Opportunity Information: Apply for PAR 13 190
Apply for PAR 13 190
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Detection of Pathogen Induced Cancer (DPIC) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394 Cancer Detection and Diagnosis Research.
- This funding opportunity was created on Apr 11, 2013 and posted on Apr 11, 2013.
- Applicants must submit their applications by Dec 11, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Private institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education For profit organizations other than small businesses County governments State governments Independent school districts City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Detection of Pathogen Induced Cancer (DPIC) (R01) funding opportunity (PAR-13-190) is a National Cancer Institute (NCI) grant announcement under the National Institutes of Health (NIH) that supports investigator-initiated research aimed at improving how cancers caused or promoted by infectious agents are detected. The central scientific emphasis is on understanding and leveraging the interactions among carcinogenic pathogens, the human microbiome, and the host, with the practical goal of identifying measurable signals that can indicate risk or very early-stage disease. In other words, the FOA is looking for R01-level projects that can connect mechanistic biology and biomarkers to better tools or strategies for early detection, particularly in settings where infection-driven processes and long-term inflammation contribute to cancer development.
A key theme of the announcement is the idea that pathogen-induced cancers often arise through a multi-step process in which infection, shifts in the local or systemic microbiome, and host immune and inflammatory responses interact over time. Because chronic inflammation is frequently a bridge between persistent infection and eventual invasive cancer, the FOA explicitly encourages studies that examine chronic inflammation as part of the progression pathway and that seek molecular signatures tied to both risk and early detection. Projects responsive to this FOA would typically focus on identifying, validating, or refining molecular or microbial signatures that appear before cancer becomes clinically obvious, or that distinguish benign infection-related changes from those likely to progress to invasive malignancy.
The research scope, as described, is intentionally broad within that detection-focused framework. Applicants are encouraged to study “molecular signatures†associated with risk and early detection, which can include host-derived markers (such as immune or inflammatory pathways, genomic or epigenomic alterations, transcriptomic or proteomic patterns) as well as pathogen- and microbiome-associated features (such as pathogen strain factors, microbial community composition or function, and host-microbe interaction signals). The unifying expectation is that the project will deepen understanding of pathogen-microbiome-host dynamics in carcinogenesis and translate that understanding into detectable indicators relevant to early cancer interception or risk stratification.
Administratively, this opportunity uses the R01 mechanism, meaning it is designed for substantial, hypothesis-driven research projects with enough scope to support comprehensive studies, including discovery, assay development, and appropriate validation activities depending on the proposed aims. The FOA is categorized as discretionary funding and is aligned with the NIH activity area of health, specifically under CFDA 93.394 (Cancer Detection and Diagnosis Research). It does not require cost sharing or matching, which lowers barriers for a wide range of institutions.
Eligibility is expansive. Domestic applicants can include higher-education institutions (public, state-controlled, and private), nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits outside higher education), for-profit organizations (including small businesses and other for-profits), and multiple levels of government entities (state, county, city/township, special district governments), as well as public housing authorities/Indian housing authorities and independent school districts. The FOA also makes clear that a wide array of mission-serving institutions and community-based entities are eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, AANAPISIs, and tribally controlled colleges and universities (TCCUs), along with tribal governments and tribal organizations (including certain categories beyond federally recognized tribes as specified). Importantly, non-U.S. entities are eligible to apply: foreign organizations and foreign institutions may submit applications, and foreign components of U.S. organizations are allowed consistent with the NIH Grants Policy Statement. U.S. territories or possessions and regional organizations are also listed as eligible applicants.
In terms of timing and lifecycle, the FOA was posted and created on April 11, 2013, with an original and final closing date of December 11, 2015, and an archive date of January 11, 2016. The announcement also provides a link to the full FOA text on the NIH grants site (http://grants.nih.gov/grants/guide/pa-files/PAR-13-190.html), and it lists NIH Office of Extramural Research (OER) webmaster contacts for technical issues accessing the posting or linking to it.
Taken together, PAR-13-190 is essentially a call for rigorous detection-oriented cancer research that treats infection-driven carcinogenesis as a systems problem involving pathogens, the broader microbiome, and host biology. The strongest fits are projects that can credibly connect those interactions to practical molecular signatures for predicting risk, detecting cancer early, or identifying inflammatory trajectories that signal progression toward invasive disease.
Detection of Pathogen Induced Cancer (DPIC) (R01) - PAR-13-190 FAQs
What is the DPIC (R01) funding opportunity (PAR-13-190)?
