Development of Animal Models and Related Biological Materials For Research (R21) | Apply Online

Opportunity Summary:

The National Institutes of Health (NIH), through the National Center for Research Resources (NCRR), offered this grant opportunity to support early-stage, exploratory projects aimed at creating, improving, or better characterizing animal models and related biological materials that are useful for biomedical research. The central idea is to strengthen research infrastructure by enabling investigators to develop animal models of human disease or to improve the detection, diagnosis, prevention, and control of diseases in laboratory animals that could otherwise compromise research results. A key requirement is that the proposed model or resource needs to be broadly valuable, meaning it should be relevant to the research priorities of at least two different NIH Institutes or Centers rather than serving only a narrow, single-disease purpose.

This opportunity uses the NIH R21 mechanism, which is designed for exploratory or developmental work where the goal is to generate proof-of-concept data, establish feasibility, or open up new directions rather than complete a fully mature, large-scale research program. Projects might include building a new disease model, refining an existing one to improve how closely it mirrors human biology, or developing associated biological materials that make the model easier to use and distribute. On the laboratory-animal health side, applications could focus on methods to identify or manage infections and conditions that interfere with experiments, which is important because underlying animal health issues can distort data, reduce reproducibility, and increase costs across many fields.

NCRR strongly encouraged applicants to contact program staff early to confirm that their concept fit the scope of this announcement. That guidance matters because proposals that mainly serve a single disease area and do not have broad cross-cutting utility were expected to be routed instead to the most relevant NIH “categorical” institute. For example, a model focused primarily on cancer biology or cardiovascular disease would likely be a better match for the National Cancer Institute or the National Heart, Lung, and Blood Institute, respectively, which often have their own targeted funding opportunities for disease-specific model development.

Funding levels and the number of awards were not fixed because NCRR anticipated wide variation in project scope, duration, and cost. The listing includes an award ceiling of $200,000, and overall funding decisions were expected to depend on the number of applications received, their scientific quality, and their requested budgets and timelines. There was no cost sharing or matching requirement, which means applicants were not required to contribute non-federal funds as a condition of receiving an award.

Eligibility was broad and included many types of organizations: public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), state governments, for-profit organizations (other than small businesses), Native American tribal governments and tribal organizations, and a range of special classifications such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. This broad eligibility aligns with the infrastructure-oriented nature of the program, since useful animal models and colony health tools can be developed in many institutional settings.

Administratively, this was a discretionary grant opportunity issued under NIH, tied to CFDA programs 93.351 (Research Infrastructure Programs) and 93.389 (National Center for Research Resources). The opportunity was posted March 16, 2010, with later record dates shown in the listing, and it ultimately closed in March 2013 and was archived in April 2013. The full announcement was available through the NIH Grants Guide (PA-10-138), and applicants needing technical help accessing the announcement were directed to NIH’s Office of Extramural Research (OER) webmaster contact.

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