Opportunity Information: Apply for RFA HD 08 027

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Data Coordinating Center for the Collaborative Pediatric Critical Care Research Network (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Dec 3, 2008 and posted on Dec 3, 2008.
  • Applicants must submit their applications by Mar 31, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $3,052,000.00 to eligible and selected applicants.
  • Eligible applicants include: For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) .
Apply for RFA HD 08 027

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Opportunity Summary:

This funding opportunity is a National Institutes of Health (NIH) cooperative agreement from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to support a single Data Coordinating Center (DCC) for the Collaborative Pediatric Critical Care Research Network (CPCCRN). The overall aim of CPCCRN is to run a coordinated, multicenter clinical research program in pediatric critical care, with a particular emphasis on understanding outcomes that extend beyond the ICU stay, including longer term outcomes for children and their families. In practical terms, the DCC is expected to serve as the central hub that enables multiple hospitals and clinical site centers to operate as one coherent research network by standardizing processes and coordinating the data and protocol infrastructure needed to carry out studies across sites.

The award uses the U01 mechanism, which is a cooperative agreement. That matters because it signals substantial federal scientific or programmatic involvement compared with a traditional research project grant. Under a U01, the DCC is not simply funded to do work independently; it is funded to actively collaborate with NICHD and the CPCCRN sites to implement network studies. This opportunity is designed to run in parallel with a companion solicitation that supports the network's Clinical Site Centers under a U10 mechanism. Together, the U01 DCC and the U10 clinical centers form the operational structure of CPCCRN: the clinical centers enroll patients and conduct study procedures, while the DCC provides centralized coordination so that the studies are consistent, high quality, and analyzable across all participating institutions.

NICHD anticipated making one award for the DCC. The institute planned to commit roughly 3.52 million dollars in FY 2010 to support this single coordinating center, and the announcement specifies that this total includes about 1.5 million dollars earmarked for patient and protocol costs that would be administered by the DCC. That detail suggests the DCC would not only manage data and analytics but would also serve as the financial and administrative conduit for certain network-level study expenses tied to protocol implementation and participant-related costs, reinforcing its role as the operational backbone of the network.

The opportunity is categorized as discretionary funding and falls under the health-related activity area (CFDA 93.865, Child Health and Human Development Extramural Research). There is no cost sharing or matching requirement, which typically reduces barriers for applicants and clarifies that the federal award is intended to cover the allowable project costs without requiring a specific institutional financial commitment beyond standard grant support obligations.

Eligibility is broad and includes a wide range of organizational types: public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses, and small businesses. The announcement also notes additional eligible applicants such as federal agencies and institutions that serve specific populations, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and other tribally controlled institutions. This breadth indicates NICHD was open to a variety of institutional homes for the DCC, as long as the applicant could credibly provide the specialized infrastructure and expertise needed to coordinate a national multicenter pediatric critical care research network.

Timing details in the listing indicate the opportunity was posted on December 3, 2008, with an application closing date of March 31, 2009, and an archive date of May 1, 2009. The funding opportunity number and title are provided in the source information, and an additional information link points to the full NIH RFA page where the detailed requirements, scope, responsibilities, and submission instructions would be described. Contact information is routed through the NIH Office of Extramural Research (OER) webmaster for technical access and linking issues, indicating that the primary public-facing contact in the excerpt is focused on announcement access rather than scientific questions.

In short, this FOA sought one experienced organization to function as the CPCCRN Data Coordinating Center under a cooperative agreement, working closely with NICHD and with CPCCRN clinical site centers to support rigorous multicenter pediatric critical care studies and to enable the network's focus on longer term outcomes for critically ill children and their families, backed by a multi-million-dollar federal commitment that included dedicated patient and protocol cost support administered through the DCC.

Frequently Asked Questions (FAQs)

What is this funding opportunity?

This is a National Institutes of Health (NIH) cooperative agreement funding opportunity from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to support a single Data Coordinating Center (DCC) for the Collaborative Pediatric Critical Care Research Network (CPCCRN).

