Opportunity Information: Apply for EPA G2012 STAR F1
Apply for EPA G2012 STAR F1
- The Environmental Protection Agency in the environment sector is offering a public funding opportunity titled "Development and Use of Adverse Outcome Pathways that Predict Adverse Developmental Neurotoxicity" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 66.509 Science To Achieve Results (STAR) Research Program.
- This funding opportunity was created on Dec 5, 2012 and posted on Sep 14, 2012.
- Applicants must submit their applications by Dec 19, 2012 Please refer to the full announcement, including Section IV, for additional information on submission methods and due dates.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- See Section III of the announcement for additional eligibility information.
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Opportunity Summary:
The Environmental Protection Agency (EPA) is offering funding through its Science to Achieve Results (STAR) Research Program for research focused on adverse outcome pathways (AOPs) that lead to developmental neurotoxicity (DNT). The central goal of this opportunity is to support projects that can identify new AOPs or substantially improve understanding of existing ones by clearly connecting the chain of biological events from a chemical exposure to measurable harmful neurodevelopmental outcomes. EPA is looking for research that does more than describe isolated effects; it should map and link key events along the full continuum from initial molecular interactions through cellular and tissue changes and, ultimately, to adverse outcomes relevant to developing nervous systems. A strong emphasis is placed on characterizing windows of susceptibility, meaning proposals should consider how timing of exposure during development influences risk and outcome.
A major expected product of the funded work is practical AOP-based data and predictive models that can be used in chemical testing and regulatory risk assessment. In other words, EPA wants research that helps risk assessors forecast developmental neurotoxicity more reliably, potentially improving how chemicals are screened and prioritized and reducing uncertainty in decisions that protect children and other sensitive populations. While the program is especially interested in AOPs involving endocrine signaling pathways that disrupt neurodevelopment (reflecting concern about endocrine-active chemicals and hormone-dependent brain development), it is not limited to endocrine mechanisms. Proposals addressing other relevant AOPs tied to DNT are also eligible, as long as they advance the ability to connect mechanistic steps to adverse neurodevelopmental outcomes in a way that supports prediction and testing.
Administratively, this is a discretionary funding opportunity (Funding Opportunity Number EPA G2012 STAR F1) using grant and cooperative agreement instruments under CFDA 66.509 (STAR Research Program). EPA anticipated making about five awards with an estimated total program funding level of $4,000,000. Individual awards could be as large as $800,000, with no stated minimum award amount (award floor listed as $0). There is no cost-sharing or matching requirement indicated. The opportunity was posted September 14, 2012, with an original closing date of December 12, 2012, later updated to a current closing date of December 19, 2012; applicants were instructed to consult the full announcement (especially Section IV) for the official submission method and due-date details. The opportunity was archived January 18, 2013. Eligibility is described broadly as "Others" with additional specifics provided in Section III of the full announcement.
For applicants needing help, EPA provided separate points of contact depending on the issue. Questions about eligibility could be directed to Bronda Harrison at harrison.bronda@epa.gov or 703-347-8080. Questions related to electronic submission were routed to Todd Peterson at peterson.todd@epa.gov or 703-308-7224. Technical questions about the scientific scope could be directed to Mitch Lasat at lasat.mitch@epa.gov or 703-347-8099.
Frequently Asked Questions (FAQs)
1. What is the main purpose of this EPA funding opportunity?
The opportunity supports research under the EPA Science to Achieve Results (STAR) Research Program focused on adverse outcome pathways (AOPs) that lead to developmental neurotoxicity (DNT). The core aim is to identify new AOPs or substantially improve existing AOPs by clearly connecting the chain of biological events from chemical exposure to measurable harmful neurodevelopmental outcomes.
2. What type of research is EPA looking for?
EPA is looking for research that goes beyond describing isolated effects. Proposed projects should map and link key events across the full continuum from initial molecular interactions, through cellular and tissue changes, and ultimately to adverse outcomes relevant to developing nervous systems.
3. What does it mean to "connect the chain of biological events" in an AOP?
In this context, it means showing how a chemical exposure initiates a biological interaction at the molecular level and how that interaction progresses through intermediate key events (such as changes in cells or tissues) to produce an adverse neurodevelopmental outcome that can be measured and is relevant to developmental neurotoxicity.
