Opportunity Information: Apply for PA 13 156

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development and Characterization of Animal Models for Aging Research (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.866 Aging Research.
  • This funding opportunity was created on Mar 22, 2013 and posted on Mar 22, 2013.
  • Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: County governments Special district governments City or township governments Independent school districts Small businesses Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Private institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

Development and Characterization of Animal Models for Aging Research (R21) is a National Institutes of Health (NIH) funding opportunity (PA 13-156) designed to support early-stage, exploratory research projects that build better animal model systems for aging research. The central goal is to push the field forward by encouraging investigators to develop new models, or to improve and more thoroughly characterize existing models, so they are more informative for studying the biology of aging and age-related processes. In practical terms, the NIH is looking for projects that create, validate, refine, and enhance animal models in ways that make them more useful, reproducible, and relevant for research on aging mechanisms and the conditions that become more common with advancing age.

This announcement uses the R21 mechanism, which typically emphasizes innovation and feasibility rather than fully mature, long-term research programs. That makes it a good fit for ideas that are promising but still need foundational work, such as establishing a new model system, collecting key characterization data, or demonstrating proof-of-concept for how a refined model can answer aging-related scientific questions. The research focus is specifically on model systems for aging research, which may include (depending on the project) improving how aging phenotypes are measured, strengthening links between animal phenotypes and human aging biology, or increasing the model's utility through better genetic, behavioral, physiological, or pathological characterization. The overarching theme is that the models themselves are the target of development and improvement, rather than using a standard model only as a tool to pursue an unrelated hypothesis.

The opportunity is categorized as a discretionary grant in the health funding area, and it is connected to NIH program areas reflected by CFDA numbers 93.866 (Aging Research) and 93.173 (Research Related to Deafness and Communication Disorders). This suggests a primary alignment with aging research while also acknowledging that improved aging models can be relevant for specific age-associated functional domains, including communication and sensory systems, where age-related decline is common and where better models can clarify biological mechanisms and potential interventions.

Eligibility is broad and includes a wide range of U.S. public and private entities as well as international organizations. Eligible applicants include state and local governments (such as county governments, city or township governments, and special district governments), public and state-controlled institutions of higher education, private institutions of higher education, independent school districts, small businesses, other for-profit organizations (beyond small businesses), and nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education in those nonprofit categories). The announcement also explicitly includes Native American tribal governments and tribal organizations, public housing authorities/Indian housing authorities, and a category for "others" with further clarification in the full text. In addition, it highlights eligibility for several mission-driven and capacity-building institution types and community-centered organizations, including Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and regional organizations. Importantly, non-U.S. entities are eligible: foreign organizations and foreign institutions can apply, non-U.S. components of U.S. organizations may participate, and foreign components are allowed as defined by the NIH Grants Policy Statement. This international eligibility reflects the reality that aging biology and model development efforts are global and benefit from shared resources and specialized expertise.

There is no cost-sharing or matching requirement, which reduces barriers to entry and makes the program more accessible to organizations that may not have large pools of discretionary funds to contribute. The opportunity was posted and created on March 22, 2013, with an original closing date of September 7, 2016, and a current closing date also listed as September 7, 2016. It was archived on October 8, 2016, meaning it is no longer an active application opportunity in its listed form, although similar NIH program announcements may exist under updated numbers or reissued announcements. The full details were provided through an NIH grants webpage (the "PA" link listed in the source), which is where applicants would normally find specific requirements, review criteria, and any special considerations about the types of animal models, characterization standards, or allowable costs.

For practical support, the contact information points applicants to the NIH Office of Extramural Research (OER) webmaster email addresses for help accessing the announcement or resolving linking issues. In other words, the listed contacts are primarily for technical assistance with the announcement materials rather than scientific programmatic questions. Overall, the opportunity can be understood as NIH's push to strengthen the foundation of aging research by investing in the tools the field relies on: better, more informative, and better-validated animal models that can more reliably translate aging biology insights into broader scientific and health advances.

Frequently Asked Questions (FAQs)

What is the title of this NIH funding opportunity?

The opportunity is titled Development and Characterization of Animal Models for Aging Research (R21).

What type of grant mechanism does this announcement use?

This announcement uses the NIH R21 mechanism, which is typically intended for early-stage, exploratory projects that emphasize innovation and feasibility.

What is the opportunity number or identifier?

The NIH program announcement identifier provided is PA 13-156.

What is the main goal of this funding opportunity?

The central goal is to push aging research forward by supporting projects that develop new animal models or improve and more thoroughly characterize existing animal models so they become more informative for studying the biology of aging and age-related processes.

