Opportunity Information: Apply for RFA AI 14 015
Apply for RFA AI 14 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of Novel Therapeutics for Select Anaerobic Protozoa (R21/R33)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jul 3, 2014 and posted on Jul 3, 2014.
- Applicants must submit their applications by Oct 30, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,100,000.00 to eligible and selected applicants.
- Eligible applicants include: City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses State governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Public housing authorities/Indian housing authorities Independent school districts County governments Small businesses Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity titled "Development of Novel Therapeutics for Select Anaerobic Protozoa (R21/R33)" (Funding Opportunity Number RFA-AI-14-015) is a discretionary NIH grant program designed to push forward early-stage translational research aimed at creating new treatments for certain anaerobic protozoal pathogens. In practical terms, the announcement is focused on moving ideas beyond basic discovery and into the first meaningful steps of therapy development, where investigators are starting to demonstrate that a candidate drug or therapeutic strategy could realistically be advanced toward a usable intervention.
This opportunity uses the NIH phased innovation-style grant mechanism R21/R33. The R21 phase is typically used to support exploratory, high-impact work that de-risks a concept and generates critical proof-of-concept data, while the R33 phase supports a more advanced set of milestone-driven activities that build directly on successful R21 outcomes. The overall structure signals that NIH is looking for projects that can start with early feasibility and then transition into more development-oriented work within the same overall program, rather than stopping at purely academic findings. The stated purpose makes clear that the emphasis is on novel therapeutics, meaning approaches that would expand or improve the current treatment landscape rather than simply re-running well-established strategies.
The activity category is Health, and the relevant CFDA program areas listed are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), aligning the program with NIH's infectious disease and microbiology research priorities. Cost sharing or matching is not required, which lowers administrative and financial barriers for applicants and is typical for NIH investigator-driven research grants.
From a funding and timing standpoint, the FOA was posted on July 3, 2014, with an original and current closing date of October 30, 2014, and it was later archived on November 30, 2014. The estimated total funding amount listed for the program is $3,100,000, indicating a modest but meaningful pool intended to support multiple projects, depending on the size and duration of awards and the number of meritorious applications received.
Eligibility is broad and intentionally inclusive, spanning a wide range of organization types. Eligible applicants include federal, state, county, city or township governments; special district governments; public housing authorities and Indian housing authorities; independent school districts; public and state controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); and for-profit organizations, including small businesses and for-profit entities other than small businesses. The FOA also explicitly includes a wide array of mission-driven and capacity-building institution types, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribal Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It further allows participation by non-domestic (non-U.S.) entities (foreign organizations), U.S. territories or possessions, regional organizations, faith-based or community-based organizations, and eligible agencies of the federal government. Overall, this eligibility language reflects NIH's interest in attracting a diverse set of applicants with the technical capability to contribute to therapeutic development, regardless of sector.
Administratively, the sponsoring agency is the National Institutes of Health. The full announcement was made available through the NIH Grants Guide, with an additional information link pointing to the official RFA page at http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-015.html. For access issues or technical problems with the posting, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which is a standard support contact for difficulties reaching or linking to the official FOA materials.
In summary, this FOA was structured to fund milestone-oriented, early translational projects that aim to deliver credible therapeutic candidates or approaches against select anaerobic protozoa, with a phased R21/R33 design to support both initial proof-of-concept work and subsequent development steps if early milestones are met. The program offered a dedicated funding pool, required no cost sharing, and welcomed applications from an unusually wide spectrum of domestic and international organizations across academia, government, nonprofit, and industry.
FAQs: Development of Novel Therapeutics for Select Anaerobic Protozoa (R21/R33) - RFA-AI-14-015
What is the title of this funding opportunity?
The funding opportunity is titled "Development of Novel Therapeutics for Select Anaerobic Protozoa (R21/R33)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-AI-14-015.
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What is the main purpose of this FOA?
The FOA is intended to advance early-stage translational research aimed at creating new treatments (novel therapeutics) for select anaerobic protozoal pathogens. The emphasis is on moving beyond basic discovery into the first meaningful steps of therapy development, including demonstrating that a candidate drug or therapeutic strategy could realistically be advanced toward a usable intervention.
What does "novel therapeutics" mean in the context of this announcement?
Within this FOA, "novel therapeutics" refers to approaches that expand or improve the current treatment landscape rather than repeating well-established strategies. The program is oriented toward new therapeutic candidates or new therapeutic strategies with credible development potential.
What type of NIH grant mechanism is used?
This opportunity uses the NIH phased innovation-style grant mechanism R21/R33.
How does the R21/R33 phased structure work?
The R21 phase typically supports exploratory, high-impact work designed to de-risk a concept and generate critical proof-of-concept data. The R33 phase supports a more advanced, milestone-driven set of activities that builds directly on successful R21 outcomes. The structure is designed so projects can transition from early feasibility to more development-oriented work within the same overall program.
Is this opportunity more focused on basic research or translational development?
Based on the stated purpose, the emphasis is on early translational research and initial therapy development steps, rather than purely academic or basic discovery work.
What is the activity category for this program?
The activity category is Health.
Which CFDA program areas are associated with this FOA?
The CFDA program areas listed are 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Is cost sharing or matching required?
No. Cost sharing or matching is not required for this opportunity.
What is the estimated total funding available for this program?
The estimated total funding amount listed is $3,100,000.
When was the FOA posted?
The FOA was posted on July 3, 2014.
What was the application closing date?
The original and current closing date listed is October 30, 2014.
Is this FOA still active?
No. The FOA was archived on November 30, 2014.
Who is eligible to apply?
Eligibility is broad and includes a wide range of domestic and international organization types. Eligible applicants include:
- Federal, state, county, city, or township governments
- Special district governments
- Public housing authorities and Indian housing authorities
- Independent school districts
- Public and state controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education)
- For-profit organizations, including small businesses and for-profit entities other than small businesses
- Eligible agencies of the federal government
- Faith-based and community-based organizations
- Regional organizations
- U.S. territories or possessions
- Non-domestic (non-U.S.) entities (foreign organizations)
Are small businesses and other for-profit entities allowed to apply?
Yes. The FOA explicitly includes for-profit organizations, including small businesses, as eligible applicants.
Are nonprofits required to have 501(c)(3) status to be eligible?
No. The FOA includes nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education).
Are international (non-U.S.) organizations eligible to apply?
Yes. The FOA allows participation by non-domestic (non-U.S.) entities (foreign organizations).
Does the FOA encourage or include specific institution types such as HBCUs or Tribal Colleges?
Yes. The eligibility language explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribal Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Where can applicants view the official announcement?
The full announcement was made available through the NIH Grants Guide. An official RFA page is provided at: http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-14-015.html.
Who should be contacted for technical issues accessing the FOA posting?
For access issues or technical problems with the posting, the contact provided is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall theme of the projects NIH wanted to fund under this FOA?
The FOA was structured to fund milestone-oriented, early translational projects intended to deliver credible therapeutic candidates or approaches against select anaerobic protozoa, using a phased R21/R33 design to support proof-of-concept work followed by development steps if early milestones are achieved.
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