Opportunity Information: Apply for PA 16 181
Apply for PA 16 181
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R41/R42)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351,.
- This funding opportunity was created on Apr 11, 2016 and posted on Apr 11, 2016.
- Applicants must submit their applications by Apr 05, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The grant opportunity titled "Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R41/R42)" is a National Institutes of Health (NIH) funding announcement run through the Department of Health and Human Services, with the program housed in the Office of Research Infrastructure Programs (ORIP). Its core purpose is to push forward the practical, usable infrastructure behind biomedical research by supporting new or improved animal models of human disease, along with the biological materials and enabling technologies needed to create, validate, maintain, and share those models. The emphasis is not just on basic discovery, but on approaches that make animal models more reliable, more informative for human health research, and more feasible to use across the research community.
A central theme of the opportunity is the development and improvement of high-quality animal models and related resources. ORIP describes its mission around creating, developing, preserving, and supplying animal models and associated biological materials, which can include things like specialized strains, genetically engineered lines, tissues, and other model-derived resources that researchers depend on to study disease mechanisms and test interventions. Projects responsive to this announcement would typically address real bottlenecks in the animal-model pipeline: improving how models are generated, strengthening how they are characterized (for example, making sure the model truly reflects the human condition it is meant to mimic), increasing reproducibility and quality, and enabling broader access or more consistent supply.
The opportunity also explicitly supports tools, devices, and technologies that directly improve the welfare of research animals and the operations of animal research programs. That includes innovations that improve handling, reduce stress or pain, refine procedures, improve housing or monitoring, and ease the management of animal facilities. In practice, this can cover a wide range of engineering and biotech solutions such as better monitoring and imaging systems, refined husbandry or environmental control tools, improved identification or tracking systems, and devices that help implement best practices in animal care while also improving the quality of the data generated from animal studies.
This funding announcement is specifically aimed at small business applicants and uses the Small Business Technology Transfer (STTR) mechanism, which is designed for projects where a small business collaborates with a research institution to move an innovation from development toward commercialization. The activity code referenced in the title, R41/R42, signals a phased approach typical for STTR. Phase I (R41) generally supports early-stage proof-of-concept and feasibility work, while Phase II (R42) supports further development, refinement, and steps toward a product or service that can be adopted by the research community. The commercialization aspect is important here: the end goal is not only to demonstrate a scientific advance, but to create a deliverable technology or resource that can be used in real-world research settings and sustained beyond the grant period.
From an administrative standpoint, the opportunity is categorized as a discretionary grant in the health funding activity area, with CFDA numbers listed as 93.351 (and also associated with 93.351 in NIH infrastructure-related programs). The funding opportunity number is PA 16 181, and it was originally created and posted on April 11, 2016. The closing date provided in the source information is April 5, 2019. The sponsoring agency is shown as HHS-NIH, reflecting NIH oversight and the ORIP programmatic home. The eligible applicant category is explicitly small businesses, aligning with the STTR program requirements.
Overall, this FOA is best understood as an NIH effort to strengthen the foundation of biomedical research by investing in commercially viable technologies and resources that make animal models more accurate, more humane, and more practical to use. Successful proposals would be expected to offer innovative, clearly differentiated approaches that address emerging biomedical challenges, improve translation to human health outcomes, and simultaneously support the responsible care and welfare of the animals involved in research.
Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The opportunity is titled "Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R41/R42)."
Which federal agency is sponsoring this opportunity?
The sponsoring agency is the Department of Health and Human Services (HHS), through the National Institutes of Health (NIH).
Which NIH program is associated with this funding announcement?
The program is housed in the Office of Research Infrastructure Programs (ORIP).
What is the core purpose of this funding announcement?
The purpose is to advance practical, usable biomedical research infrastructure by supporting new or improved animal models of human disease, plus the biological materials and enabling technologies needed to create, validate, maintain, and share those models.
Does this opportunity focus on basic research or practical deliverables?
It emphasizes practical, usable infrastructure and deliverable outputs. The intent is not only discovery, but approaches that make animal models more reliable, more informative for human health research, and more feasible to use across the research community.
What kinds of projects are considered responsive to this opportunity?