4. Is developmental timing important for proposed projects?
Yes. A strong emphasis is placed on characterizing windows of susceptibility. Proposals should consider how the timing of exposure during development influences risk and the resulting neurodevelopmental outcomes.
5. What are "windows of susceptibility" in this opportunity?
Windows of susceptibility refer to developmental periods when exposure timing may change the likelihood, severity, or type of neurodevelopmental harm. The announcement indicates EPA expects applicants to consider how risk and outcomes differ depending on when exposure occurs during development.
6. What are the expected deliverables or outcomes from funded work?
A major expected product is practical AOP-based data and predictive models that can be used in chemical testing and regulatory risk assessment. EPA is seeking results that help forecast developmental neurotoxicity more reliably and reduce uncertainty in decisions intended to protect children and other sensitive populations.
7. How will EPA use the results of the research?
The funding is intended to produce AOP-based information and predictive models that can support chemical testing and regulatory risk assessment, including improving how chemicals are screened and prioritized and reducing uncertainty in risk assessment decisions.
8. Are endocrine-related AOPs required?
No. The program is especially interested in AOPs involving endocrine signaling pathways that disrupt neurodevelopment, but proposals are not limited to endocrine mechanisms. Other AOPs tied to developmental neurotoxicity are also eligible if they advance the ability to connect mechanistic steps to adverse outcomes in ways that support prediction and testing.
9. What kinds of proposals are less aligned with EPA's stated interests?
Based on the description provided, proposals that only describe isolated effects without linking key events across the pathway from molecular initiation to adverse neurodevelopmental outcomes would be less aligned with the stated emphasis on mapping and connecting the full AOP continuum.
10. What is the program name and identifier for this opportunity?
The opportunity is offered through EPA's Science to Achieve Results (STAR) Research Program. The Funding Opportunity Number is EPA G2012 STAR F1, and it uses CFDA 66.509 (STAR Research Program).
11. What type of funding instrument will be used?
The opportunity is described as discretionary funding using grant and cooperative agreement instruments.
12. How much total funding did EPA anticipate for this competition?
EPA anticipated an estimated total program funding level of $4,000,000.
13. How many awards did EPA expect to make?
EPA anticipated making about five awards.
14. What is the maximum award size?
Individual awards could be as large as $800,000.
15. Is there a minimum award amount?
No minimum award amount is stated. The award floor is listed as $0.
16. Is cost sharing or matching required?
No. The information provided indicates there is no cost-sharing or matching requirement.
17. When was the opportunity posted?
The opportunity was posted on September 14, 2012.
18. What was the deadline to apply?
The original closing date was December 12, 2012, and it was later updated to a current closing date of December 19, 2012. Applicants were instructed to consult the full announcement (especially Section IV) for the official submission method and due-date details.
19. Is this opportunity still open?
No. The opportunity was archived on January 18, 2013.
20. Where can applicants find the official submission instructions?
Applicants were instructed to consult the full announcement, especially Section IV, for the official submission method and due-date details.
21. Who is eligible to apply?
Eligibility is described broadly as "Others," with additional specifics provided in Section III of the full announcement.
22. Who should be contacted with eligibility questions?
Eligibility questions could be directed to Bronda Harrison at harrison.bronda@epa.gov or 703-347-8080.
23. Who should be contacted for electronic submission questions?
Questions related to electronic submission were routed to Todd Peterson at peterson.todd@epa.gov or 703-308-7224.
24. Who should be contacted for technical questions about the scientific scope?
Technical questions about the scientific scope could be directed to Mitch Lasat at lasat.mitch@epa.gov or 703-347-8099.
25. What should a strong proposal emphasize, based on the description provided?
A strong proposal should (1) identify or significantly improve an AOP for developmental neurotoxicity, (2) link key events from molecular initiation to measurable adverse neurodevelopmental outcomes, (3) address windows of susceptibility related to timing of exposure during development, and (4) produce practical AOP-based data and predictive models useful for chemical testing and regulatory risk assessment.
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