Opportunity Information: Apply for RFA RM 09 016
Apply for RFA RM 09 016
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Developing Technologies for Improved In Vivo Epigenetic Imaging or Analysis (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Dec 3, 2009 and posted on Dec 3, 2009.
- Applicants must submit their applications by Feb 3, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Independent school districts Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments Public housing authorities/Indian housing authorities State governments Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The National Institutes of Health (NIH) funding opportunity announcement (FOA) titled "Developing Technologies for Improved In Vivo Epigenetic Imaging or Analysis (R01)" (Funding Opportunity Number RFA-RM-09-016) was a discretionary grant program aimed at pushing the field of epigenetics beyond conventional laboratory assays and toward tools that can work in living systems. The central goal was to support the creation of genuinely new, high-impact technologies that make it possible to image or otherwise analyze epigenetic changes in vivo, meaning in intact living cells, tissues, or organisms rather than only in extracted samples. In practical terms, the FOA was looking for proposals that could open up new ways to track how epigenetic regulation changes over time and space in living biology, which is important for understanding development, aging, and disease processes that involve dynamic chromatin regulation.
Scientifically, the FOA emphasized technology development focused on epigenetic features such as epigenetic marks themselves (for example, chemical modifications associated with DNA or histones), the enzymes that place or remove those marks (modifying enzymes), the molecules that interpret or respond to those marks (effector molecules), and the activities of these molecular players. It also included broader measures of chromatin state, which could encompass structural or functional readouts that reflect how chromatin is organized and how accessible genes are within living cells. The intent was not simply incremental improvement of existing assays, but rather the development of transformative approaches that could enable real-time, spatially resolved, or otherwise improved observation and measurement of epigenetic phenomena in vivo.
The mechanism of support was the NIH R01, a standard research project grant intended to fund well-defined research and development plans. This implies that applicants were expected to present a rigorous project with clear milestones, feasible technical strategies, and strong justification for why the proposed technology would represent a meaningful leap forward for in vivo epigenetic imaging or analysis. As an R01, the program was positioned to support substantial research efforts rather than small pilot studies, aligning with the FOA's emphasis on "revolutionary" technology development.
In terms of funding, NIH committed an estimated total of $3.5 million in Fiscal Year 2010 to support this program. The FOA anticipated making approximately 7 to 10 awards, with the final number dependent on two factors: the availability of appropriated funds and whether enough high-quality, competitive (meritorious) applications were received. This kind of language is typical for NIH announcements and signals that funding levels and award counts are projections rather than guarantees.
Eligibility was broad and included many types of organizations. Eligible applicants listed in the notice included federal, state, county, city or township governments, special district governments, public housing authorities/Indian housing authorities, and independent school districts. Academic institutions were eligible, including public and state-controlled institutions of higher education and private institutions of higher education. The FOA also allowed applications from nonprofit organizations, both those with 501(c)(3) status and those without 501(c)(3) status (in both cases, other than institutions of higher education). For-profit organizations were eligible as well, including small businesses and other for-profit entities that are not small businesses. The FOA also explicitly broadened eligibility to include a range of mission-driven and underrepresented institution types and communities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and other tribal organizations, including both federally recognized tribal governments and other Indian/Native American tribal governments. Faith-based and community-based organizations were named as eligible, along with U.S. territories or possessions, regional organizations, eligible federal agencies, and non-U.S. entities (foreign organizations), indicating the program was open to international participation as well.
Administratively, the FOA was posted on December 3, 2009, and had an original (and final) closing date of February 3, 2010, with an archive date of March 6, 2010. The program was categorized under health-related funding activity and tied to CFDA number 93.310 (Trans-NIH Research Support). There was no cost-sharing or matching requirement, meaning applicants were not required to provide matching funds as a condition of eligibility or award. For applicants needing assistance accessing the full announcement or having technical issues with the posting, the notice provided contact details for the NIH Office of Extramural Research (OER) webmaster.
Overall, this opportunity was designed to catalyze the development of next-generation tools that would allow researchers to observe and measure epigenetic regulation as it happens in living systems, with the expectation that such tools could reshape how epigenetic mechanisms are studied across biology and medicine.
Frequently Asked Questions (FAQs)
What is the name of this NIH funding opportunity?
The funding opportunity announcement (FOA) is titled "Developing Technologies for Improved In Vivo Epigenetic Imaging or Analysis (R01)."
What is the funding opportunity number?
The Funding Opportunity Number is RFA-RM-09-016.
What type of program was this?
This was an NIH discretionary grant program focused on technology development for in vivo epigenetic imaging or analysis.
