity is categorized as discretionary funding and falls under the health funding activity category, with CFDA number 93.837 (Cardiovascular Diseases Research). There is no cost sharing or matching requirement, which means applicants are not required to commit non-federal funds as a condition of receiving the award.
The eligible applicant pool is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories), for-profit organizations other than small businesses, and small businesses. Governmental entities such as state governments, county governments, city or township governments, special district governments, and public housing authorities/Indian housing authorities are also included. The eligibility list further clarifies that certain mission-focused institution types and organizations are eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and tribal entities (with multiple tribal categories explicitly named), along with faith-based or community-based organizations and regional organizations. Non-U.S. entities (foreign organizations) are not eligible to apply, and foreign components of U.S. organizations are not allowed, keeping the work fully within eligible U.S.-based organizational structures.
Key dates show the announcement was posted and created on April 20, 2011, with an original and current closing date of June 22, 2011, and an archive date of July 23, 2011. The sponsoring agency is NIH, and the full announcement was made available through the NIH Grants Guide at the provided link. For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs) - RFA HL 12 025 (CCTRN Data Coordinating Center)
What is RFA HL 12 025?
RFA HL 12 025 is a National Institutes of Health (NIH) funding opportunity announcement to support a Data Coordinating Center (DCC) for the continuation of the Cardiovascular Cell Therapy Research Network (CCTRN).
What is the purpose of the Cardiovascular Cell Therapy Research Network (CCTRN)?
The overall aim of the CCTRN is to speed up and strengthen the clinical evaluation of new cell-based therapies for people with cardiovascular disease by maintaining a durable, trial-ready network infrastructure that can support multiple collaborative clinical trials over time using consistent methods and shared standards.
Is this funding for a single clinical study?
No. The network model is intended to maintain an ongoing infrastructure so that multiple collaborative clinical trials can be developed, coordinated, and conducted over time rather than supporting only one stand-alone study.
What is being funded under this announcement?
This announcement funds the Data Coordinating Center (DCC), which serves as the centralized coordination, data management, and analytic hub for multi-site clinical trials conducted within the CCTRN.
What award mechanism is used for this opportunity?
The DCC is funded through a cooperative agreement mechanism (UM1).
What does a cooperative agreement (UM1) imply for the project?
A cooperative agreement indicates that NIH anticipates substantial involvement in the program. In practice, this means the awardee is expected to work closely with NIH staff to coordinate and manage network activities.
What are typical responsibilities of the Data Coordinating Center (DCC) in a multi-site clinical trial network?
Based on the description provided, the DCC typically performs central functions that allow multi-site trials to operate smoothly and generate credible, analyzable data, including:
- Designing and managing data systems for the network
- Establishing common data elements and case report forms
- Overseeing data quality and completeness
- Coordinating statistical analysis plans
- Supporting trial operations such as randomization and data flows
- Producing network-wide reports
- Helping maintain consistent regulatory and safety reporting processes across studies
Why is a centralized DCC important for the CCTRN?
The DCC is intended to ensure the network can run more than one trial efficiently, compare results across studies, and maintain uniform standards across the life of the network.
How does this opportunity relate to Regional Clinical Centers (RCCs)?
This funding opportunity is paired with a separate solicitation, RFA HL 12 026, which seeks applications for Regional Clinical Centers (RCCs). Together, the RCCs and the DCC form the core operating structure of the CCTRN.
What is the role difference between RCCs and the DCC within the CCTRN?
RCCs are generally where participants are recruited and treated and where clinical procedures occur. The DCC provides the centralized coordination, data management, and analytic backbone needed for multi-center trials.
What type of funding category does this opportunity fall under?
The opportunity is categorized as discretionary funding and falls under the health funding activity category.
What is the CFDA number for this program area?
The CFDA number listed is 93.837, Cardiovascular Diseases Research.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement, meaning applicants are not required to commit non-federal funds as a condition of receiving the award.
Who is eligible to apply?
The eligible applicant pool is broad and includes U.S.-based organizations and government entities, including:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories)
- For-profit organizations other than small businesses
- Small businesses
- State governments
- County governments
- City or township governments
- Special district governments
- Public housing authorities/Indian housing authorities
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving Institutions
- Alaska Native and Native Hawaiian Serving Institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Tribal entities (multiple tribal categories explicitly named)
- Faith-based or community-based organizations
- Regional organizations
Are non-U.S. (foreign) organizations eligible to apply?
No. Non-U.S. entities (foreign organizations) are not eligible to apply.
Are foreign components of U.S. organizations allowed?
No. Foreign components of U.S. organizations are not allowed under this opportunity.
When was the funding opportunity posted?
The announcement was posted (and created) on April 20, 2011.
What is the application closing date for RFA HL 12 025?
The original and current closing date listed is June 22, 2011.
When was the opportunity archived?
The archive date listed is July 23, 2011.
Which federal agency sponsors this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
Where was the full announcement published?
The full announcement was made available through the NIH Grants Guide at the provided link in the opportunity description.
Who should be contacted for technical issues accessing or linking to the announcement?
For technical issues accessing or linking to the announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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