PAR-13-190 is a National Cancer Institute (NCI) funding opportunity under the National Institutes of Health (NIH) that supports investigator-initiated R01 research focused on improving detection of cancers that are caused or promoted by infectious agents.
What is the main goal of this FOA?
The main goal is to advance early detection and risk indication for pathogen-induced cancers by identifying measurable signals (molecular, microbial, and host-related) that can indicate risk or very early-stage disease, especially where infection and long-term inflammation contribute to cancer development.
What types of cancers or cancer processes does this FOA emphasize?
The FOA emphasizes cancers linked to infectious agents and the multi-step progression processes in which infection, microbiome changes, and host immune/inflammatory responses interact over time to promote carcinogenesis.
How does chronic inflammation fit into the research scope?
Chronic inflammation is explicitly encouraged as a focus because it is frequently a bridge between persistent infection and eventual invasive cancer. The FOA encourages studies that examine chronic inflammation in progression pathways and that seek molecular signatures tied to both risk and early detection.
What does the FOA mean by "pathogen-microbiome-host dynamics"?
It refers to the interacting biological system formed by carcinogenic pathogens, the broader human microbiome, and the host (including immune and inflammatory responses). The FOA is interested in understanding these interactions and leveraging them to produce detectable indicators relevant to early cancer interception or risk stratification.
What kinds of "molecular signatures" are relevant to this FOA?
The FOA describes a broad set of possible molecular signatures associated with risk and early detection, including host-derived markers (for example, immune or inflammatory pathways, genomic or epigenomic alterations, transcriptomic patterns, or proteomic patterns) and pathogen- or microbiome-associated features (for example, pathogen strain factors, microbial community composition or function, and host-microbe interaction signals).
Does the FOA support biomarker discovery only, or also validation and refinement?
The FOA anticipates projects that can identify, validate, or refine signatures that appear before cancer is clinically obvious, or that distinguish benign infection-related changes from changes likely to progress to invasive malignancy. R01-level scope can support discovery, assay development, and appropriate validation activities depending on the proposed aims.
What kind of projects are considered a strong fit for PAR-13-190?
Projects that credibly connect mechanistic biology and biomarkers to practical tools or strategies for early detection are the strongest fits, particularly where infection-driven processes and long-term inflammation contribute to cancer development. Responsive projects typically deepen understanding of pathogen-microbiome-host interactions and translate that understanding into detectable indicators for early detection or risk stratification.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism, which is intended for substantial, hypothesis-driven research projects with enough scope to support comprehensive studies.
Which NIH institute is associated with this FOA?
The funding opportunity is associated with the National Cancer Institute (NCI) under NIH.
Is this considered a health-related funding opportunity?
Yes. It is aligned with the NIH activity area of health and is listed under CFDA 93.394 (Cancer Detection and Diagnosis Research).
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
Who is eligible to apply (in general terms)?
Eligibility is expansive and includes a wide range of domestic organizations (academia, nonprofits, for-profits, and government entities) as well as foreign organizations and foreign institutions. Foreign components of U.S. organizations are also allowed, consistent with the NIH Grants Policy Statement.
Are universities and colleges eligible applicants?
Yes. Eligible applicants include higher-education institutions, including public/state-controlled institutions and private institutions.
Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofit organizations, including 501(c)(3) nonprofits and certain non-501(c)(3) nonprofits outside of higher education.
Are for-profit entities eligible?
Yes. Eligible applicants include for-profit organizations, including small businesses and other for-profit entities.
Are government entities eligible to apply?
Yes. Eligible applicants include multiple levels of government entities such as state, county, and city/township governments, as well as special district governments.
Are public housing authorities or independent school districts eligible?
Yes. The eligibility list includes public housing authorities/Indian housing authorities and independent school districts.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The FOA explicitly lists a range of mission-serving institutions as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), and tribally controlled colleges and universities (TCCUs).
Are tribal governments and tribal organizations eligible?
Yes. The FOA includes tribal governments and tribal organizations as eligible applicants, including certain categories beyond federally recognized tribes as specified in the eligibility language.
Can non-U.S. organizations apply?
Yes. Foreign organizations and foreign institutions may submit applications, and foreign components of U.S. organizations are allowed consistent with NIH policy.
Are U.S. territories or regional organizations eligible?
Yes. U.S. territories or possessions and regional organizations are listed among eligible applicants.