What does "in vivo" mean in the context of this FOA?
In this FOA, "in vivo" refers to measuring or imaging epigenetic changes in intact living cells, tissues, or organisms, rather than relying only on extracted samples or conventional laboratory assays.
What was the main goal of the FOA?
The central goal was to support the creation of genuinely new, high-impact technologies that enable epigenetic imaging or other epigenetic analysis in living systems, helping researchers track changes over time and space.
What kinds of scientific advances was NIH trying to catalyze here?
The FOA aimed to push the field of epigenetics beyond conventional assays and toward transformative tools that can observe epigenetic regulation dynamically within living biology.
Why is in vivo epigenetic imaging or analysis considered important?
The FOA highlighted that being able to track epigenetic regulation in living systems is important for understanding development, aging, and disease processes where chromatin regulation changes over time and varies by location within tissues.
What specific epigenetic features were emphasized as targets for technology development?
The FOA emphasized technologies focused on epigenetic marks (such as chemical modifications associated with DNA or histones), the enzymes that add or remove those marks (modifying enzymes), effector molecules that interpret or respond to marks, and the activities of these molecular players.
Did the FOA include chromatin-level measurements beyond individual marks?
Yes. It also included broader measures of chromatin state, including structural or functional readouts that reflect chromatin organization and gene accessibility in living cells.
Was NIH looking for incremental improvements to existing assays?
No. The FOA explicitly emphasized transformative, high-impact approaches rather than simple incremental improvements of existing methods.
What grant mechanism was used?
The mechanism of support was the NIH R01 research project grant.
What does using an R01 mechanism imply about the expected project scope?
It implies applicants were expected to propose a well-defined research and development plan with rigorous justification, feasible technical strategies, and clear milestones, suitable for a substantial research effort rather than a small pilot study.
How much total funding did NIH estimate for this program?
NIH committed an estimated total of $3.5 million in Fiscal Year 2010 for this FOA.
How many awards were anticipated?
The FOA anticipated approximately 7 to 10 awards.
Was the number of awards guaranteed?
No. The FOA stated that the final number of awards depended on the availability of appropriated funds and the receipt of a sufficient number of meritorious applications.
Who was eligible to apply?
Eligibility was broad and included many organization types, including various levels of government, academic institutions, nonprofits, for-profits, eligible federal agencies, and non-U.S. entities (foreign organizations).
Were government organizations eligible applicants?
Yes. Eligible applicants included federal, state, county, city or township governments, special district governments, public housing authorities/Indian housing authorities, and independent school districts.
Were colleges and universities eligible?
Yes. Both public/state-controlled institutions of higher education and private institutions of higher education were eligible.
Could nonprofit organizations apply?
Yes. Nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (in both cases, other than institutions of higher education) were listed as eligible.
Could for-profit organizations apply?
Yes. For-profit organizations were eligible, including small businesses and other for-profit entities that are not small businesses.
Were Historically Black Colleges and Universities (HBCUs) and other designated institution types included?
Yes. The FOA explicitly included HBCUs, Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and other tribal organizations.
Were tribal governments or other tribal entities eligible?
Yes. The FOA included federally recognized tribal governments and other Indian/Native American tribal governments, as well as other tribal organizations.
Were faith-based or community-based organizations eligible?
Yes. Faith-based and community-based organizations were named as eligible.
Were U.S. territories or possessions eligible?
Yes. U.S. territories or possessions were listed as eligible applicants.
Were regional organizations eligible?
Yes. Regional organizations were included in the list of eligible applicants.
Could foreign (non-U.S.) organizations apply?
Yes. The FOA stated that non-U.S. entities (foreign organizations) were eligible, indicating international participation was allowed.
Was there a cost-sharing or matching requirement?
No. The FOA indicated there was no cost-sharing or matching requirement.
When was the FOA posted?
The FOA was posted on December 3, 2009.
What was the application due date?
The FOA had an original (and final) closing date of February 3, 2010.
When was the FOA archived?
The archive date was March 6, 2010.
What funding activity category did this fall under?
The program was categorized under a health-related funding activity.
What CFDA number was associated with this opportunity?
The CFDA number listed was 93.310 (Trans-NIH Research Support).
What kind of support contact was provided for technical issues?
The FOA provided contact details for the NIH Office of Extramural Research (OER) webmaster for assistance accessing the full announcement or resolving technical issues with the posting.
What overall impact was this opportunity intended to have?
The FOA was designed to catalyze next-generation tools for observing and measuring epigenetic regulation as it happens in living systems, with the expectation that these tools could reshape how epigenetic mechanisms are studied across biology and medicine.
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