Which NIH Institute is sponsoring the award?

The sponsoring NIH Institute is NICHD (Eunice Kennedy Shriver National Institute of Child Health and Human Development).

What is CPCCRN, and what is its overall goal?

CPCCRN is a collaborative, multicenter pediatric critical care clinical research network. Its overall aim is to run a coordinated clinical research program in pediatric critical care, with particular emphasis on understanding outcomes that extend beyond the ICU stay, including longer term outcomes for children and their families.

What is a Data Coordinating Center (DCC) in the context of CPCCRN?

The DCC is expected to function as the central hub that enables multiple hospitals and clinical site centers to operate as one coherent research network. This includes standardizing processes and coordinating the data and protocol infrastructure needed to carry out studies consistently across sites.

How does the DCC fit into the broader CPCCRN structure?

The DCC (funded under a U01 cooperative agreement) works in parallel with CPCCRN Clinical Site Centers that are supported through a companion solicitation under a U10 mechanism. The clinical centers enroll patients and conduct study procedures, while the DCC provides centralized coordination so studies are consistent, high quality, and analyzable across all participating institutions.

What funding mechanism is used for the DCC award?

The DCC award uses the U01 mechanism, which is a cooperative agreement.

What does it mean that this is a U01 cooperative agreement?

A U01 cooperative agreement signals substantial federal scientific or programmatic involvement compared with a traditional research project grant. In practice, the DCC is funded to actively collaborate with NICHD and CPCCRN sites to implement network studies rather than operating independently.

How many awards did NICHD anticipate making?

NICHD anticipated making one award to support a single CPCCRN Data Coordinating Center.

How much funding was planned for the DCC?

NICHD planned to commit approximately $3.52 million in FY 2010 to support the single DCC.

Does the stated total funding include patient or protocol costs?

Yes. The announcement specifies that the total includes about $1.5 million earmarked for patient and protocol costs that would be administered by the DCC.

What does it imply that the DCC administers patient and protocol costs?

Based on the description provided, it suggests the DCC is expected to play a financial and administrative role for certain network-level study expenses tied to protocol implementation and participant-related costs, in addition to managing data and coordination functions.

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

What type of funding category is this opportunity?

It is categorized as discretionary funding.

What is the activity area and CFDA number listed for this opportunity?

The opportunity is in a health-related activity area and is listed under CFDA 93.865 (Child Health and Human Development Extramural Research).

Which organizations are eligible to apply?

Eligibility is broad and includes: public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities); for-profit organizations other than small businesses; and small businesses.

Are federal agencies eligible to apply?

Yes. The eligibility list notes that federal agencies are among the additional eligible applicants.

Are minority-serving and tribally affiliated institutions eligible?

Yes. The eligibility description includes institutions that serve specific populations, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and other tribally controlled institutions.

When was the opportunity posted, and what were the key dates?

The listing indicates the opportunity was posted on December 3, 2008. The application closing date was March 31, 2009. The archive date was May 1, 2009.

Is this opportunity still open?

Based on the dates provided (closing date March 31, 2009, archive date May 1, 2009), this listing reflects a past funding opportunity rather than an open competition.

Is there a companion solicitation associated with this DCC opportunity?

Yes. The DCC opportunity is designed to run in parallel with a companion solicitation that supports CPCCRN Clinical Site Centers under a U10 mechanism.

Where can applicants find full details and instructions?

The excerpt notes an additional information link pointing to the full NIH RFA page, where detailed requirements, scope, responsibilities, and submission instructions would be described.

Who is listed as the contact in the provided information?

The public-facing contact in the excerpt is routed through the NIH Office of Extramural Research (OER) webmaster for technical access and linking issues, rather than a scientific or program contact.

What is the main purpose of funding a single DCC for a multicenter network?

The DCC is intended to provide centralized coordination so that studies conducted across multiple hospitals and clinical site centers use standardized processes and shared data/protocol infrastructure, enabling consistent execution, quality, and cross-site analysis.

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