When was PAR-13-190 posted and when did it close?
The FOA was posted and created on April 11, 2013. It had an original and final closing date of December 11, 2015, and an archive date of January 11, 2016.
Is this funding opportunity still open?
No. Based on the listed final closing date (December 11, 2015) and archive date (January 11, 2016), PAR-13-190 is no longer open.
Where can the full FOA text be found?
The announcement provides the full FOA link on the NIH grants site: http://grants.nih.gov/grants/guide/pa-files/PAR-13-190.html
Who should be contacted for technical issues accessing the FOA posting?
The announcement lists NIH Office of Extramural Research (OER) webmaster contacts for technical issues related to accessing the posting or linking to it.
What distinguishes this FOA from general cancer detection research?
This FOA is specifically detection-oriented within the context of infection-driven carcinogenesis, emphasizing systems-level interactions among carcinogenic pathogens, the microbiome, and host biology, with a practical focus on measurable signatures that indicate risk or very early-stage disease.
What is meant by "early cancer interception" in this context?
Within the FOA description, early cancer interception refers to using detectable indicators (such as molecular or microbial signatures) that appear early enough to inform risk stratification or identify disease at very early stages, before cancer becomes clinically obvious.
Does the FOA encourage research that differentiates benign infection-related changes from likely progression to cancer?
Yes. The FOA highlights projects that can distinguish benign infection-related changes from those likely to progress to invasive malignancy.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 13 190) also looked into and applied for these:
| Funding Opportunity |
|---|
| Revision Applications to U01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (U01) Apply for PAR 13 176 Funding Number: PAR 13 176 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Imaging and Biomarkers for Early Cancer Detection (R01) Apply for PAR 13 189 Funding Number: PAR 13 189 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Revision Applications to R01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (R01) Apply for PAR 13 177 Funding Number: PAR 13 177 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revision Applications to P50 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P50) Apply for PAR 13 174 Funding Number: PAR 13 174 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revision Applications to R01 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (R01) Apply for PAR 13 172 Funding Number: PAR 13 172 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revision Applications to U01 Awards on Detection of Pathogen Induced Cancer (DPIC) (U01) Apply for PAR 13 173 Funding Number: PAR 13 173 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revision Applications to P01 Awards for Research on Imaging and Biomarkers for Early Cancer Detection (P01) Apply for PAR 13 175 Funding Number: PAR 13 175 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revisions to P50 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (P50) Apply for PAR 13 170 Funding Number: PAR 13 170 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Revisions to P01 Awards for Research on Detection of Pathogen Induced Cancer (DPIC) (P01) Apply for PAR 13 171 Funding Number: PAR 13 171 Agency: National Institutes of Health Category: Education Health Funding Amount: $150,000 |
| Paul Calabresi Career Development Award for Clinical Oncology (K12) Apply for PAR 13 201 Funding Number: PAR 13 201 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Symptom Management in HIV Infected Individuals with Comorbid Conditions (R01) Apply for PA 13 210 Funding Number: PA 13 210 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Symptom Management in HIV Infected Individuals with Comorbid Conditions (R21) Apply for PA 13 211 Funding Number: PA 13 211 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Innovative Measurement Tools for Community Engaged Research Efforts (R01) Apply for PA 13 209 Funding Number: PA 13 209 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Innovative Measurement Tools for Community Engaged Research Efforts (R21) Apply for PA 13 212 Funding Number: PA 13 212 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Limited Competition Fogarty HIV Research Training Program for Low and Middle Income Country Institutions (D43) Apply for PAR 13 126 Funding Number: PAR 13 126 Agency: National Institutes of Health Category: Education Health Funding Amount: $282,000 |
| Medications Development Centers of Excellence Cooperative Program (U54) Apply for RFA DA 14 004 Funding Number: RFA DA 14 004 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,000,000 |
| Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R01) Apply for RFA DA 14 005 Funding Number: RFA DA 14 005 Agency: National Institutes of Health Category: Education Health Funding Amount: $350,000 |
| Substance Use Disorders and Molecular Regulation of Brain Energy Utilization (R21) Apply for RFA DA 14 006 Funding Number: RFA DA 14 006 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Integration and Analysis of Diverse HIV Associated Data (R03) Apply for RFA MH 14 200 Funding Number: RFA MH 14 200 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NIDA Research Center of Excellence Grant Program (P50) Apply for PAR 13 222 Funding Number: PAR 13 222 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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