Opportunity Information: Apply for PA 12 107
Apply for PA 12 107
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Delivering Therapeutics to Residual Active HIV Reservoirs (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Oct 19, 2012 and posted on Feb 15, 2012.
- Applicants must submit their applications by Jan 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments County governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Small businesses State governments Private institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Delivering Therapeutics to Residual Active HIV Reservoirs (R01) (Funding Opportunity Number PA-12-107) is a National Institutes of Health (NIH) research grant opportunity focused on one of the central barriers to an HIV cure: cellular reservoirs that remain active in certain tissue compartments even when standard antiretroviral therapy (ART) has successfully suppressed HIV levels in the blood. The announcement is aimed at stimulating fresh, high-impact ideas that can reach and control (and ideally help eliminate) these residual pockets of ongoing virus production. The core problem being targeted is that plasma viral suppression does not necessarily mean HIV is fully shut down throughout the body, and persistent virus production in tissues can continue to drive immune activation and inflammation, while maintaining infected cells that are difficult to clear.
The scientific emphasis is on developing and testing new strategies to deliver ART or other anti-HIV agents more effectively into the anatomical sites and cellular niches where residual virus persists. In practical terms, this means proposals could focus on improved drug delivery technologies, tissue-penetrating formulations, targeted delivery to specific cell types, or other approaches that enhance local drug concentrations in hard-to-reach compartments. The intent is not only to stop ongoing viral production at these sites, but also to reduce downstream inflammation and create conditions that help the immune system (or other interventions) clear infected reservoir cells. Overall, the opportunity encourages research that bridges HIV reservoir biology with pharmacology, bioengineering, drug delivery, and immunologic clearance mechanisms.
This is an R01 mechanism, meaning it supports investigator-initiated, hypothesis-driven research projects that are typically multi-year and substantial in scope compared with smaller exploratory awards. The funding instrument type is a grant, and the activity category falls under health research. The program is associated with multiple CFDA numbers that reflect NIH research domains connected to the topic, including 93.855 (Allergy and Infectious Diseases Research), 93.856 (Microbiology and Infectious Diseases Research), and 93.242 (Mental Health Research Grants), indicating that relevant applications may span infectious disease, microbiology, immunology, and related health impacts.
The opportunity is categorized as discretionary funding, and it does not require cost sharing or matching funds. The announcement was posted on February 15, 2012, with an original closing date listed as January 7, 2015; however, the record also shows a current closing date of January 7, 2013, and an archive date of February 7, 2013, meaning the announcement is no longer active and is retained for historical reference.
Eligibility is broad and includes a wide range of domestic U.S. organizations and government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities, as well as academic institutions (both private and public/state-controlled institutions of higher education). It also includes nonprofits with or without 501(c)(3) status (with the noted exclusions around institutions of higher education depending on category) and for-profit organizations, including small businesses. Importantly, the FOA also allows participation by tribal entities (including federally recognized tribal governments and other tribal organizations), as well as a range of mission-focused institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. International participation is explicitly permitted: non-U.S. (foreign) institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined in the NIH Grants Policy Statement.
For applicants or interested parties seeking the official details, NIH provided an additional information link to the full announcement page (http://grants.nih.gov/grants/guide/pa-files/PA-12-107.html). The contact information in the listing points to the NIH Office of Extramural Research (OER) webmaster for technical issues accessing or linking to the announcement (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs)
1) What is the name of this grant opportunity?
The opportunity is titled Delivering Therapeutics to Residual Active HIV Reservoirs (R01).
2) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-12-107.
3) Which agency is offering this opportunity?
This is an opportunity from the National Institutes of Health (NIH).
4) What problem is this FOA trying to solve?
The FOA targets a major barrier to curing HIV: residual, active HIV reservoirs in certain tissue compartments that can remain active even when standard antiretroviral therapy (ART) has suppressed HIV in the blood (plasma viral suppression). These residual sites can continue producing virus, drive immune activation and inflammation, and maintain infected cells that are hard to eliminate.
