Opportunity Information: Apply for PAR 26 106
Apply for PAR 26 106
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310, 93.352.
- This funding opportunity was created on 2026-03-06.
- Applicants must submit their applications by 2028-01-25.
- Each selected applicant is eligible to receive up to $8,000,000.00 in funding.
- The number of recipients for this funding is limited to 14 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Opportunity Summary:
The Development of Collaborative Research Facilities or Research-Resource Facilities (C06 Clinical Trial Not Allowed) opportunity (PAR-26-106) is a National Institutes of Health (NIH) construction-focused grant program designed to expand or improve shared-use research spaces and research-supporting infrastructure that multiple investigators and programs can rely on. The central idea is to fund facilities that make collaboration easier and more productive, strengthen research capacity, and produce long-lasting benefits for a broad scientific community rather than serving a narrow, single-lab purpose. This funding is intended for physical facility development, such as construction, renovation, modernization, or creation of dedicated shared resource environments that enable biomedical research activities at scale.
The NOFO supports two established NIH construction programs. The first is the Biomedical Research Facilities (BRF) program, which backs construction or modernization of biomedical research facilities that advance basic, translational, clinical, or behavioral science across essentially any biomedical topic area. Examples of the kinds of projects that fit the BRF intent include shared research spaces and cross-cutting cores such as imaging facilities, high-throughput omics cores, advanced microscopy suites, BSL laboratories where justified, vivarium-related modernization when aligned with broad user needs, biorepositories, and other resource facilities designed for shared access. A key theme is that the facility should serve a wide user base and have a significant, sustained impact on an institution or region’s biomedical research ecosystem, not just enable one project or one research group.
The second program is the HIV/AIDS Research Facilities (HRF) program, which funds HIV/AIDS research facilities or facilities that support HIV/AIDS research. Under HRF, proposed facility resources and the research they empower are expected to align with NIH Office of AIDS Research (OAR) priorities. This includes, explicitly, work connected to the long-term health consequences of HIV infection, along with other priority areas identified by OAR. In practice, HRF projects should clearly show how the upgraded or newly developed facility will strengthen HIV/AIDS research capacity, improve the quality or reach of HIV-related studies, and provide shared infrastructure that can be broadly used by HIV/AIDS investigators and their collaborators.
This opportunity is categorized as “Clinical Trial Not Allowed,” which means applicants should not propose a clinical trial as part of the grant’s supported activities. The emphasis is on facilities and the capacity they create rather than conducting clinical intervention studies. While the facilities may ultimately support clinical research environments, the application itself should remain aligned with the construction/modernization and shared resource purpose described in the NOFO and comply with the NIH definition and restrictions around clinical trials for this mechanism.
NIH signals that it is interested in applications from institutions across all U.S. geographic regions and specifically encourages participation from Institutions of Emerging Excellence (IEE) in biomedical research. The broader policy goal is to strengthen the nation’s research capacity by investing in shared infrastructure where it can meaningfully elevate competitiveness, collaboration, and long-term scientific output. Applications should therefore make a strong case for regional or community impact, governance and access plans for shared use, and how the facility will be sustainably operated and maintained for ongoing benefit.
Eligibility is broad and includes many U.S.-based organization types, spanning state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other eligible tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities as described in the NOFO. Despite this wide eligibility, the program is strictly domestic: non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed. In other words, the funded facility development and supported components must remain within allowable U.S. organizational structures without foreign components.
From a funding and logistics standpoint, this is a discretionary NIH grant in the health category (CFDA 93.310 and 93.352). The listed award ceiling is $8,000,000, with an expectation of roughly 14 awards. The original closing date shown is January 25, 2028, indicating a multi-year window during which NIH plans to accept and review applications under this announcement. Applicants should still rely on the NOFO’s detailed instructions for any cycle-specific submission dates, required registrations, and documentation expectations, since NIH construction-related mechanisms typically have detailed facility, architectural, budgeting, and institutional commitment requirements that go beyond standard research grant applications.
Overall, this NOFO is best understood as an infrastructure investment program aimed at building or upgrading shared research environments that catalyze collaborative science. Strong applications will typically demonstrate broad user demand, clear governance and access policies for shared use, alignment with BRF or HRF goals (including OAR priority alignment for HRF), credible project planning and feasibility, and a convincing long-term sustainability plan that ensures the facility remains a durable resource for the broader biomedical research community.
Frequently Asked Questions (FAQs)
What is PAR-26-106 (C06 Clinical Trial Not Allowed) designed to fund?
PAR-26-106 is an NIH construction-focused grant program intended to expand or improve shared-use research spaces and research-supporting infrastructure. The emphasis is on developing physical facilities (construction, renovation, modernization, or creation of dedicated shared resource environments) that enable biomedical research and make collaboration easier and more productive for multiple investigators and programs.
What is the core purpose of this funding opportunity?
The central purpose is to invest in research facilities that strengthen research capacity and produce long-lasting benefits for a broad scientific community. Projects should be designed to support shared access and sustained institutional or regional impact, rather than serving a narrow, single-lab purpose.
What types of activities are considered “facility development” under this opportunity?
Facility development under this opportunity includes physical construction-focused activities such as construction, renovation, modernization, or creation of dedicated shared research-resource spaces and research-supporting infrastructure intended for shared use by multiple investigators and programs.