Projects that address bottlenecks in the animal-model pipeline are responsive, including improved methods to generate models, stronger characterization to ensure models reflect the intended human condition, improved reproducibility and quality, and approaches that broaden access or ensure consistent supply of models and related resources.
What does "create, characterize, or improve animal models" mean in practice?
Based on the description provided, it can include developing new models, refining existing models to better match human disease biology, and building robust characterization workflows to validate that the model reflects the human condition it is intended to mimic.
What types of animal-model-related resources can be supported?
The announcement includes animal models and associated biological materials such as specialized strains, genetically engineered lines, tissues, and other model-derived resources that researchers rely on to study disease mechanisms and test interventions.
Is improving reproducibility and quality of animal models part of the focus?
Yes. The opportunity highlights increasing reproducibility and quality, as well as improving how models are generated and characterized.
Does the opportunity include sharing or supplying models to the broader research community?
Yes. The goal includes enabling broader access and more consistent supply, and supporting infrastructure that helps maintain and share animal models and related resources.
Are technologies that improve research animal welfare eligible under this announcement?
Yes. The opportunity explicitly supports tools, devices, and technologies that directly improve the welfare of research animals and the operations of animal research programs.
What are examples of animal welfare or facility-operation improvements mentioned?
Examples described include innovations that improve handling, reduce stress or pain, refine procedures, improve housing or monitoring, ease the management of animal facilities, and support best practices in animal care while also improving data quality.
What types of technologies are referenced as potentially relevant?
The text mentions a range of engineering and biotech solutions such as better monitoring and imaging systems, refined husbandry or environmental control tools, improved identification or tracking systems, and devices that improve animal care and data quality.
Who is eligible to apply for this grant opportunity?
The eligible applicant category is explicitly small businesses.
What funding mechanism is used for this opportunity?
This announcement uses the Small Business Technology Transfer (STTR) mechanism, designed for projects where a small business collaborates with a research institution to move an innovation toward commercialization.
What do the activity codes R41 and R42 mean for applicants?
They indicate a phased STTR approach. Phase I (R41) generally supports early-stage proof-of-concept and feasibility work, while Phase II (R42) supports further development, refinement, and steps toward a product or service that can be adopted by the research community.
How important is commercialization in this FOA?
Commercialization is a central element. The end goal is not only a scientific advance, but a deliverable technology or resource that can be used in real-world research settings and sustained beyond the grant period.
What kinds of outcomes does NIH/ORIP appear to be seeking?
The description suggests ORIP is seeking innovative, clearly differentiated approaches that address emerging biomedical challenges, improve translation to human health outcomes, strengthen infrastructure, and support responsible animal care and welfare.
How is this opportunity categorized from an administrative standpoint?
It is categorized as a discretionary grant in the health funding activity area.
What is the funding opportunity number (FOA number)?
The funding opportunity number provided is PA 16 181.
When was this funding opportunity originally created and posted?
It was originally created and posted on April 11, 2016.
What closing date is listed in the provided information?
The closing date shown is April 5, 2019.
What CFDA number is associated with this opportunity?
The CFDA number listed is 93.351 (and it is also described as associated with 93.351 in NIH infrastructure-related programs).
Which agency is shown as the sponsoring agency in the source information?
The sponsoring agency is shown as HHS-NIH, reflecting NIH oversight and ORIP as the programmatic home.