5) Why is plasma viral suppression not enough, according to the FOA description?
The description emphasizes that suppressed HIV levels in the blood do not necessarily mean HIV is fully shut down throughout the body. Persistent virus production can continue in tissues, contributing to inflammation and sustaining infected reservoir cells.
6) What is the primary scientific focus of the research encouraged by this FOA?
The scientific emphasis is on developing and testing new strategies to deliver ART or other anti-HIV agents more effectively into anatomical sites and cellular niches where residual virus persists.
7) What kinds of approaches or project ideas fit this FOA?
Examples mentioned or implied by the description include:
- Improved drug delivery technologies
- Tissue-penetrating formulations that increase local drug exposure in hard-to-reach compartments
- Targeted delivery to specific cell types that harbor residual virus
- Other strategies that enhance local drug concentrations in relevant anatomical compartments
8) Is this FOA only about stopping viral replication, or does it also relate to inflammation and immune effects?
It is not limited to stopping viral replication. The intent also includes reducing downstream inflammation and creating conditions that could help the immune system (or other interventions) clear infected reservoir cells.
9) What research areas does this FOA aim to bridge?
The FOA encourages research that bridges HIV reservoir biology with fields such as pharmacology, bioengineering, drug delivery, and immunologic clearance mechanisms.
10) What type of award mechanism is this?
This is an R01 mechanism.
11) What does the R01 mechanism imply about the project style or scope?
Based on the description provided, an R01 supports investigator-initiated, hypothesis-driven research that is typically multi-year and substantial in scope compared with smaller exploratory awards.
12) What is the funding instrument type and activity category?
The funding instrument type is a grant, and the activity category is health research.
13) Is this a discretionary funding opportunity?
Yes. The opportunity is categorized as discretionary funding.
14) Is cost sharing or matching required?
No. The listing states that cost sharing/matching is not required.
15) Which CFDA numbers are associated with this opportunity?
The program is associated with multiple CFDA numbers, including:
- 93.855 (Allergy and Infectious Diseases Research)
- 93.856 (Microbiology and Infectious Diseases Research)
- 93.242 (Mental Health Research Grants)
These CFDA numbers indicate the topic can span infectious disease, microbiology, immunology, and related health impacts.
16) When was the FOA posted?
The announcement was posted on February 15, 2012.
17) What are the closing date(s) shown in the record?
The record shows multiple dates: an original closing date listed as January 7, 2015, a current closing date shown as January 7, 2013, and an archive date of February 7, 2013.
18) Is this FOA currently active?
No. The record indicates the announcement is no longer active and is retained for historical reference (with an archive date of February 7, 2013).
19) Who is eligible to apply?
Eligibility is described as broad and includes many organization types, such as:
- Domestic U.S. government entities (for example: state, county, city or township governments; special district governments; independent school districts; public housing authorities)
- Academic institutions (both private and public/state-controlled institutions of higher education)
- Nonprofits (with or without 501(c)(3) status, with noted category exclusions around institutions of higher education depending on classification)
- For-profit organizations, including small businesses
- Tribal entities (including federally recognized tribal governments and other tribal organizations)
- Mission-focused and designated institutions (such as HBCUs, Hispanic-serving institutions, TCCUs, Alaska Native and Native Hawaiian Serving Institutions)
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
20) Are international (non-U.S.) applicants allowed?
Yes. International participation is explicitly permitted: non-U.S. (foreign) institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined in the NIH Grants Policy Statement.
21) Where can applicants find the official FOA details?
The additional information link provided is: http://grants.nih.gov/grants/guide/pa-files/PA-12-107.html
22) Who should be contacted for technical issues accessing or linking to the announcement?
The contact listed for technical issues is the NIH Office of Extramural Research (OER) webmaster: FBOWebmaster@OD.NIH.GOV.
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