Opportunity Information: Apply for PA 10 014
Apply for PA 10 014
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development and Characterization of Animal Models for Aging Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866 Aging Research.
- This funding opportunity was created on Mar 22, 2013 and posted on Oct 28, 2009.
- Applicants must submit their applications by Mar 22, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH National Institute on Aging (NIA) funding opportunity PA 10 014, titled "Development and Characterization of Animal Models for Aging Research (R01)," is a discretionary grant program that supports research aimed at strengthening the tools researchers use to study aging. At its core, the opportunity is about building better model systems for aging science and making existing models more informative and useful. Although the title highlights animal models, the scope is broader and explicitly includes other model systems such as specialized cell lines and informatics resources that improve how aging-related animal data are generated, interpreted, shared, or reused.
This FOA invites R01 Research Project Grant applications that focus on developing, characterizing, refining, or otherwise enhancing models used in aging research. A major emphasis is on careful characterization of aging across multiple levels, including physiological changes (how organs and systems function over time), biochemical changes (molecular and metabolic shifts), and functional outcomes (performance, behavior, resilience, or other measurable age-related traits). NIA is interested both in deepening knowledge about models already used in aging studies and in adapting models from other research areas that may not traditionally be labeled as "aging models" but could offer strong value for aging biology once their age-related trajectories are mapped and validated.
Applicants are encouraged to propose several kinds of model-focused projects. One pathway is to improve or expand the understanding of existing animal models by documenting how aging manifests in them, establishing baselines, identifying biomarkers, and clarifying which endpoints best capture meaningful age-related decline or adaptation. Another pathway is the creation of new animal models specifically tailored to aging research, which could include novel strains, genetically modified organisms, or models optimized for particular aging phenotypes, comorbidities, or intervention testing. The FOA also supports the development of unique cell lines relevant to aging, which can be crucial for mechanistic studies, screening, or work that complements in vivo findings. In addition, NIA highlights comparative biology, meaning studies that compare across species or strains to determine which models are most promising or highest priority for particular aging questions. Finally, there is explicit interest in informatics approaches that make animal-based aging research more powerful, such as data platforms, standardized resources, or analytic tools that improve the utilization, integration, and comparability of aging model data.
In terms of funding mechanism, the program uses the NIH R01 award mechanism, which is generally intended for well-developed research projects with a substantial scientific plan and clear aims. This FOA is described as running in parallel with a separate announcement of the same scientific scope, PA 10 015, which uses the R21 Exploratory/Developmental Research Grant mechanism. In practice, that means NIA provided two aligned options: an R01 route for more established projects and an R21 route for earlier-stage or higher-risk exploratory work, while keeping the underlying scientific priorities consistent.
Awards are dependent on the availability of funds and on how many high-quality applications are submitted, and the announcement does not guarantee a set number of awards. The activity category is health-related, listed under CFDA 93.866 (Aging Research), and there is no cost-sharing or matching requirement.
Eligibility is broad and includes many organization types. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses), Native American tribal governments (federally recognized and other than federally recognized), and tribal organizations. The eligibility list also includes HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities, U.S. territories or possessions, regional organizations, and even non-U.S. entities (foreign organizations), indicating NIA intended the research community to have wide access to apply.
Key administrative details from the source data include a posted date of October 28, 2009, and an archived status after April 22, 2013, with the last listed closing date as March 22, 2013 (the original closing date noted as January 7, 2013). The primary agency is the National Institutes of Health, and the full announcement was hosted via the NIH grants guide. Contact notes in the listing direct technical access or linking issues to the NIH Office of Extramural Research (OER) webmaster email.
FAQs: NIH NIA PA-10-014 - Development and Characterization of Animal Models for Aging Research (R01)
What is PA-10-014?
PA-10-014 is a National Institutes of Health (NIH) National Institute on Aging (NIA) funding opportunity announcement titled "Development and Characterization of Animal Models for Aging Research (R01)." It supports research projects that develop, characterize, refine, or otherwise improve model systems used to study aging.
What is the main purpose of this funding opportunity?