What are the two NIH construction programs supported by this NOFO?
This NOFO supports two established NIH construction programs: (1) the Biomedical Research Facilities (BRF) program and (2) the HIV/AIDS Research Facilities (HRF) program.
What is the Biomedical Research Facilities (BRF) program?
The BRF program supports construction or modernization of biomedical research facilities that advance basic, translational, clinical, or behavioral science across essentially any biomedical topic area. A key expectation is that the facility will serve a wide user base and provide sustained impact on an institution or region’s biomedical research ecosystem.
What kinds of projects are examples of a good fit for BRF?
Examples described for BRF-aligned projects include shared research spaces and cross-cutting cores such as imaging facilities, high-throughput omics cores, advanced microscopy suites, BSL laboratories where justified, vivarium-related modernization when aligned with broad user needs, biorepositories, and other shared-access resource facilities.
What is the HIV/AIDS Research Facilities (HRF) program?
The HRF program supports HIV/AIDS research facilities or facilities that support HIV/AIDS research. HRF projects are expected to align with NIH Office of AIDS Research (OAR) priorities and show how the facility will strengthen HIV/AIDS research capacity and provide shared infrastructure broadly used by HIV/AIDS investigators and collaborators.
How should HRF applications address NIH Office of AIDS Research (OAR) priorities?
HRF applications are expected to align the proposed facility resources and the research they enable with OAR priorities, including work connected to the long-term health consequences of HIV infection and other priority areas identified by OAR.
What does “Clinical Trial Not Allowed” mean for this opportunity?
“Clinical Trial Not Allowed” means applicants should not propose a clinical trial as part of the grant’s supported activities. The application should remain focused on facilities and the capacity they create, and it must comply with NIH definitions and restrictions around clinical trials for this mechanism.
Can the funded facilities ultimately support clinical research?
Yes. The facilities may ultimately support clinical research environments, but the application itself must stay aligned with the construction/modernization and shared resource purpose of the NOFO and must not propose a clinical trial as part of the supported activities.
What is NIH looking for in terms of collaboration and shared use?
NIH is aiming to fund facilities that enable collaboration and shared access by multiple investigators and programs. Applications are expected to make a strong case for broad user demand and include governance and access plans that support shared use.
Who is encouraged to apply?
NIH is interested in applications from institutions across all U.S. geographic regions and specifically encourages participation from Institutions of Emerging Excellence (IEE) in biomedical research.
What is the policy goal behind encouraging Institutions of Emerging Excellence (IEE)?
The stated policy goal is to strengthen the nation’s research capacity by investing in shared infrastructure where it can meaningfully elevate competitiveness, collaboration, and long-term scientific output.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes many U.S.-based organization types, including: state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other eligible tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities as described in the NOFO.
Are non-U.S. entities eligible to apply?
No. This program is strictly domestic. Non-U.S. entities are not eligible to apply.
Are non-U.S. components of U.S. organizations eligible?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy for this opportunity?
No. Foreign components (as defined by NIH policy) are not allowed for this opportunity.
What is the maximum award amount (award ceiling)?
The listed award ceiling is $8,000,000.
How many awards does NIH expect to make?
The opportunity notes an expectation of roughly 14 awards.
What is the assistance listing / CFDA information for this opportunity?
This is a discretionary NIH grant in the health category, listed under CFDA 93.310 and 93.352.
What is the closing date for this opportunity?
The original closing date shown is January 25, 2028, indicating a multi-year window during which NIH plans to accept and review applications under this announcement.
Does the multi-year closing date mean there are no other deadlines?
Not necessarily. Applicants are advised to rely on the NOFO’s detailed instructions for any cycle-specific submission dates, required registrations, and documentation expectations, since NIH construction-related mechanisms often have detailed requirements beyond standard research grant applications.
What kinds of planning and documentation should applicants be prepared for?
Based on the description, applicants should anticipate detailed facility, architectural, budgeting, and institutional commitment requirements that are typical for NIH construction-focused mechanisms, in addition to standard grant application elements.
What makes an application competitive under this NOFO?
Strong applications will typically demonstrate broad user demand, clear governance and access policies for shared use, alignment with BRF or HRF goals (including OAR priority alignment for HRF), credible project planning and feasibility, and a convincing long-term sustainability plan to operate and maintain the facility for ongoing benefit.
How important is sustainability after construction or modernization?
Sustainability is a key expectation. Applications should describe how the facility will be sustainably operated and maintained so it remains a durable shared resource with long-term value for the broader biomedical research community.
Is this opportunity intended to support a single investigator or single lab?
No. A stated theme is that the facility should provide broad shared access and sustained impact, rather than enabling only one project or one research group.
How should applicants describe impact beyond their institution?
Applicants are expected to make a strong case for regional or community impact, explaining how the facility investment will elevate collaboration, competitiveness, and long-term scientific output for a broad user community.
Does this opportunity support any biomedical topic area?
Under the BRF program, the NOFO indicates support for facilities that advance basic, translational, clinical, or behavioral science across essentially any biomedical topic area. Under HRF, the focus is specifically on HIV/AIDS research capacity aligned with OAR priorities.
Where should an applicant look for definitive rules and submission requirements?
Applicants should rely on the NOFO itself for detailed and authoritative instructions, including submission cycles, registrations, required documents, and any additional construction-related requirements specific to this mechanism.
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