Opportunity Information: Apply for RFA HL 15 024
Apply for RFA HL 15 024
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Definition of Resilience and Pre Symptomatic Disease in Lung Health and Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Oct 3, 2014 and posted on Oct 3, 2014.
- Applicants must submit their applications by Jan 21, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments Public and State controlled institutions of higher education Private institutions of higher education Independent school districts For profit organizations other than small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) State governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses City or township governments Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity RFA-HL-15-024, titled "Definition of Resilience and Pre Symptomatic Disease in Lung Health and Disease (R01)," is a discretionary research grant program intended to support studies that can identify what early, measurable biological features signal either (1) a person is on a path toward chronic lung disease before symptoms appear, or (2) a person is resilient and remains healthy despite exposures or risk factors. The central idea is to move the field upstream: instead of focusing only on established disease, the FOA encourages prospective research that can define and/or validate pulmonary and immune system attributes that mark pre-symptomatic disease states or protective resilience. By clarifying these early traits, the program aims to lay the groundwork for primary prevention strategies, meaning interventions designed to prevent chronic lung diseases from developing in the first place.
This opportunity uses the NIH R01 mechanism, which generally supports hypothesis-driven research projects and can fund substantial, multi-year investigations. The activity category is health, and it falls under CFDA 93.838 (Lung Diseases Research). The NIH emphasizes prospective definition and validation, which typically implies studies that follow individuals over time, measure relevant lung and immune characteristics, and then determine which attributes predict later disease onset versus continued health. The scope is anchored in lung health and disease broadly, and the objective is practical as well as scientific: generate the kind of early markers and mechanistic understanding that can inform prevention approaches for chronic lung disorders.
Eligibility is broad and includes many types of U.S. and non-U.S. entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3), including those other than universities), for-profit organizations (other than small businesses), small businesses, and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, and public housing authorities/Indian housing authorities. The FOA also explicitly includes tribal entities (federally recognized tribal governments and other tribal organizations), independent school districts, and regional organizations. In addition, the NIH lists multiple institution types and community-based categories as eligible, including faith-based or community-based organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs). Importantly, foreign participation is allowed: non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations may apply, and foreign components are allowed as defined under NIH policy.
The program does not require cost sharing or matching funds, which means applicants are not obligated to provide non-federal dollars as a condition of receiving the award. The announcement was posted and created on October 3, 2014, with an original and current closing date of January 21, 2015, and an archive date of February 21, 2015, indicating the opportunity is no longer active but remains useful as a reference point for NIH priorities and how the Institute has framed prevention-oriented lung research.
Administration and oversight are through the National Institutes of Health. For applicants who had trouble accessing the announcement or navigating links, the contact route provided is the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV). The full announcement was hosted on the NIH grants site at the link provided in the notice (http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-15-024.html), which would have included the detailed scientific objectives, application instructions, review criteria, and any special requirements tied to measuring and validating resilience or pre-symptomatic disease markers in lung health.
Frequently Asked Questions (FAQs)
What is the funding opportunity RFA-HL-15-024?
RFA-HL-15-024 is an NIH funding opportunity titled "Definition of Resilience and Pre Symptomatic Disease in Lung Health and Disease (R01)." It is a discretionary research grant program focused on lung health and disease, with an emphasis on identifying early biological features that indicate either pre-symptomatic pathways to chronic lung disease or protective resilience despite exposures or risk factors.
What is the main purpose of this NIH program?
The program aims to move research "upstream" by supporting studies that define and/or validate early, measurable pulmonary and immune system attributes. The goal is to determine which attributes predict later onset of chronic lung disease before symptoms appear, and which attributes indicate resilience (continued health) even in the presence of risk factors. This knowledge is intended to support primary prevention strategies to stop chronic lung diseases from developing in the first place.
What does NIH mean by "resilience" in this opportunity?
Based on the opportunity description, resilience refers to a state in which a person remains healthy despite exposures or risk factors that might otherwise increase the likelihood of developing chronic lung disease. The research focus is on identifying measurable biological features (particularly in pulmonary and immune systems) that correlate with this protective outcome.
What does "pre-symptomatic disease" mean in the context of this FOA?
In this FOA, pre-symptomatic disease refers to early biological changes that occur before clinical symptoms of chronic lung disease appear. The studies supported are intended to identify early, measurable features that signal a person is on a trajectory toward chronic lung disease even though they do not yet have symptoms.
What kind of studies does this opportunity encourage?
The FOA emphasizes prospective definition and validation, which typically means research that follows individuals over time, measures relevant lung and immune characteristics, and evaluates which early attributes predict later disease onset versus continued health. The intent is not limited to describing established disease; it prioritizes early markers and traits that appear before symptoms.
What research areas are within scope?
The scope is anchored in lung health and disease broadly, with particular attention to pulmonary and immune system attributes that can mark pre-symptomatic disease states or protective resilience. The overall objective is to generate early markers and mechanistic understanding that can inform prevention approaches for chronic lung disorders.
What is the funding mechanism used for this opportunity?
This opportunity uses the NIH R01 mechanism. The R01 is generally used to support hypothesis-driven research projects and can fund substantial, multi-year investigations.
What is the activity category and CFDA number for this program?
The activity category is health. The program is listed under CFDA 93.838 (Lung Diseases Research).
Who is eligible to apply?
Eligibility is broad and includes many U.S. and non-U.S. entities. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both 501(c)(3) and non-501(c)(3), including those other than universities), for-profit organizations (other than small businesses), small businesses, and a wide range of government entities.
Which government entities are eligible?
The FOA lists multiple government entities as eligible applicants, including state governments, county governments, city or township governments, special district governments, and public housing authorities/Indian housing authorities. It also includes independent school districts and regional organizations.
Are tribal entities eligible to apply?
Yes. The FOA explicitly includes tribal entities, including federally recognized tribal governments and other tribal organizations.
Are community-based or faith-based organizations eligible?
Yes. The eligibility list explicitly includes faith-based or community-based organizations among eligible institution types and categories.
Are minority-serving institutions specifically included as eligible applicants?
Yes. The FOA explicitly includes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs).
Is foreign participation allowed?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply. In addition, non-U.S. components of U.S. organizations may apply, and foreign components are allowed as defined under NIH policy.
Does this grant require cost sharing or matching funds?
No. The program does not require cost sharing or matching funds. Applicants are not obligated to provide non-federal dollars as a condition of receiving an award.
Is this funding opportunity still open?
No. The opportunity is no longer active. It was posted and created on October 3, 2014, with a closing date of January 21, 2015. The archive date is February 21, 2015.
Why might this archived FOA still be useful?
Even though it is closed, it can still serve as a reference point for NIH priorities and how NIH framed prevention-oriented lung research focused on early markers of pre-symptomatic disease and resilience.
Who administered and oversaw this funding opportunity?
The opportunity was administered and overseen by the National Institutes of Health (NIH).
Where could applicants find the full announcement details?
The full announcement was hosted on the NIH grants site at: http://grants.nih.gov/grants/guide/rfa-files/RFA-HL-15-024.html. The full posting would have included detailed scientific objectives, application instructions, review criteria, and any special requirements.
Who could be contacted for access or website/navigation issues related to the announcement?
The contact route provided for applicants who had trouble accessing the announcement or navigating links was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the practical outcome NIH is aiming for with this research?
The practical aim is to produce early markers and mechanistic understanding that can inform primary prevention strategies, meaning interventions designed to prevent chronic lung diseases from developing rather than treating established disease.
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