Opportunity Information: Apply for PA 07 320
Apply for PA 07 320
- The National Institutes of Health in the education food and nutrition health sector is offering a public funding opportunity titled "Development of Assays for High Throughput Drug Screening (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.395 Cancer Treatment Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Mar 19, 2007.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Private institutions of higher education Public and State controlled institutions of higher education Independent school districts County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Special district governments City or township governments Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) State governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply.
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Opportunity Summary:
The Development of Assays for High Throughput Drug Screening (R01) opportunity (Funding Opportunity Number PA 07-320) is a National Institutes of Health (NIH) grant that focuses on creating and refining research assays that can eventually be used in high throughput screening (HTS). This program sits within the broader Molecular Libraries Initiative, which was part of the NIH Roadmap for Medical Research. The central idea is to make sophisticated, industry-style screening approaches available to public sector researchers, so that universities, nonprofits, and other research organizations can systematically test large numbers of small molecules and identify candidates that could become useful research tools or even the early starting points for new therapies.
The purpose of the funding announcement is specifically about assay development rather than running full-scale screening campaigns. Applicants are expected to propose innovative assays that have a credible pathway to being adapted for automation and HTS environments. In practical terms, that means designing assays with clear, measurable readouts, reproducibility, and performance characteristics that can survive the demands of screening many compounds quickly. The assays should be aimed at discovering either (1) new tools that help scientists study biology and disease mechanisms more effectively, or (2) promising new directions for therapeutic development. NIH also emphasizes alignment with the scientific missions of the participating NIH institutes, which include areas reflected in the listed CFDA programs such as mental health, cancer treatment, diabetes and kidney-related research, and microbiology/infectious diseases.
The mechanism of support is the NIH R01 Research Project Grant, which is typically used for substantial, hypothesis-driven or technology-enabling research projects. Under this announcement, applicants may request up to a three-year project period. The announcement also draws a line between projects that are still in the assay creation and optimization stage versus those that are already essentially ready to be run on automated platforms. If an investigator already has an assay that is sufficiently mature for automated screening, NIH points them toward a different opportunity (PAR 06-545), which uses the R03 mechanism and is generally more appropriate for smaller, more targeted efforts closer to immediate screening readiness.
Funding levels and the number of awards are not fixed in advance. NIH indicates that awards depend on the availability of funds and, importantly, on the volume and quality of applications received. In other words, this is a competitive scientific merit-based program where the final portfolio and total dollars awarded can vary from cycle to cycle. The posting date for the opportunity is March 19, 2007, with multiple receipt dates (meaning there were several submission windows rather than one single deadline), and the opportunity was later archived on June 1, 2010.
Eligibility is broad and includes many types of domestic organizations such as public and private institutions of higher education, state and local governments, school districts, special district governments, certain housing authorities, and nonprofits both with and without 501(c)(3) status (with some distinctions). Notably, foreign institutions are eligible to apply, and eligible federal agencies may also apply, which is not true for every NIH program announcement. The listing identifies the opportunity category as discretionary and the instrument as a grant, and it specifies that there is no cost-sharing or matching requirement, meaning applicants are not required to contribute a defined portion of the project cost from non-federal sources.
Overall, this FOA is best understood as an NIH effort to strengthen the early pipeline that makes HTS possible: robust, scalable, and biologically meaningful assays. By funding assay innovation and preparation for automation, NIH is trying to increase the number and quality of screening-ready systems available to the research community, with the longer-term aim of accelerating the discovery of chemical probes and potential therapeutic leads in mission-relevant disease areas.
FAQs: Development of Assays for High Throughput Drug Screening (R01) - PA 07-320
What is the goal of the PA 07-320 funding opportunity?
The opportunity supports the creation and refinement of research assays that can eventually be used in high throughput screening (HTS). The emphasis is on developing assays with a realistic path to automation and large-scale compound testing, rather than running full screening campaigns.
Which agency offers this grant opportunity?
This is a National Institutes of Health (NIH) funding opportunity.
What is the Funding Opportunity Number (FON) for this program?
The Funding Opportunity Number is PA 07-320.
What grant mechanism is used?