What kinds of projects is NIH looking to fund under this announcement?

NIH is looking for projects that create, validate, refine, and enhance animal models to make them more useful, reproducible, and relevant for research on aging mechanisms and age-associated conditions.

Is the focus on testing a scientific hypothesis, or on building the model itself?

The overarching theme is that the animal models themselves are the target of development and improvement, rather than using a standard model only as a tool to pursue an unrelated hypothesis.

What does it mean that this is an R21 opportunity?

In this context, the R21 mechanism is described as a good fit for promising ideas that still need foundational work, such as establishing a new model system, collecting key characterization data, or demonstrating proof-of-concept for how a refined model can answer aging-related scientific questions.

What are examples of improvement or characterization areas mentioned?

Depending on the project, this can include improving how aging phenotypes are measured, strengthening links between animal phenotypes and human aging biology, or increasing the model's utility through better genetic, behavioral, physiological, or pathological characterization.

What funding category is this opportunity listed under?

It is categorized as a discretionary grant in the health funding area.

Which CFDA numbers are associated with this opportunity?

The opportunity is connected to NIH program areas reflected by CFDA numbers 93.866 (Aging Research) and 93.173 (Research Related to Deafness and Communication Disorders).

Why is Deafness and Communication Disorders (CFDA 93.173) mentioned in an aging models opportunity?

Based on the provided description, the inclusion suggests that improved aging models can be relevant to specific age-associated functional domains, including communication and sensory systems, where age-related decline is common and where better models can clarify biological mechanisms and potential interventions.

Who is eligible to apply?

Eligibility is described as broad and includes many U.S. public and private entities as well as international organizations.

Are U.S. state and local government entities eligible?

Yes. Eligible applicants include state and local governments such as county governments, city or township governments, and special district governments.

Are colleges and universities eligible?

Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.

Are independent school districts eligible?

Yes. Independent school districts are listed as eligible applicants.

Are small businesses eligible?

Yes. Small businesses are included in the eligible applicant types.

Are other for-profit organizations eligible (beyond small businesses)?

Yes. The eligibility list includes other for-profit organizations beyond small businesses.

Are nonprofit organizations eligible?

Yes. Nonprofit organizations with or without 501(c)(3) status are included, as long as they are not institutions of higher education in those nonprofit categories.

Are Native American tribal governments and tribal organizations eligible?

Yes. The announcement explicitly includes Native American tribal governments and tribal organizations.

Are public housing authorities or Indian housing authorities eligible?

Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.

Are mission-driven or capacity-building institution types specifically highlighted as eligible?

Yes. The description highlights eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).

Are faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations are explicitly mentioned as eligible.

Are regional organizations eligible?

Yes. Regional organizations are explicitly mentioned as eligible.

Are foreign organizations eligible to apply?

Yes. Non-U.S. entities are eligible: foreign organizations and foreign institutions can apply.

Can non-U.S. components of U.S. organizations participate?

Yes. Non-U.S. components of U.S. organizations may participate.

Are foreign components allowed under this announcement?

Yes. Foreign components are allowed as defined by the NIH Grants Policy Statement.

Is there a cost-sharing or matching requirement?

No. The opportunity states there is no cost-sharing or matching requirement.

When was this opportunity posted?

The opportunity was posted and created on March 22, 2013.

What is the closing date for this opportunity?

The original closing date is listed as September 7, 2016, and the current closing date is also listed as September 7, 2016.

Is this funding opportunity still active?

No. It was archived on October 8, 2016, meaning it is no longer an active application opportunity in its listed form.

If it is archived, could similar NIH opportunities still exist?

Yes. The description notes that although this specific announcement is no longer active, similar NIH program announcements may exist under updated numbers or reissued announcements.

Where would applicants normally find full details and requirements?

Full details were provided through an NIH grants webpage (the "PA" link referenced in the source). That NIH page is where applicants would normally find specific requirements, review criteria, and any special considerations (for example, around animal model types, characterization standards, or allowable costs).

Who is listed as the contact for support?

The contact information points applicants to the NIH Office of Extramural Research (OER) webmaster email addresses.

What kind of help do the listed contacts provide?

Based on the description, the listed contacts are primarily for technical assistance with accessing the announcement or resolving linking issues, rather than for scientific or programmatic questions.

In plain terms, what is NIH trying to achieve through this program?

NIH is aiming to strengthen the foundation of aging research by investing in the tools the field relies on: better, more informative, better-validated animal models that can more reliably support research on aging biology and age-related processes.

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