Developing the Therapeutic Potential of the Endocannabinoid System for Pain Treatment (R01) | Apply Online

Opportunity Summary:

Developing the Therapeutic Potential of the Endocannabinoid System for Pain Treatment (R01) is an NIH research grant opportunity (Funding Opportunity Number PA 15 188) focused on advancing pain treatments by studying cannabinoids and the body s own endocannabinoid system. The main goal is to fund mechanistic, hypothesis driven projects that clarify how cannabinoid related pathways influence pain signaling and pain modulation, with the larger intent of translating that knowledge into mechanism based therapies. In practice, this means the FOA is aimed at research that can explain what is happening biologically (for example, which receptors, signaling pathways, cell types, or neural circuits are involved) and how those findings can be leveraged to develop or refine therapeutic strategies for pain conditions.

The opportunity uses the R01 mechanism, which is NIH s standard grant program for investigator initiated research projects and typically supports well developed research plans that can be carried out over multiple years. It is categorized as a discretionary grant funding instrument, and it falls under broad public purpose areas that include education, health, and social services. The announcement ties to multiple NIH related CFDA program areas, reflecting the cross cutting nature of pain research and cannabinoid biology. Those CFDA numbers include complementary and integrative health research (93.213), alcohol research (93.273), drug abuse and addiction research (93.279), cancer cause and prevention research (93.393), neurosciences and neurological disorders extramural research (93.853), child health and human development research (93.865), and aging research (93.866). Taken together, that list signals that NIH viewed endocannabinoid based pain research as relevant to many disease areas and populations, including conditions where pain intersects with cancer, substance use, neurological disorders, development across the lifespan, and aging.

A notable feature of this FOA is its broad eligibility. Applicants could come from many organization types, including public and private institutions of higher education, nonprofits with or without 501(c)(3) status, for profit organizations (including small businesses), and a wide range of government entities such as state, county, city or township governments, independent school districts, special district governments, and public or Indian housing authorities. The eligibility language also explicitly includes tribal governments and tribal organizations, as well as a variety of mission focused institution types such as Historically Black Colleges and Universities, Hispanic Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions. In addition, it allows certain non U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, eligible federal agencies, and faith based or community based organizations, which indicates an intent to encourage participation from diverse research settings and communities.

From an administrative standpoint, the FOA did not require cost sharing or matching, which generally lowers barriers for applicants by not requiring them to contribute non federal funds to the project budget. The announcement was posted and created on April 28, 2015, with an original and final closing date of September 7, 2018, and it was archived on October 8, 2018. That timeline means it was a time limited NIH program announcement that accepted applications through that final due date window.

The sponsoring agency is the National Institutes of Health. The FOA emphasizes understanding therapeutic potential, which typically implies research that can identify promising molecular targets, validate mechanisms in relevant models, and establish the rationale for future intervention development. While the brief description does not list specific required topics, the framing around cannabinoids and the endocannabinoid system suggests projects could involve cannabinoid receptors and related signaling, endogenous cannabinoid ligands and their synthesis or breakdown, and how manipulating these components changes pain processing. The phrase mechanism based therapies is important because it implies NIH was looking for more than descriptive studies; it points toward work that can link biological mechanism to potential treatment approaches in a way that could eventually support translational development.

For further details, NIH provided an official link to the full announcement at http://grants.nih.gov/grants/guide/pa-files/PA-15-188.html. For access or technical issues with the electronic posting, the contact listed is the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV, including support for difficulties accessing the announcement or problems linking to it.

Browse more opportunities from the same agency: National Institutes of Health

Browse more opportunities from the same category: Education Health Income Security and Social Services

Next opportunity: Conservation Innovation Grant (CIG) FY15

Previous opportunity: DoD Multiple Sclerosis Pilot Clinical Trial Award

USGrants.org Applicant Portal:

Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.

Apply for PA 15 188

 

[Watch] how do funding administrators access proposals?

Applicants also applied for:

Applicants who have applied for this opportunity (PA 15 188) also looked into and applied for these:

 

Grant application guides and resources

It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!

Apply for Grants

 

 

Premium leads for funding administrators, grant writers, and loan issuers

Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.

If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.

Subscribe to Leads

 

Request more information:

Would you like to learn more about this funding opportunity, similar opportunities to "PA 15 188", eligibility, application service, and/or application tips? Submit an inquiry below:

Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.