Opportunity Information: Apply for PA 13 140
Apply for PA 13 140
- The National Institutes of Health in the education environment health income security and social services sector is offering a public funding opportunity titled "Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.350 National Center for Advancing Translational Sciences 93.361 Nursing Research 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control 93.837 Cardiovascular Diseases Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research 93.859 Biomedical Research and Research Training 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research.
- This funding opportunity was created on Mar 13, 2013 and posted on Mar 13, 2013.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The NIH SBIR Funding Opportunity Announcement PA 13-140, titled "Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44)," supports small businesses that want to build and validate next-generation technologies for single-cell analysis. The central aim is to push beyond average measurements taken from mixed cell populations and instead develop tools that can reliably distinguish different cellular states within heterogeneous tissues. In practical terms, the NIH is looking for innovations that help researchers separate and characterize subtle cell-to-cell differences that matter for understanding development, normal physiology, and the origins and progression of disease.
This FOA is specifically framed around tool and technology development with a clear path toward commercialization. Applicants are expected to treat the current state of the art as a baseline and explain, in measurable terms, what the proposed technology improves. The program emphasizes meaningful performance advances, such as substantially better sensitivity and selectivity, improved spatial and temporal resolution (being able to see where a cell is and how it changes over time), improved scalability (handling many cells efficiently), and the ability to gather multiple global or functional readouts from single cells. Another key theme is non-destructive analysis, meaning approaches that can interrogate cells without destroying them, which can enable longitudinal tracking of the same cell or cell population over time.
A notable requirement is that proposals should include proof-of-concept testing in a complex biological tissue or a living organism, not just in simplified cell culture systems. This is meant to demonstrate that the technology can work under realistic biological conditions where cell types are mixed, signals can be weak, and the microenvironment influences cell behavior. The overall motivation is to enable a more fine-grained, integrative, and dynamic understanding of cellular heterogeneity, ultimately providing platforms that can transform research into the cellular basis of diseases by making it easier to identify rare cell states, transient functional changes, or spatially organized cellular subpopulations that are often missed by bulk methods.
Administratively, this is a discretionary grant opportunity offered by the National Institutes of Health using the SBIR mechanism, specifically the R43/R44 phases that correspond to SBIR Phase I (feasibility/proof of concept) and Phase II (development/expansion toward a product). Eligible applicants are small businesses, and the opportunity does not require cost sharing or matching funds. The FOA was posted March 13, 2013, with an original and final closing date of January 7, 2016, and it was archived February 7, 2016. The program is associated with a broad set of NIH and HHS-related research areas reflected in multiple CFDA numbers spanning human health and disease research domains, including genomics, cancer, mental health, neuroscience, aging, infectious diseases, cardiovascular research, and translational sciences, indicating that the tools developed under this announcement are intended to be broadly enabling across many biomedical fields.
For official details, the full announcement was hosted on the NIH grants site (PA-13-140), and NIH’s Office of Extramural Research webmaster contact was provided for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name and number of this NIH SBIR funding opportunity?
The opportunity is NIH SBIR Funding Opportunity Announcement (FOA) PA-13-140, titled "Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44)."
What is the main goal of PA-13-140?
The central goal is to support small businesses developing and validating next-generation tools and technologies for single-cell analysis, with an emphasis on reliably distinguishing different cellular states within heterogeneous tissues (instead of relying on averaged measurements from mixed cell populations).
What problem is this FOA trying to solve in biomedical research?
This FOA targets the limitations of bulk or mixed-population measurements that can mask rare, transient, or spatially organized cell states. It seeks technologies that can separate and characterize subtle cell-to-cell differences that are important for understanding development, normal physiology, and disease origins and progression.
Who is eligible to apply?
Eligible applicants are small businesses. The FOA uses the SBIR mechanism.
What SBIR grant phases/mechanisms does this FOA support?
This FOA uses the R43/R44 mechanisms, corresponding to SBIR Phase I (feasibility/proof of concept) and SBIR Phase II (development/expansion toward a product).
Is this FOA focused on basic research or technology development?
It is specifically framed around tool and technology development, with a clear path toward commercialization.
What does "commercialization path" mean in the context of this FOA?
The FOA emphasizes that applicants should position the project as a technology development effort that can progress toward a product. Proposals are expected to go beyond concept and describe improvements over the current state of the art in measurable performance terms.
What types of performance improvements does NIH emphasize?
Examples of meaningful performance advances highlighted in the FOA include substantially better sensitivity and selectivity, improved spatial and temporal resolution, improved scalability (efficient handling of many cells), and the ability to gather multiple global or functional readouts from single cells.
What does improved spatial and temporal resolution refer to?
Spatial resolution refers to being able to determine where a cell is (including within tissue context), and temporal resolution refers to tracking how a cell changes over time.
What does the FOA mean by scalability?
Scalability refers to the ability to handle many cells efficiently, which can be important for studying heterogeneous tissues where rare or transient cell states may only be detectable when large numbers of cells are analyzed.
What does "multiple global or functional readouts" mean here?
The FOA highlights interest in technologies that can capture more than one type of information from single cells, including broad (global) measurements or functional readouts, to support more integrative single-cell characterization.
Does the FOA encourage non-destructive single-cell analysis?
Yes. Non-destructive analysis is described as a key theme, meaning approaches that can interrogate cells without destroying them, enabling longitudinal tracking of the same cell or cell population over time.
