Opportunity Information: Apply for RFA RM 12 019
Apply for RFA RM 12 019
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development and Application of Systems Approaches for Analyzing the Impact of Genomic Variation on Tissue Transcriptomes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Aug 7, 2012 and posted on Aug 7, 2012.
- Applicants must submit their applications by Nov 21, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Public housing authorities/Indian housing authorities Special district governments County governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Independent school districts State governments For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity titled "Development and Application of Systems Approaches for Analyzing the Impact of Genomic Variation on Tissue Transcriptomes (R01)" (Funding Opportunity Number RFA-RM-12-019) was a discretionary grant solicitation issued by the National Institutes of Health and supported through the NIH Common Fund. It called for investigator-initiated R01 research projects focused specifically on statistical and computational analysis of data produced by the Genotype-Tissue Expression (GTEx) program. The central purpose was not to generate new GTEx samples, but to create and apply advanced analytical methods that could extract as much biological and biomedical insight as possible from the GTEx resource.
GTEx was designed to answer a major challenge in human genetics: understanding how inherited genomic variation influences gene expression in real human tissues, and how those effects differ across tissue types. The FOA emphasized that GTEx would become an unusually large and valuable reference dataset, because it links genetic variant information from a large number of donors to gene expression measurements collected across many different tissue types from those same donors. The announcement projected that by 2016 the program would include genomic variation data from about 900 post-mortem donors and transcriptomic (gene expression) measurements from more than 20,000 tissue samples, creating a rich multi-tissue atlas for studying regulatory variation and tissue-specific gene regulation.
The research emphasis of the opportunity was on developing and applying "systems approaches" and statistical methodology suited to the complexity of GTEx data. In practical terms, this meant methods capable of handling multi-tissue expression profiles, donor-to-donor variability, complex regulatory architectures, and the high dimensional nature of genome-wide genotype and transcriptome data. Competitive applications would be expected to propose rigorous analytical strategies that could identify and interpret relationships between genetic variants and tissue-specific or shared expression patterns, improve the inference of regulatory mechanisms, and support integrative, network-level or pathway-level understanding rather than isolated single-gene findings. The FOA framed GTEx as a unique community resource and encouraged approaches that would maximize its utility for the broader biomedical research community.
From an administrative standpoint, the mechanism was an NIH R01 (a standard research project grant). The opportunity fell under the Health funding activity category and listed CFDA number 93.310 (Trans-NIH Research Support). Cost sharing or matching was not required. NIH posted the announcement on August 7, 2012, with an original and current closing date of November 21, 2012, and an archive date of December 22, 2012. The estimated total funding amount listed for the FOA was $3,000,000.
Eligibility was broad and included many types of U.S. and non-U.S. applicants. Eligible applicants included state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status; small businesses; and for-profit organizations other than small businesses. It also included tribal governments (both federally recognized and other than federally recognized), tribally controlled colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. Importantly, foreign institutions were eligible to apply, foreign components were allowed under NIH policy, and non-domestic components of U.S. organizations could participate, reflecting NIH's interest in drawing on the best available methodological expertise regardless of geography.
For applicants seeking the full details, the FOA provided an official link hosted on the NIH grants site (RFA-RM-12-019). The notice also included practical support contacts through the NIH Office of Extramural Research webmaster for access or linking issues. Overall, the opportunity was aimed at accelerating the development of sophisticated statistical and systems biology tools that could translate GTEx data into clearer, tissue-resolved insights about how human genetic variation shapes the transcriptome.
Frequently Asked Questions (FAQs)
What is the title of this NIH funding opportunity?
The funding opportunity is titled "Development and Application of Systems Approaches for Analyzing the Impact of Genomic Variation on Tissue Transcriptomes (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-RM-12-019.
Which agency issued and supported this opportunity?
This was a discretionary grant solicitation issued by the National Institutes of Health (NIH) and supported through the NIH Common Fund.
What grant mechanism does this opportunity use?
The mechanism is an NIH R01, which is NIH's standard research project grant mechanism.
What research program is this opportunity focused on?
The opportunity is focused on statistical and computational analysis of data produced by the Genotype-Tissue Expression (GTEx) program.
What is the central purpose of the FOA?
The central purpose is to create and apply advanced analytical methods that can extract as much biological and biomedical insight as possible from the GTEx resource.
Is the goal to generate new GTEx samples?
No. The FOA emphasized that the goal was not to generate new GTEx samples, but to develop and apply methods to analyze existing GTEx data.
What scientific problem is GTEx designed to address?
GTEx is designed to address the challenge of understanding how inherited genomic variation influences gene expression in real human tissues, and how those effects differ across tissue types.
Why did NIH describe GTEx as an unusually valuable reference dataset?
Because it links genetic variant information from a large number of donors to gene expression measurements collected across many different tissue types from those same donors, enabling multi-tissue analyses within the same individuals.
What scale of data did the FOA project for GTEx?
The FOA projected that by 2016 the program would include genomic variation data from about 900 post-mortem donors and transcriptomic (gene expression) measurements from more than 20,000 tissue samples.
What does the FOA mean by "systems approaches" in this context?
It refers to analytical and statistical approaches suited to complex, high-dimensional GTEx data, including methods that can handle multi-tissue expression profiles, donor-to-donor variability, and complex regulatory architectures, and that support integrative, network-level or pathway-level understanding.
What kinds of analytical methods or capabilities were emphasized?
The FOA emphasized methods capable of handling multi-tissue expression profiles, donor-to-donor variability, complex regulatory architectures, and the high-dimensional nature of genome-wide genotype and transcriptome data.
What types of biological insights were competitive applications expected to target?
Competitive applications were expected to propose rigorous strategies to identify and interpret relationships between genetic variants and tissue-specific or shared expression patterns, improve inference of regulatory mechanisms, and support integrative network-level or pathway-level understanding rather than isolated single-gene findings.
How did the FOA frame GTEx for the broader community?
The FOA framed GTEx as a unique community resource and encouraged approaches that would maximize its utility for the broader biomedical research community.
What funding activity category was listed?
The opportunity fell under the Health funding activity category.
What CFDA number was associated with this opportunity?
The listed CFDA number was 93.310 (Trans-NIH Research Support).
Was cost sharing or matching required?
No. Cost sharing or matching was not required.
How much total funding was estimated for this FOA?
The estimated total funding amount listed was $3,000,000.
When was this FOA posted?
NIH posted the announcement on August 7, 2012.
What were the application closing dates?
The original and current closing date listed was November 21, 2012.
When was the FOA archived?
The archive date was December 22, 2012.
Who was eligible to apply?
Eligibility was broad and included many U.S. and non-U.S. applicant types, including: state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with and without 501(c)(3) status; small businesses; for-profit organizations other than small businesses; tribal governments (federally recognized and other than federally recognized); tribally controlled colleges and universities; Alaska Native and Native Hawaiian Serving Institutions; Hispanic-serving institutions; Historically Black Colleges and Universities; faith-based and community-based organizations; regional organizations; U.S. territories or possessions; and eligible federal agencies.
Are foreign institutions eligible to apply?
Yes. Foreign institutions were eligible to apply.
Are foreign components allowed under this FOA?
Yes. Foreign components were allowed under NIH policy.
Can non-domestic components of U.S. organizations participate?
Yes. Non-domestic components of U.S. organizations could participate.
Where can applicants find the official FOA details?
The FOA provided an official link hosted on the NIH grants site for RFA-RM-12-019.
Who should be contacted for access or linking issues with the FOA?
The notice included practical support contacts through the NIH Office of Extramural Research webmaster for access or linking issues.
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