The mechanism of support is the NIH R01 Research Project Grant.
How long can the project period be under this announcement?
Applicants may request up to a three-year project period.
Is this opportunity focused on screening compounds or developing assays?
It is focused on assay development and optimization. The program is intended to fund innovative assays that can be adapted for automation and HTS, not to fund full-scale screening campaigns.
What kinds of assays are appropriate for this FOA?
Appropriate projects propose innovative assays with credible plans for adaptation to automation and HTS environments. Assays should have clear and measurable readouts, demonstrate reproducibility, and include performance characteristics that can hold up when many compounds are tested quickly.
What is meant by "a credible pathway to automation and HTS"?
It means the assay is designed or refined so it can be transitioned into an automated, high-throughput setting. Practical considerations include a robust signal/readout, repeatability, and performance suitable for rapid testing across large numbers of small molecules.
What outcomes is NIH looking for from funded assay development work?
NIH highlights assays aimed at discovering either (1) new tools that help scientists study biology and disease mechanisms more effectively, or (2) promising early starting points or directions for therapeutic development.
How does this FOA relate to the Molecular Libraries Initiative?
This program sits within the broader Molecular Libraries Initiative, part of the NIH Roadmap for Medical Research. The broader aim is to make sophisticated, industry-style screening approaches available to public sector researchers.
Who is the intended research community for the assays supported by this program?
The intent is to broaden access to HTS-style capabilities for public sector researchers, including universities, nonprofits, and other research organizations, enabling systematic testing of large numbers of small molecules.
How should applicants think about alignment with NIH missions?
NIH emphasizes that projects should align with the scientific missions of participating NIH institutes. The opportunity references mission-relevant areas reflected in listed CFDA programs, including mental health, cancer treatment, diabetes and kidney-related research, and microbiology/infectious diseases.
What if an investigator already has an assay that is ready for automated screening?
If the assay is already sufficiently mature for automated screening, NIH points applicants to a different opportunity: PAR 06-545, which uses the R03 mechanism and is described as more appropriate for smaller, targeted efforts closer to screening readiness.
What is the difference between this R01 opportunity and PAR 06-545?
Based on the information provided, PA 07-320 (R01) is aimed at assay development and refinement toward HTS, while PAR 06-545 (R03) is positioned for projects where the assay is already mature and closer to immediate automated screening use.
Are funding levels or the number of awards predetermined?
No. NIH does not fix funding levels or the number of awards in advance. Awards depend on the availability of funds and the volume and quality of applications received.
Is this considered a competitive program?
Yes. The description indicates a competitive, scientific merit-based program where the portfolio and total funding can vary from cycle to cycle based on application quality and available funds.
When was this opportunity posted, and what is its current status?
The posting date is March 19, 2007. The opportunity had multiple receipt dates (several submission windows) and was later archived on June 1, 2010.
Did the FOA have a single deadline?
No. The opportunity had multiple receipt dates, meaning there were several submission windows rather than one single deadline.
What types of organizations are eligible to apply?
Eligibility is broad. It includes public and private institutions of higher education, state and local governments, school districts, special district governments, certain housing authorities, and nonprofit organizations (both with and without 501(c)(3) status, with some distinctions).
Are foreign institutions eligible to apply?
Yes. Foreign institutions are eligible under this opportunity.
Can federal agencies apply?
Yes. Eligible federal agencies may apply, which is not the case for every NIH program announcement.
What is the opportunity category and funding instrument?
The opportunity category is listed as discretionary, and the instrument is a grant.
Is there a cost-sharing or matching requirement?
No. The opportunity specifies there is no cost-sharing or matching requirement, meaning applicants are not required to contribute a defined portion of project costs from non-federal sources.
What is the larger objective behind NIH funding for assay development for HTS?
The FOA is positioned as an effort to strengthen the early pipeline that makes HTS possible by increasing the number and quality of robust, scalable, biologically meaningful assays that can become screening-ready systems for the research community.
What kinds of discoveries could these assays enable in the long term?
The longer-term aim described is to accelerate the discovery of chemical probes and potential therapeutic leads in disease areas relevant to NIH institute missions.
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