Is proof-of-concept testing required, and where must it be demonstrated?
The FOA notes a requirement that proposals include proof-of-concept testing in a complex biological tissue or a living organism, not only in simplified cell culture systems.
Why does NIH require proof-of-concept in complex tissue or a living organism?
This is intended to show that the technology works under realistic biological conditions where cell types are mixed, signals can be weak, and the microenvironment influences cell behavior.
Are simplified cell culture-only demonstrations sufficient?
Based on the FOA description provided, proposals are expected to go beyond simplified cell culture-only testing by including proof-of-concept work in complex tissue or a living organism.
What is NIH expecting applicants to say about the "state of the art"?
Applicants are expected to treat the current state of the art as a baseline and explain what the proposed technology improves, using measurable terms.
What kinds of biological insights are these tools intended to enable?
The FOA is motivated by enabling a more fine-grained, integrative, and dynamic understanding of cellular heterogeneity, including identifying rare cell states, transient functional changes, and spatially organized cellular subpopulations that can be missed by bulk methods.
Is this opportunity limited to a specific disease area?
No. The FOA is associated with a broad set of NIH and HHS-related research areas and multiple CFDA numbers spanning many human health and disease research domains, indicating the tools are intended to be broadly enabling across biomedical fields.
What are examples of the broad research domains connected to this FOA?
The description references domains including genomics, cancer, mental health, neuroscience, aging, infectious diseases, cardiovascular research, and translational sciences, among others.
Does the program require cost sharing or matching funds?
No. The opportunity does not require cost sharing or matching funds.
Which federal agency is offering this opportunity?
The opportunity is offered by the National Institutes of Health (NIH) using the SBIR mechanism.
Is this a discretionary grant opportunity?
Yes. It is described as a discretionary grant opportunity.
When was this FOA posted, and when did it close?
The FOA was posted on March 13, 2013. The original and final closing date was January 7, 2016.
Is PA-13-140 still active?
No. The FOA was archived on February 7, 2016, indicating it is no longer an active open announcement.
Where can someone find the official announcement details?
The full announcement was hosted on the NIH grants site as PA-13-140.
Who was listed as the contact for access or linking issues?
NIH's Office of Extramural Research webmaster contact was provided for access or linking issues related to the official announcement.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 13 140) also looked into and applied for these:
| Funding Opportunity |
|---|
| Chronic Inflammation and Age related Disease (R01) Apply for PAR 13 233 Funding Number: PAR 13 233 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| NIH Small Research Grant Program (Parent R03) Apply for PA 13 304 Funding Number: PA 13 304 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $50,000 |
| NIH Exploratory/Developmental Research Grant Program (Parent R21) Apply for PA 13 303 Funding Number: PA 13 303 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Behavioral and Social Science Research on Understanding and Reducing Health Disparities (R21) Apply for PA 13 288 Funding Number: PA 13 288 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
| Modeling Social Behavior (R01) Apply for PAR 13 374 Funding Number: PAR 13 374 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Transformative Approaches for Cell Type Classification in the Brain (U01) Apply for RFA MH 14 215 Funding Number: RFA MH 14 215 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative New Technologies and Novel Approaches for Large Scale Recording and Modulation in the Nervous System (U01) Apply for RFA NS 14 007 Funding Number: RFA NS 14 007 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Planning for Next Generation Human Brain Imaging (R24) Apply for RFA MH 14 217 Funding Number: RFA MH 14 217 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $300,000 |
| BRAIN Initiative Optimization of Transformative Technologies for Large Scale Recording and Modulation in the Nervous System (U01) Apply for RFA NS 14 008 Funding Number: RFA NS 14 008 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Development and Validation of Novel Tools to Analyze Cell Specific and Circuit Specific Processes in the Brain (U01) Apply for RFA MH 14 216 Funding Number: RFA MH 14 216 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| BRAIN Initiative Integrated Approaches to Understanding Circuit Function in the Nervous System (U01) Apply for RFA NS 14 009 Funding Number: RFA NS 14 009 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Independent Scientist Award (Parent K02) Apply for PA 14 045 Funding Number: PA 14 045 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Bioengineering Research Partnerships (BRP) R01 Apply for PAR 14 092 Funding Number: PAR 14 092 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R43/R44) Apply for PA 14 154 Funding Number: PA 14 154 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R01) Apply for PA 14 155 Funding Number: PA 14 155 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $300,000 |
| Extended Development, Hardening and Dissemination of Technologies in Biomedical Computing, Informatics and Big Data Science (R01) Apply for PA 14 156 Funding Number: PA 14 156 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R41/R42) Apply for PA 14 157 Funding Number: PA 14 157 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Ethical, Legal, and Social Implications (ELSI) of Genomic Research Small Research Grant Program (R03) Apply for PA 14 277 Funding Number: PA 14 277 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $50,000 |
| Ethical, Legal, and Social Implications (ELSI) of Genomic Research Regular Research Program (R01) Apply for PA 14 276 Funding Number: PA 14 276 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: Case Dependent |
| Ethical, Legal, and Social Implications (ELSI) of Genomic Research Exploratory/Developmental Research Program (R21) Apply for PA 14 278 Funding Number: PA 14 278 Agency: National Institutes of Health Category: Education Environment Health Income Security and Social Services Funding Amount: $200,000 |
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