The purpose is to strengthen the tools used in aging research by building better model systems and making existing models more informative, better characterized, and more useful for studying age-related biology and outcomes.
Is this opportunity limited to animal models only?
No. While the title highlights animal models, the scope explicitly includes other model systems such as specialized cell lines and informatics resources that improve how animal-based aging data are generated, interpreted, shared, or reused.
What types of projects does NIA want to fund under this announcement?
NIA invites R01 Research Project Grant applications focused on developing, characterizing, refining, or enhancing models used in aging research. Projects may include work on existing models, creation of new models, development of relevant cell lines, comparative biology across species/strains, and informatics resources that improve aging model research.
What does "characterization of aging" mean in the context of this FOA?
Characterization refers to carefully documenting how aging appears in a model across multiple levels, including physiological changes (organ/system function over time), biochemical changes (molecular/metabolic shifts), and functional outcomes (performance, behavior, resilience, or other measurable age-related traits).
Can applicants propose projects that deepen understanding of existing animal models?
Yes. One encouraged pathway is to improve or expand knowledge of established animal models by documenting age-related trajectories, establishing baselines, identifying biomarkers, and clarifying which endpoints best reflect meaningful age-related decline or adaptation.
Does the FOA support creating new animal models for aging research?
Yes. The FOA supports creation of new animal models specifically tailored to aging research, including novel strains, genetically modified organisms, or models optimized for specific aging phenotypes, comorbidities, or intervention testing.
Are cell lines within scope for PA-10-014?
Yes. NIA includes development of unique cell lines relevant to aging. These resources can support mechanistic studies, screening approaches, or complementary work alongside in vivo studies.
What is meant by "comparative biology" in this opportunity?
Comparative biology refers to studies that compare across species or strains to determine which models are most promising or highest priority for specific aging research questions.
Are informatics or data platform projects eligible?
Yes. The FOA explicitly notes interest in informatics approaches that make animal-based aging research more powerful, including data platforms, standardized resources, and analytic tools that improve utilization, integration, and comparability of aging model data.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 Research Project Grant mechanism, which is generally intended for well-developed research projects with a substantial scientific plan and clear aims.
Is there a related opportunity for exploratory or early-stage work?
Yes. PA-10-014 (R01) was described as running in parallel with PA-10-015, which covers the same scientific scope but uses the R21 Exploratory/Developmental Research Grant mechanism.
How do the R01 and R21 options differ according to the listing?
Based on the description provided, the R01 route is intended for more established projects, while the R21 route is intended for earlier-stage or higher-risk exploratory work, with underlying scientific priorities kept consistent.
Is a specific number of awards guaranteed?
No. The announcement indicates that awards depend on availability of funds and the number of high-quality applications received, and it does not guarantee a set number of awards.
Is there a cost-sharing or matching requirement?
No. The listing states there is no cost-sharing or matching requirement.
What is the activity category and CFDA number associated with this opportunity?
The activity category is health-related, and it is listed under CFDA 93.866 (Aging Research).
Who is eligible to apply?
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (including small businesses), Native American tribal governments (federally recognized and other than federally recognized), and tribal organizations.
Does the eligibility list include minority-serving institutions and tribal colleges?
Yes. The eligibility list includes HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities.
Are U.S. territories or regional organizations eligible?
Yes. The eligibility list includes U.S. territories or possessions and regional organizations.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility list includes non-U.S. entities (foreign organizations), indicating the opportunity was open to foreign applicants.
Which NIH institute is associated with this opportunity?
The primary NIH institute for this opportunity is the National Institute on Aging (NIA).
When was this funding opportunity posted?
The posted date listed is October 28, 2009.
Is this funding opportunity still open?
No. The listing indicates an archived status after April 22, 2013, and the last listed closing date is March 22, 2013 (with an original closing date noted as January 7, 2013).
Where was the full announcement hosted?
The full announcement was hosted via the NIH grants guide.
Who should be contacted for technical access or linking issues?
The listing directs technical access or linking issues to the NIH Office of Extramural Research (OER) webmaster email.
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