Browse more opportunities from the same category: Health
Next opportunity: New Mexico Conservation Innovation Grants
Previous opportunity: Smart Reentry: Focus on Evidence-Based Strategies for Successful Reentry from Incarceration to Community
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 16 181
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 16 181) also looked into and applied for these:
| Funding Opportunity |
|---|
| Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R43/R44) Apply for PA 16 180 Funding Number: PA 16 180 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Short-term Mentored Career Enhancement Award in Dental, Oral and Craniofacial Research for Mid-Career and Senior Investigators (K18) Apply for PAR 16 179 Funding Number: PAR 16 179 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Strategies for the Improvement of HIV Envelope Protein Expression and Yield (R41/R42) Apply for PA 16 182 Funding Number: PA 16 182 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Products to Support Applied Research Towards Zero Suicide Healthcare Systems (R43/R44) Apply for PAR 16 185 Funding Number: PAR 16 185 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| Strategies for the Improvement of HIV Envelope Protein Expression and Yield (R43/R44) Apply for PA 16 184 Funding Number: PA 16 184 Agency: HHS-NIH11 Category: Health Funding Amount: Case Dependent |
| The USAID Global Health Challenge BAA Apply for BAA GLOBAL HEALTH 2016 Funding Number: BAA GLOBAL HEALTH 2016 Agency: USAID Category: Health Funding Amount: Case Dependent |
| Implementing Public Health Programs and Strengthening Public Health Capacity in Guatemala and Central American Apply for CDC RFA GH13 130604CONT16 Funding Number: CDC RFA GH13 130604CONT16 Agency: HHS-CDC Category: Health Funding Amount: Case Dependent |
| Natural History Studies for Rare Disease Product Development: Orphan Products Research Project Grant (R01) Apply for RFA FD 16 043 Funding Number: RFA FD 16 043 Agency: HHS-FDA Category: Health Funding Amount: $400,000 |
| Health Informatics Governance and Data Analytics (HIGDA) Apply for RFA 615 16 000009 Funding Number: RFA 615 16 000009 Agency: USAID-KEN Category: Health Funding Amount: $17,000,000 |
| Enhanced Access to and Utilization of Quality Family Planning/Reproductive, Maternal, Newborn, Child and Adolescent Health (FP/RMNCAH) Services in Selected Counties and Sub-counties, Kenya – (AFYA FP/RMNCAH). Apply for RFA 615 16 000007 Funding Number: RFA 615 16 000007 Agency: USAID-KEN Category: Health Funding Amount: $64,500,000 |
| NHLBI TOPMed Program: Integrative Omics Approaches for Analysis of TOPMed Data (U01) Apply for RFA HL 17 011 Funding Number: RFA HL 17 011 Agency: HHS-NIH11 Category: Health Funding Amount: $400,000 |
| New Access Points Apply for HRSA 17 009 Funding Number: HRSA 17 009 Agency: HHS-HRSA Category: Health Funding Amount: Case Dependent |
| HIV Pre-exposure Prophylaxis (PrEP) Implementation Science in CDC-funded Public Health Demonstration Projects (Admin Supp) Apply for PA 16 199 Funding Number: PA 16 199 Agency: HHS-NIH11 Category: Health Funding Amount: $175,000 |
| HUMAN RESOURCES FOR HEALTH (HRH) KENYA PROGRAM Apply for RFA 615 16 000008 Funding Number: RFA 615 16 000008 Agency: USAID-KEN Category: Health Funding Amount: $38,000,000 |
| County Measurements, Learning and Accountability Program (CMLAP) Apply for RFA 615 16 000010 Funding Number: RFA 615 16 000010 Agency: USAID-KEN Category: Health Funding Amount: $17,750,000 |
| Small Market Awards: SBIR Phase IIB Competing Renewals for Heart, Lung, Blood, and Sleep Technologies with Small Commercial Markets (R44) Apply for RFA HL 17 012 Funding Number: RFA HL 17 012 Agency: HHS-NIH11 Category: Health Funding Amount: $3,000,000 |
| Assisted Outpatient Treatment Grant Program for Individuals with Serious Mental Illness, (Short Title: Assisted Outpatient Treatment [AOT]) Apply for SM 16 011 Funding Number: SM 16 011 Agency: HHS-SAMHS Category: Health Funding Amount: $1,000,000 |
| Grants to Support the Hispanic Health Services Research Grant Program Apply for CMS 1H0 16 001 Funding Number: CMS 1H0 16 001 Agency: HHS-CMS Category: Health Funding Amount: $215,000 |
| Epidemiology Program for American Indian/Alaska Native Tribes and Urban Indian Communities Apply for HHS 2016 IHS EPI 0001 Funding Number: HHS 2016 IHS EPI 0001 Agency: HHS-IHS Category: Health Funding Amount: $1,000,000 |
| Grants to Support the Historically Black Colleges and Universities Health Services Research Grant Program Apply for CMS 1I0 16 001 Funding Number: CMS 1I0 16 001 Agency: HHS-CMS Category: Health Funding Amount: $215,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 16 181", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.